Search Results - "Kim, Rokhyun"
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Multidimensional fragmentomic profiling of cell-free DNA released from patient-derived organoids
Published in Human genomics (28-10-2023)“…BackgroundFragmentomics, the investigation of fragmentation patterns of cell-free DNA (cfDNA), has emerged as a promising strategy for the early detection of…”
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A single-cell atlas of in vitro multiculture systems uncovers the in vivo lineage trajectory and cell state in the human lung
Published in Experimental & molecular medicine (01-08-2023)“…We present an in-depth single-cell atlas of in vitro multiculture systems on human primary airway epithelium derived from normal and diseased lungs of 27…”
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Abstract A034: Single cell RNA sequencing of triple negative breast cancer patient-derived xenograft model identifies CRABP1 of cancer-associated fibroblast as a key regulator of breast cancer metastasis
Published in Cancer research (Chicago, Ill.) (17-11-2024)“…Triple-negative breast cancer (TNBC) is associated with a high risk of distant metastasis, particularly to the lung and liver. Both intrinsic characteristics…”
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Abstract 4254: Genetically engineered human lung organoid models for lung cancer evolution study
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Initial cellular events in a transitional period from normal to cancer cells, such as transcriptomic or epigenetic dynamics, are poorly understood. Observing…”
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Assembly of glioblastoma tumoroids and cerebral organoids: a 3D in vitro model for tumor cell invasion
Published in Molecular oncology (30-10-2024)“…Glioblastoma (GBM) has a fatal prognosis because of its aggressive and invasive characteristics. Understanding the mechanism of invasion necessitates an…”
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Case Series of Soft Tissue Sarcoma Patients with Brain Metastasis with Implications from Genomic and Transcriptomic Analysis
Published in Cancer research and treatment (01-04-2024)“…Brain metastasis rarely occurs in soft tissue sarcoma (STS). Here, we present five cases of STS with brain metastases with genetic profiles. We included five…”
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