Search Results - "Kim, Meong Il"
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Crystal structure of Bacillus cereus flagellin and structure-guided fusion-protein designs
Published in Scientific reports (11-04-2018)“…Flagellin is a major component of the flagellar filament. Flagellin also functions as a specific ligand that stimulates innate immunity through direct…”
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Monoclonal antibody Y01 prevents tauopathy progression induced by lysine 280-acetylated tau in cell and mouse models
Published in The Journal of clinical investigation (17-04-2023)“…The spatiotemporal pattern of the spread of pathologically modified tau through brain regions in Alzheimer's disease (AD) can be explained by prion-like…”
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Crystal structure of the Bacillus-conserved MazG protein, a nucleotide pyrophosphohydrolase
Published in Biochemical and biophysical research communications (25-03-2016)“…BA1544 from Bacillus anthracis was previously annotated as a transcription factor for the gene cluster ba1554 - ba1558, but has not been experimentally…”
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Structure-based molecular characterization and regulatory mechanism of the LftR transcription factor from Listeria monocytogenes: Conformational flexibilities and a ligand-induced regulatory mechanism
Published in PloS one (10-04-2019)“…Listeria monocytogenes is a foodborne pathogen that causes listeriosis and can lead to serious clinical problems, such as sepsis and meningitis, in…”
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Crystal structure of the flagellar chaperone FliS from Bacillus cereus and an invariant proline critical for FliS dimerization and flagellin recognition
Published in Biochemical and biophysical research communications (27-05-2017)“…FliS is a cytoplasmic flagellar chaperone for the flagellin, which polymerizes into filaments outside of the flagellated bacteria. Cytoplasmic interaction…”
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Crystal structure and catalytic mechanism of pyridoxal kinase from Pseudomonas aeruginosa
Published in Biochemical and biophysical research communications (09-09-2016)“…Pyridoxal kinase is a ubiquitous enzyme essential for pyridoxal 5′-phosphate (PLP) homeostasis since PLP is required for the catalytic activity of a variety of…”
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Structural and functional analysis of BF2549, a PadR-like transcription factor from Bacteroides fragilis
Published in Biochemical and biophysical research communications (29-01-2017)“…A phenolic acid decarboxylase (padC) regulator, PadR and its homologs proteins belong to the PadR family. Despite the growing numbers of the PadR family…”
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Structure-based functional analysis of a PadR transcription factor from Streptococcus pneumoniae and characteristic features in the PadR subfamily-2
Published in Biochemical and biophysical research communications (05-11-2020)“…Since the first discovery of phenolic acid decarboxylase transcriptional regulator (PadR), its homologs have been identified mostly in bacterial species and…”
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Structural and functional analysis of a PadR-like transcription factor from Bacteroides fragilis
Published in Acta crystallographica. Section A, Foundations and advances (20-07-2018)“…Abstract only…”
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Crystal structure of the Pseudomonas aeruginosa PA0423 protein and its functional implication in antibiotic sequestration
Published in Biochemical and biophysical research communications (12-07-2020)“…Pseudomonas aeruginosa is a widely found opportunistic pathogen. The emergence of multidrug-resistant strains and persistent chronic infections have increased…”
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Structure analysis of Bacillus cereus MepR-like transcription regulator, BC0657, in complex with pseudo-ligand molecules
Published in Biochemical and biophysical research communications (13-03-2015)“…The MarR family of transcriptional regulatory proteins in bacteria and archaea respond to environmental changes and regulate transcriptional processes by…”
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Recombinant Protein Expression, Crystallization, and Biophysical Studies of a Bacillus-conserved Nucleotide Pyrophosphorylase, BcMazG
Published in Journal of visualized experiments (16-05-2017)“…To overcome safety restrictions and regulations when studying genes and proteins from true pathogens, their homologues can be studied. Bacillus anthracis is an…”
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Expression and regulation of inhibitor of DNA binding proteins ID1, ID2, ID3, and ID4 at the maternal-conceptus interface in pigs
Published in Theriogenology (01-03-2018)“…Inhibitor of DNA binding (ID) proteins, ID1, ID2, ID3, and ID4 are transcriptional regulators that have a helix-loop-helix (HLH) domain but not a basic DNA…”
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Structure-guided fusion-protein designs using Bacillus flagellin as a vaccine adjuvant
Published in Acta crystallographica. Section A, Foundations and advances (20-07-2018)“…Abstract only…”
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Massively Parallel Screening of Toll/Interleukin-1 Receptor (TIR)-Derived Peptides Reveals Multiple Toll-Like Receptors (TLRs)-Targeting Immunomodulatory Peptides
Published in Advanced science (31-10-2024)“…Toll-like receptors (TLRs) are critical regulators of the immune system, and altered TLR responses lead to a variety of inflammatory diseases. Interference of…”
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Purification, crystallization and X-ray crystallographic studies of a Bacillus cereus MepR-like transcription factor, BC0657
Published in Acta crystallographica. Section F, Structural biology communications (01-06-2015)“…Transcription factors of the MarR family respond to internal and external changes and regulate a variety of biological functions through ligand association…”
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