Search Results - "Kim, Key H"

Synthesis and Antitumor Activity of a Series of [2-Substituted-4,5-bis(aminomethyl)-1,3-Dioxolane]platinum(II) Complexes by Kim, Dae-Kee, Kim, Ganghyeok, Gam, Jongsik, Cho, Yong-Baik, Kim, Hun-Taek, Tai, Joo-Ho, Kim, Key H, Hong, Weon-Seon, Park, Jae-Gahb

“…The synthesis, physical properties, antitumor activity, structure-activity relationships, and nephrotoxicity of a series of…”
Get full text

Synthesis and Anti-HIV-1 Activity of a Series of 1-Alkoxy-5-alkyl-6-(arylthio)uracils by Kim, Dae-Kee, Gam, Jongsik, Kim, Young-Woo, Lim, Jinsoo, Kim, Hun-Taek, Kim, Key H

“…A series of 1-alkoxy-5-alkyl-6-(arylthio)uracils was synthesized and tested for their ability to inhibit HIV-1 replication. Treatment of…”
Get full text

Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study by Jung, Y B, Roh, K J, Jung, J A, Jung, K, Yoo, H, Cho, Y B, Kwak, W J, Kim, D K, Kim, K H, Han, C K

“…SKI 306X is a purified extract from a mixture of three oriental herbal medicines (Clematis mandshurica, Trichosanthes kirilowii and Prunella vulgaris) that…”
Get more information

A Phase I study of cis‐malonato[(4R,5R)‐4,5‐bis(aminomethyl)‐1,3‐dioxolane] platinum(II) in patients with advanced malignancies by Kim, Noe Kyeong, Kim, Tae‐You, Shin, Sang‐Goo, Park, Young Iee, Lee, Jung Ae, Cho, Yong‐Baik, Kim, Key H., Kim, Dae‐Kee, Heo, Dae Seog, Bang, Yung‐Jue

“…BACKGROUND A Phase I study of cis‐malonato[(4R,5R)‐4,5‐bis(aminomethyl)‐1,3‐dioxolane] platinum(II) (SKI 2053R), a new platinum derivative, was performed to…”
Get full text

Synthesis and evaluation of amino acid esters of 6-deoxypenciclovir as potential prodrugs of penciclovir by Kim, D K, Lee, N, Kim, Y W, Chang, K, Im, G J, Choi, W S, Kim, K H

“…The amino acid ester derivatives of 6-deoxypenciclovir, 11-20, were synthesized as potential prodrugs of penciclovir, and were evaluated for their oral…”
Get full text

Synthesis and evaluation of 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine mono- and diesters as potential prodrugs of penciclovir by Kim, D K, Lee, N, Kim, H T, Im, G J, Kim, K H

“…2-Amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine (7), and its mono- and diesters 8-15 were prepared and evaluated for their potential as prodrugs…”
Get full text

Synthesis and Evaluation of 2-Amino-9-(3-hydroxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as Potential Prodrugs of Penciclovir by Kim, Dae-Kee, Lee, Namkyu, Kim, Young-Woo, Chang, Kieyoung, Kim, Jae-Sun, Im, Guang-Jin, Choi, Won-Son, Jung, Inho, Kim, Taek-Soo, Hwang, Yong-Youn, Min, Dong-Sun, Um, Key An, Cho, Yong-Baik, Kim, Key H

“…A series of 2-amino-9-(3-hydroxymethyl-4-alkoxycarbonyloxybut-1-yl)purines (4−10) and 2-amino-9-(2-(2-oxo-1,3-dioxan-5-yl)ethyl)purine (1) were synthesized as…”
Get full text

Synthesis and evaluation of 2-amino-6-fluoro-9-(2-hydroxyethoxymethyl)purine esters as potential prodrugs of acyclovir by Kim, Dae-Kee, Lee, Namkyu, Im, Guang-Jin, Kim, Hun-Taek, Kim, Key H.

“…2-Amino-6-fluoro-9-(2-hydroxyethoxymethyl)purine ( 2) and its ester derivatives 4a–d were synthesized as potential prodrugs of acyclovir, and were evaluated…”
Get full text

Synthesis and Evaluation of 2-Amino-9-(1,3-dihydroxy-2-propoxymethyl)- 6-fluoropurine Mono- and Diesters as Potential Prodrugs of Ganciclovir by Kim, Dae-Kee, Chang, Kieyoung, Im, Guang-Jin, Kim, Hun-Taek, Lee, Namkyu, Kim, Key H

“…A series of 2-amino-9-(1,3-dihydroxy-2-propoxymethyl)-6-fluoropurine mono- and diesters, 6a−h, were synthesized as potential prodrugs of ganciclovir and…”
Get full text

A convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils by Kim, Dae-Kee, Kim, Young-Woo, Gam, Jongsik, Lim, Jinsoo, Kim, Key H

“…Graphic A general and convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils via 1,5-dialkyl-6-(methylsulfonyl)uracils 1…”
Get full text

Synthesis and evaluation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as potential prodrugs of penciclovir by KIM, D.-K, LEE, N, COLLEDGE, D, LOCARNINI, S, DO HYUN RYU, KIM, Y.-W, KIM, J.-S, CHANG, K, IM, G.-J, CHOI, W.-S, CHO, Y.-B, KIM, K. H

“…A series of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purin es (1-8) and 2-amino-9-(3-alkoxycarbonyl-oxymethyl-4-alkoxycarbonyloxybut…”
Get full text

Antitumor activity of five new platinum complexes having a glycolate leaving ligand by Hong, W S, Min, Y I, Kim, H T, Cho, Y B, Kim, K H, Kim, D K

“…In an attempt to develop a new anticancer platinum complex with greater or equivalent antitumor activity but reduced side effects compared with cisplatin…”
Get full text

A Phase I study ofcis-malonato[(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane] platinum(II) in patients with advanced malignancies by Kim, Noe Kyeong, Kim, Tae-You, Shin, Sang-Goo, Park, Young Iee, Lee, Jung Ae, Cho, Yong-Baik, Kim, Key H., Kim, Dae-Kee, Heo, Dae Seog, Bang, Yung-Jue

Get full text

Synthesis and in vitro cytotoxicity of cis-dichloro[(2 S,3 R,4 S)-2-aminomethyl-3,4-( O-isopropylidene)dihydroxy- or -3,4-dihydroxypyrrolidine]platinum(II) by Kim, Dae-Kee, Kim, Young-Woo, Kim, Hun-Taek, Kim, Key H.

“…cis-Dichloro[(2 S,3 R,4 S)-2-aminomethyl-3,4-( O-isopropylidene)dihydroxypyrrolidine]platinum(II) ( 1) and cis-dichloro[(2 S,3 R,4…”
Get full text

Enantioselective synthesis of (R)- and (S)-2-alkyl-1,4-butanediolsvia enantiomerically pure 3-alkyl-5-(menthyloxy)butyrolactones by Lee, Namkyu, Kim, Young-Woo, Chang, Kieyoung, Kim, Key H., Jew, Sang-Sup, Kim, Dae-Kee

Get full text

Antitumor activity of cis-malonato[(4R,5R)-4,5-bis(aminomethy1)-2-isopropyl-1,3-dioxolanelplatinum(II), a new platinum analogue, as an anticancer agent by Kim, Dae-Kee, Kim, Hun-Taek, Cho, Yong-Baik, Tai, Joo Ho, Ahn, Jae Suk, Kim, Taek-Soo, Kim, Key H., Hong, Weon-Seon

Get full text

Enantioselective synthesis of ( R)- and ( S)-2-alkyl-1,4-butanediols via enantiomerically pure 3-alkyl-5-(menthyloxy)butyrolactones by Lee, Namkyu, Kim, Young-Woo, Chang, Kieyoung, Kim, Key H., Jew, Sang-Sup, Kim, Dae-Kee

“…A general and practical symthesis of optically pure ( R)- and (S)-2-ethyl, 2-propyl and 2-isopropyl-1,4-butanediols, 9a-c, has been accomplished from optically…”
Get full text

Influence of exposure and infusion times on the cytotoxicity and pharmacokinetics of cis - malonato[(4 R , 5 R )-4,5-bis(aminomethyl)- 2-isopropyl-1,3-dioxolane]platinum(II) by Kim, Hun-Taek, Kim, D.-K., Cho, Yong-Baik, Kim, Taek-Soo, Jung, I., Kim, Key H., Heo, Dae Seog, Bang, Yung-Jue, Shin, Sang-Goo, Kim, Noe Kyeong

Get full text

Synthesis and in vitro cytotoxicity of cis-(glycolato- O, O′)-[2-substituted-(4 R,5 R)-4,5-bis(aminomethyl)-1,3-dioxolane]platinum (II) by Kim, Dae-Kee, Gam, Jongsik, Kim, Hun-Taek, Kim, Key H.

“…The synthesis and in vitro cytotoxicity of cis-(glycolato- O, O′)[2-substituted-(4 R,5 R)-4,5-bis(aminomethyl)-1,3-dioxolane]platinum(II) are described. Among…”
Get full text

Pharmacokinetics and antitumor activity of a new platinum compound, cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II), as determined by ex vivo pharmacodynamics by DAE-KEE KIM, HUN-TAEK KIM, JOO HO TAI, YONG-BAIK CHO, TAEK-SOO KIM, KIM, K. H, JAE-GAHB PARK, WEON-SEON HONG

“…The pharmacokinetics and ex vivo pharmacodynamics studies on cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1, 3- dioxolane]platinum(II) (SKI 2053R, NSC…”
Get full text