Search Results - "Kim, Jong‐Youl"

Mechanisms and Potential Therapeutic Applications of Microglial Activation after Brain Injury by Kim, Jong‐Youl, Kim, Nuri, Yenari, Midori A.

“…Summary As the resident immune cells of the central nervous system, microglia rapidly respond to brain insults, including stroke and traumatic brain injury…”
Get full text

NOX inhibitors as a therapeutic strategy for stroke and neurodegenerative disease by Cairns, Belinda, Kim, Jong Youl, Tang, Xian Nan, Yenari, Midori A

“…NADPH oxidase was originally identified in immune cells as playing an important microbicidal role. In neurodegenerative and cerebrovascular diseases,…”
Get more information

Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke by Kawabori, Masahito, Kacimi, Rachid, Kauppinen, Tiina, Calosing, Cyrus, Kim, Jong Youl, Hsieh, Christine L, Nakamura, Mary C, Yenari, Midori A

“…Clearing cellular debris after brain injury represents an important mechanism in regaining tissue homeostasis and promoting functional recovery. Triggering…”
Get full text

The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke by Kim, Jong Youl, Han, Yeonseung, Lee, Jong Eun, Yenari, Midori A

“…The 70-kDa heat shock protein (Hsp70) is a cytosolic chaperone which facilitates protein folding, degradation, complex assembly, and translocation. Following…”
Get more information

Adiponectin: The Potential Regulator and Therapeutic Target of Obesity and Alzheimer's Disease by Kim, Jong Youl, Barua, Sumit, Jeong, Ye Jun, Lee, Jong Eun

“…Animal and human mechanistic studies have consistently shown an association between obesity and Alzheimer's disease (AD). AD, a degenerative brain disease, is…”
Get full text

Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors by Barua, Sumit, Kim, Jong Youl, Kim, Jae Young, Kim, Jae Hwan, Lee, Jong Eun

“…The central nervous system (CNS) is the most injury-prone part of the mammalian body. Any acute or chronic, central or peripheral neurological disorder is…”
Get full text

Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells by Kim, Jong Youl, Park, Joohyun, Chang, Ji Young, Kim, Sa-Hyun, Lee, Jong Eun

“…The immune response after stroke is known to play a major role in ischemic brain pathobiology. The inflammatory signals released by immune mediators activated…”
Get full text

Role of DPP-4 and SGLT2 Inhibitors Connected to Alzheimer Disease in Type 2 Diabetes Mellitus by Sim, A Young, Barua, Sumit, Kim, Jong Youl, Lee, Yong-ho, Lee, Jong Eun

“…Alzheimer’s disease (AD) is characterized by memory loss and cognitive decline. Additionally, abnormal extracellular amyloid plaques accumulation and nerve…”
Get full text

Therapeutic Hypothermia and Neuroprotection in Acute Neurological Disease by Kurisu, Kota, Kim, Jong Youl, You, Jesung, Yenari, Midori A

“…Therapeutic hypothermia has consistently been shown to be a robust neuroprotectant in many labs studying different models of neurological disease. Although…”
Get more information

Ischemic stroke outcome after promoting CD4+CD25+ Treg cell migration through CCR4 overexpression in a tMCAO animal model by Lee, Seowoo, Kim, Jiwon, You, Je Sung, Hyun, Young-Min, Kim, Jong Youl, Lee, Jong Eun

“…The importance of neuroinflammation during the ischemic stroke has been extensively studied. The role of CD4+CD25+ regulatory T (Treg) cells during the…”
Get full text

Maintenance of the Neuroprotective Function of the Amino Group Blocked Fluorescence-Agmatine by Barua, Sumit, Sim, A Young, Kim, Jong Youl, Shin, Injae, Lee, Jong Eun

“…Agmatine, an endogenous derivative of arginine, has been found to be effective in treating idiopathic pain, convulsion, stress-mediated behavior, and attenuate…”
Get full text

Therapeutic hypothermia for stroke: Unique challenges at the bedside by You, Je Sung, Kim, Jong Youl, Yenari, Midori A.

“…Therapeutic hypothermia has shown promise as a means to improving neurological outcomes at several neurological conditions. At the clinical level, it has been…”
Get full text

ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex by Park, Kyungho, Ikushiro, Hiroko, Seo, Ho Seong, Shin, Kyong-Oh, Kim, Young il, Kim, Jong Youl, Lee, Yong-Moon, Yano, Takato, Holleran, Walter M., Elias, Peter, Uchida, Yoshikazu

“…We recently identified a previously unidentified sphingosine-1-phosphate (S1P) signaling mechanism that stimulates production of a key innate immune element,…”
Get full text

CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation by Kim, Jong Youl, Kim, Jiwon, Huang, Meiying, Kosonen, Renée, Lee, Jong Eun

“…Microglia, resident macrophages in the brain, play major roles in neuroinflammation after an acute many neurological diseases, including stroke. Our recent…”
Get full text

Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke? by Park, Joohyun, Chang, Ji Young, Kim, Jong Youl, Lee, Jong Eun

“…The immune response following neuroinflammation is a vital element of ischemic stroke pathophysiology. After the onset of ischemic stroke, a specialized…”
Get full text

Heat Shock Protein 70 (HSP70) Induction: Chaperonotherapy for Neuroprotection after Brain Injury by Kim, Jong Youl, Barua, Sumit, Huang, Mei Ying, Park, Joohyun, Yenari, Midori A, Lee, Jong Eun

“…The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to protect the brain from various nervous system injuries. It allows…”
Get full text

SGLT2 and DPP4 inhibitors improve Alzheimer’s disease–like pathology and cognitive function through distinct mechanisms in a T2D–AD mouse model by Sim, A Young, Choi, Da Hyun, Kim, Jong Youl, Kim, Eun Ran, Goh, A-ra, Lee, Yong-ho, Lee, Jong Eun

“…Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2D) share common features, including insulin resistance. Brain insulin resistance has been implicated…”
Get full text

Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke by Zheng, Zhen, Kim, Jong Youl, Ma, Hualong, Lee, Jong Eun, Yenari, Midori A

“…The 70-kDa heat shock protein (Hsp70) is involved in protecting the brain from a variety of insults including stroke. Although the mechanism has been largely…”
Get full text

The 70 kDa heat shock protein protects against experimental traumatic brain injury by Kim, Jong Youl, Kim, Nuri, Zheng, Zhen, Lee, Jong Eun, Yenari, Midori A

“…Abstract Traumatic brain injury (TBI) causes disruption of the blood brain barrier (BBB) leading to hemorrhage which can complicate an already catastrophic…”
Get full text

Role of agmatine in the application of neural progenitor cell in central nervous system diseases: therapeutic potentials and effects by Kosonen, Renée, Barua, Sumit, Kim, Jong Youl, Lee, Jong Eun

“…Agmatine, the primary decarboxylation product of L-arginine, generated from arginine decarboxylase. Since the discovery of agmatine in the mammalian brain in…”
Get full text