Search Results - "Kim, Jocelyn T"

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy by Sigal, Alex, Kim, Jocelyn T., Balazs, Alejandro B., Dekel, Erez, Mayo, Avi, Milo, Ron, Baltimore, David

“…HIV persists through continued transmission Antiretroviral therapy suppresses, but does not eradicate, HIV infection. Low-level viraemia continues for life…”
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A humanized mouse model to study NK cell biology during HIV infection by Kim, Jocelyn T, Zack, Jerome A

“…NK cells are an important subset of innate immune effectors with antiviral activity. However, NK cell development and immune responses in different tissues…”
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Latency reversal plus natural killer cells diminish HIV reservoir in vivo by Kim, Jocelyn T., Zhang, Tian-Hao, Carmona, Camille, Lee, Bryanna, Seet, Christopher S., Kostelny, Matthew, Shah, Nisarg, Chen, Hongying, Farrell, Kylie, Soliman, Mohamed S. A., Dimapasoc, Melanie, Sinani, Michelle, Blanco, Kenia Yazmin Reyna, Bojorquez, David, Jiang, Hong, Shi, Yuan, Du, Yushen, Komarova, Natalia L., Wodarz, Dominik, Wender, Paul A., Marsden, Matthew D., Sun, Ren, Zack, Jerome A.

“…HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected cells. Previous studies have shown that natural killer…”
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Dendritic cells efficiently transmit HIV to T Cells in a tenofovir and raltegravir insensitive manner by Kim, Jocelyn T, Chang, Emery, Sigal, Alex, Baltimore, David

“…Dendritic cell (DC)-to-T cell transmission is an example of infection in trans, in which the cell transmitting the virus is itself uninfected. During this mode…”
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Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention by Li, Yan-Ruide, Dunn, Zachary Spencer, Garcia, Jr, Gustavo, Carmona, Camille, Zhou, Yang, Lee, Derek, Yu, Jiaji, Huang, Jie, Kim, Jocelyn T, Arumugaswami, Vaithilingaraja, Wang, Pin, Yang, Lili

“…New COVID-19 treatments are desperately needed as case numbers continue to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized…”
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Current Advances in Humanized Mouse Models for Studying NK Cells and HIV Infection by Kim, Jocelyn T, Bresson-Tan, Gabrielle, Zack, Jerome A

“…Human immunodeficiency virus (HIV) has infected millions of people worldwide and continues to be a major global health problem. Scientists required a small…”
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Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo by Pache, Lars, Marsden, Matthew D., Teriete, Peter, Portillo, Alex J., Heimann, Dominik, Kim, Jocelyn T., Soliman, Mohamed S.A., Dimapasoc, Melanie, Carmona, Camille, Celeridad, Maria, Spivak, Adam M., Planelles, Vicente, Cosford, Nicholas D.P., Zack, Jerome A., Chanda, Sumit K.

“…“Shock and kill” strategies focus on purging the latent HIV-1 reservoir by treating infected individuals with therapeutics that activate the latent virus and…”
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A cocktail of thermally stable, chemically synthesized capture agents for the efficient detection of anti-gp41 antibodies from human sera by Pfeilsticker, Jessica A, Umeda, Aiko, Farrow, Blake, Hsueh, Connie L, Deyle, Kaycie M, Kim, Jocelyn T, Lai, Bert T, Heath, James R

“…We report on a method to improve in vitro diagnostic assays that detect immune response, with specific application to HIV-1. The inherent polyclonal diversity…”
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T cell antigen discovery via trogocytosis by Li, Guideng, Bethune, Michael T., Wong, Stephanie, Joglekar, Alok V., Leonard, Michael T., Wang, Jessica K., Kim, Jocelyn T., Cheng, Donghui, Peng, Songming, Zaretsky, Jesse M., Su, Yapeng, Luo, Yicheng, Heath, James R., Ribas, Antoni, Witte, Owen N., Baltimore, David

“…T cell receptor (TCR) ligand discovery is essential for understanding and manipulating immune responses to tumors. We developed a cell-based selection platform…”
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Secreted factors induced by PKC modulators do not indirectly cause HIV latency reversal by Moran, Jose A., Ranjan, Alok, Hourani, Rami, Kim, Jocelyn T., Wender, Paul A., Zack, Jerome A., Marsden, Matthew D.

“…HIV can establish a long-lived latent infection in cells harboring integrated non-expressing proviruses. Latency reversing agents (LRAs), including protein…”
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Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping by Sung, Kevin, Ding, Yichen, Ma, Jianguo, Chen, Harrison, Huang, Vincent, Cheng, Michelle, Yang, Cindy F., Kim, Jocelyn T., Eguchi, Daniel, Di Carlo, Dino, Hsiai, Tzung K., Nakano, Atsushi, Kulkarni, Rajan P.

“…Tissue clearing methods promise to provide exquisite three-dimensional imaging information; however, there is a need for simplified methods for lower resource…”
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HLA-A∗02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses by Nesterenko, Pavlo A., McLaughlin, Jami, Tsai, Brandon L., Burton Sojo, Giselle, Cheng, Donghui, Zhao, Daniel, Mao, Zhiyuan, Bangayan, Nathanael J., Obusan, Matthew B., Su, Yapeng, Ng, Rachel H., Chour, William, Xie, Jingyi, Li, Yan-Ruide, Lee, Derek, Noguchi, Miyako, Carmona, Camille, Phillips, John W., Kim, Jocelyn T., Yang, Lili, Heath, James R., Boutros, Paul C., Witte, Owen N.

“…Cross-reactivity and direct killing of target cells remain underexplored for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific CD8+…”
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Tracking HIV Rebound following Latency Reversal Using Barcoded HIV by Marsden, Matthew D., Zhang, Tian-hao, Du, Yushen, Dimapasoc, Melanie, Soliman, Mohamed S.A., Wu, Xiaomeng, Kim, Jocelyn T., Shimizu, Akira, Schrier, Adam, Wender, Paul A., Sun, Ren, Zack, Jerome A.

“…HIV latency prevents cure of infection with antiretroviral therapy (ART) alone. One strategy for eliminating latently infected cells involves the induction of…”
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Defining the Effects of PKC Modulator HIV Latency-Reversing Agents on Natural Killer Cells by Dimapasoc, Melanie, Moran, Jose A, Cole, Steve W, Ranjan, Alok, Hourani, Rami, Kim, Jocelyn T, Wender, Paul A, Marsden, Matthew D, Zack, Jerome A

“…Latency reversing agents (LRAs) such as protein kinase C (PKC) modulators can reduce rebound-competent HIV reservoirs in small animal models. Furthermore,…”
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Occult Colonic Perforation in a Patient With Coronavirus Disease 2019 After Interleukin-6 Receptor Antagonist Therapy by Schwab, Kristin, Hamidi, Sepehr, Chung, Augustine, Lim, Raymond J, Khanlou, Negar, Hoesterey, Daniel, Dumitras, Camelia, Adeyiga, Oladunni B, Phan-Tang, Michelle, Wang, Tisha S, Saggar, Rajan, Goldstein, Jeffrey, Belperio, John A, Dubinett, Steven M, Kim, Jocelyn T, Salehi-Rad, Ramin

“…Abstract Background Interleukin-6 blockade (IL-6) has become a focus of therapeutic investigation for the coronavirus disease 2019 (COVID-19). Methods We…”
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