Search Results - "Kim, Iana V"
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A precisely positioned MED12 activation helix stimulates CDK8 kinase activity
Published in Proceedings of the National Academy of Sciences - PNAS (11-02-2020)“…The Mediator kinase module regulates eukaryotic transcription by phosphorylating transcription-related targets and by modulating the association ofMediator and…”
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Planarians recruit piRNAs for mRNA turnover in adult stem cells
Published in Genes & development (01-11-2019)“…PIWI proteins utilize small RNAs called piRNAs to silence transposable elements, thereby protecting germline integrity. In planarian flatworms, PIWI proteins…”
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Efficient depletion of ribosomal RNA for RNA sequencing in planarians
Published in BMC genomics (29-11-2019)“…The astounding regenerative abilities of planarian flatworms prompt steadily growing interest in examining their molecular foundation. Planarian regeneration…”
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Genome-Wide Analysis of Planarian piRNAs
Published in Methods in molecular biology (Clifton, N.J.) (2023)“…In planarian flatworms, the piRNA pathway is operated by three PIWI proteins, termed SMEDWI-1, SMEDWI-2, and SMEDWI-3 (SMEDWI = Schmidtea mediterranea PIWI)…”
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Isolation and Library Preparation of Planarian piRNAs
Published in Methods in molecular biology (Clifton, N.J.) (2023)“…In planarian flatworms, piRNAs and SMEDWI (Schmidtea mediterranea PIWI) proteins are both essential for the animals' impressive regenerative ability and for…”
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DNA methylation enables recurrent endogenization of giant viruses in an animal relative
Published in Science advances (12-07-2024)“…5-Methylcytosine (5mC) is a widespread silencing mechanism that controls genomic parasites. In eukaryotes, 5mC has gained complex roles in gene regulation…”
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