Search Results - "Kim, Francis"
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Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis–like disease and inflammation
Published in Nature immunology (01-04-2020)“…A20 is an anti-inflammatory protein that is strongly linked to human disease. Here, we find that mice expressing three distinct targeted mutations of A20’s…”
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Readability of 10‐K Reports and Stock Price Crash Risk
Published in Contemporary accounting research (01-06-2019)“…ABSTRACT This study shows that less readable 10‐K reports are associated with higher stock price crash risk. The results are consistent with the argument that…”
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Coronary endothelial dysfunction: from pathogenesis to clinical implications
Published in Open heart (01-12-2022)“…Endothelial dysfunction (ED) has a substantial role in the pathogenesis of atherosclerosis and other vascular diseases. Multiple risk factors, including…”
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Policy Uncertainty and the Dual Role of Corporate Political Strategies
Published in Financial management (22-06-2019)“…Firms use active political strategies not only to mitigate uncertainty emanating from legislative activity, but also to enhance their growth opportunities. We…”
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Saturated Fatty Acids and Inflammation: Who Pays the Toll?
Published in Arteriosclerosis, thrombosis, and vascular biology (01-04-2010)Get full text
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Type 2 diabetes is associated with loss of HDL endothelium protective functions
Published in PloS one (15-03-2018)“…One of the hallmarks of diabetes is impaired endothelial function. Previous studies showed that HDL can exert protective effects on endothelium stimulating NO…”
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Linking land displacement and environmental dispossession to Mi'kmaw health and well‐being: Culturally relevant place‐based interpretive frameworks matter
Published in The Canadian geographer (01-03-2021)“…For over five decades, Pictou Landing First Nation, a small Mi'kmaw community on the northern shore of Nova Scotia, has been told that the health of its…”
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The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells
Published in Cell stem cell (10-04-2008)“…EGR1 is a member of the immediate early response transcription factor family and functions in cell growth, development, and stress responses in many tissues…”
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Experience Using Ustekinumab in Pediatric Patients With Medically Refractory Crohn Disease
Published in Journal of pediatric gastroenterology and nutrition (01-11-2021)“…ABSTRACT Introduction: Ustekinumab (UST), a human monoclonal antibody against interleukin‐12 and 23, is approved to treat adult patients with psoriasis or…”
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The Immunological Genome Project: networks of gene expression in immune cells
Published in Nature immunology (01-10-2008)“…The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression…”
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Bystander Interventions Can Improve Outcomes From Out-of-Hospital Cardiac Arrest
Published in JAMA : the journal of the American Medical Association (21-07-2015)“…Until recently, most communities reported that outcomes after out-of-hospital cardiac arrest had not improved for more than 30 years. This contrasts markedly…”
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Systemic signals regulate ageing and rejuvenation of blood stem cell niches
Published in Nature (London) (28-01-2010)“…Ageing in multicellular organisms typically involves a progressive decline in cell replacement and repair processes, resulting in several physiological…”
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Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity
Published in Circulation research (08-06-2007)“…Vascular dysfunction is a major complication of metabolic disorders such as diabetes and obesity. The current studies were undertaken to determine whether…”
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M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling
Published in Diabetes (New York, N.Y.) (01-08-2015)“…Endothelial nitric oxide (NO) signaling plays a physiological role in limiting obesity-associated insulin resistance and inflammation. This study was…”
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Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance
Published in Arteriosclerosis, thrombosis, and vascular biology (01-11-2008)“…OBJECTIVES—Obesity causes inflammation and insulin resistance in the vasculature as well as in tissues involved in glucose metabolism such as liver, muscle,…”
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Phase II study of uPAR-PET/CT for staging of primary breast cancer in comparison with ultrasound and fine needle biopsies
Published in Scientific reports (30-10-2024)“…Accurate initial staging of patients with breast cancer is essential for planning optimal treatment strategies. However, currently, no imaging modality is able…”
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Loss of Transforming Growth Factor Beta Signaling in Aortic Smooth Muscle Cells Causes Endothelial Dysfunction and Aortic Hypercontractility
Published in Arteriosclerosis, thrombosis, and vascular biology (01-06-2021)“…[Figure: see text]…”
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Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity
Published in Cell reports (Cambridge) (30-06-2020)“…Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue…”
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Transcatheter Aortic Valve Replacement and Impact of Subclinical Leaflet Thrombosis in Low-Risk Patients: LRT Trial 4-Year Outcomes
Published in Circulation. Cardiovascular interventions (01-05-2023)“…The LRT trial (Low-Risk Transcatheter Aortic Valve Replacement [TAVR]) demonstrated the safety and feasibility of TAVR in low-risk patients, with excellent 1-…”
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