Search Results - "Kim, Cy Hyun"
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Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats
Published in Journal of the American Society of Nephrology (01-05-2006)“…Aldosterone induces myocardial fibrosis and vascular inflammation via proinflammatory and profibrotic cytokines. The effect of spironolactone on renal…”
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2
Dextran-b-poly(L-histidine) copolymer nanoparticles for ph-responsive drug delivery to tumor cells
Published in International journal of nanomedicine (01-01-2013)“…Nanoparticles based on stimuli-sensitive drug delivery have been extensively investigated for tumor targeting. Among them, pH-responsive drug targeting using…”
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3
Synergistic effects of 5-aminolevulinic acid based photodynamic therapy and celecoxib via oxidative stress in human cholangiocarcinoma cells
Published in International journal of nanomedicine (01-01-2013)“…5-Aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has the potential to kill cancer cells via apoptotic or necrotic signals that are dependent on the…”
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4
LRRK2 regulates synaptic vesicle endocytosis
Published in Experimental cell research (10-06-2008)“…The leucine-rich repeat kinase 2 (LRRK2) has been identified as the defective gene at the PARK8 locus causing the autosomal dominant form of Parkinson's…”
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5
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25
Published in Experimental & molecular medicine (16-08-2013)“…Leucine-rich repeat kinase 2 ( LRRK2 ) is a gene that, upon mutation, causes autosomal-dominant familial Parkinson’s disease (PD). Yeast two-hybrid screening…”
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Antitumor activity of sorafenib-incorporated nanoparticles of dextran/poly(dl-lactide-co-glycolide) block copolymer
Published in Nanoscale research letters (27-01-2012)“…Sorafenib-incoporated nanoparticles were prepared using a block copolymer that is composed of dextran and poly( DL -lactide- co -glycolide) [Dex b LG] for…”
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7
LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity
Published in Experimental cell research (15-02-2010)“…LRRK2 is an autosomal dominant gene whose mutations cause familial Parkinson's disease (PD). The LRRK2 protein contains a functional kinase and a GTPase…”
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Effect of surfactant on 5-aminolevulinic acid uptake and PpIX generation in human cholangiocarcinoma cell
Published in European journal of pharmaceutics and biopharmaceutics (01-02-2012)“…PDT toxicity of ALA with surfactants. Cells were incubated for 4h with 0.25mM ALA in the presence of different amounts of surfactants and then irradiated under…”
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9
Ursodeoxycholic acid-conjugated chitosan for photodynamic treatment of HuCC-T1 human cholangiocarcinoma cells
Published in International journal of pharmaceutics (15-09-2013)“…•We synthesized novel chitosan conjugates (ChitoUDCA) composed of chitosan and ursodeoxycholic acid (UDCA).•We fabricated nanophotosensitizer for application…”
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10
Self-assembled nanoparticles of hyaluronic acid/poly( dl-lactide-co-glycolide) block copolymer
Published in Colloids and surfaces, B, Biointerfaces (01-02-2012)“…We synthesized block copolymer composed of hyaluronic acid (HA) and poly( dl-lactide-co-glycolide) (PLGA) (HAbLG) for antitumor targeting. 1H NMR was employed…”
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11
Doxorubicin-incorporated polymeric micelles composed of dextran-b-poly(DL-lactide-co-glycolide) copolymer
Published in International journal of nanomedicine (01-01-2011)“…Polymeric micelles using amphiphilic macromolecules are promising vehicles for antitumor targeting. In this study, we prepared anticancer agent-incorporated…”
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12
Effect of 5-aminolevulinic acid-encapsulate liposomes on photodynamic therapy in human cholangiocarcinoma cells
Published in Journal of nanoscience and nanotechnology (01-08-2014)“…Intracellular protoporphyrin IX (PpIX) generation following administration of 5-aminolevulinic acid (ALA) has been used in photodynamic therapy (PDT)…”
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13
Schisandrae fructus enhances myogenic differentiation and inhibits atrophy through protein synthesis in human myotubes
Published in International journal of nanomedicine (01-01-2016)“…Schisandrae fructus (SF) has recently been reported to increase skeletal muscle mass and inhibit atrophy in mice. We investigated the effect of SF extract on…”
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14
Aminolevulinic acid derivatives-based photodynamic therapy in human intra- and extrahepatic cholangiocarcinoma cells
Published in European journal of pharmaceutics and biopharmaceutics (01-11-2013)“…Hexyl-aminolevulinic acid (HALA) was compared with aminolevulinic acid (ALA) in terms of improving ALA-based photodynamic therapy (PDT) for human intra- and…”
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Preclinical evaluation of sorafenib-eluting stent for suppression of human cholangiocarcinoma cells
Published in International journal of nanomedicine (01-01-2013)“…Cholangiocarcinoma is a malignant tumor arising from the epithelium of the bile ducts. In this study, we prepared sorafenib-loaded biliary stents for potential…”
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Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells
Published in International journal of nanomedicine (01-01-2011)“…Cancer cells have been reported to exhibit an enhanced capacity for protoporphyrin IX (PpIX) synthesis facilitated by the administration of 5-aminolevulinic…”
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17
Spin-related tunneling through a nanostructured electric-magnetic barrier on the surface of a topological insulator
Published in Nanoscale research letters (27-01-2012)“…We investigate quantum tunneling through a single electric and/or magnetic barrier on the surface of a three-dimensional topological insulator. We found that…”
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Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase
Published in Biomedicines (16-10-2020)“…Viral replication of thymidine kinase deleted (tk−) vaccinia virus (VV) is attenuated in resting normal cells, enabling cancer selectivity, however,…”
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Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus
Published in Drug design, development and therapy (01-01-2018)“…Oncolytic poxvirus has shown promise in treating various solid tumors, such as liver cancer, and administration of oncolytic poxvirus via the hepatic artery…”
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Synergistic Anticancer Effects of Vorinostat and Epigallocatechin-3-Gallate against HuCC-T1 Human Cholangiocarcinoma Cells
Published in Evidence-based complementary and alternative medicine (01-01-2013)“…The aim of this study was to investigate the effect of the combination of vorinostat and epigallocatechin-3-gallate against HuCC-T1 human cholangiocarcinoma…”
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