Search Results - "Kim, Chongwoo A."

Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity by Seif, Elias, Kang, Jin Joo, Sasseville, Charles, Senkovich, Olga, Kaltashov, Alexander, Boulier, Elodie L., Kapur, Ibani, Kim, Chongwoo A., Francis, Nicole J.

“…Polycomb Group (PcG) proteins organize chromatin at multiple scales to regulate gene expression. A conserved Sterile Alpha Motif (SAM) in the Polycomb…”
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Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity by Turunen, Mikko, Spaeth, Jason M., Keskitalo, Salla, Park, Min Ju, Kivioja, Teemu, Clark, Alison D., Mäkinen, Netta, Gao, Fangjian, Palin, Kimmo, Nurkkala, Helka, Vähärautio, Anna, Aavikko, Mervi, Kämpjärvi, Kati, Vahteristo, Pia, Kim, Chongwoo A., Aaltonen, Lauri A., Varjosalo, Markku, Taipale, Jussi, Boyer, Thomas G.

“…Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at very high frequency (∼70%) in uterine leiomyomas. However,…”
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KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1 by Wong, Sarah J., Gearhart, Micah D., Taylor, Alexander B., Nanyes, David R., Ha, Daniel J., Robinson, Angela K., Artigas, Jason A., Lee, Oliver J., Demeler, Borries, Hart, P. John, Bardwell, Vivian J., Kim, Chongwoo A.

“…KDM2B recruits H2A-ubiquitinating activity of a non-canonical Polycomb Repression Complex 1 (PRC1.1) to CpG islands, facilitating gene repression. We…”
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Structure of the Polycomb Group Protein PCGF1 in Complex with BCOR Reveals Basis for Binding Selectivity of PCGF Homologs by Junco, Sarah E., Wang, Renjing, Gaipa, John C., Taylor, Alexander B., Schirf, Virgil, Gearhart, Micah D., Bardwell, Vivian J., Demeler, Borries, Hart, P. John, Kim, Chongwoo A.

“…Polycomb-group RING finger homologs (PCGF1, PCGF2, PCGF3, PCGF4, PCGF5, and PCGF6) are critical components in the assembly of distinct Polycomb repression…”
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Chromatin: Polycomb Group SAMs Unite by Kim, Chongwoo A., Francis, Nicole J.

“…Polycomb Group (PcG) proteins assemble a chromatin state that maintains developmental gene repression. A new study combining structure and in vivo analysis…”
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Structure and Role of BCOR PUFD in Noncanonical PRC1 Assembly and Disease by Wong, Sarah J, Senkovich, Olga, Artigas, Jason A, Gearhart, Micah D, Ilangovan, Udayar, Graham, David W, Abel, Kelsey N, Yu, Tianrong, Hinck, Andrew P, Bardwell, Vivian J, Kim, Chongwoo A

“…Polycomb repression complex 1 (PRC1) is a multiprotein assembly that regulates transcription. The Polycomb group ring finger 1 protein (PCGF1) is central in…”
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Adenovirus E1B 55-Kilodalton Protein Is a p53-SUMO1 E3 Ligase That Represses p53 and Stimulates Its Nuclear Export through Interactions with Promyelocytic Leukemia Nuclear Bodies by Pennella, Mario A, Liu, Yue, Woo, Jennifer L, Kim, Chongwoo A, Berk, Arnold J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Growth-Suppressive Function of the Polycomb Group Protein Polyhomeotic Is Mediated by Polymerization of Its Sterile Alpha Motif (SAM) Domain by Robinson, Angela K., Leal, Belinda Z., Chadwell, Linda V., Wang, Renjing, Ilangovan, Udayar, Kaur, Yogeet, Junco, Sarah E., Schirf, Virgil, Osmulski, Pawel A., Gaczynska, Maria, Hinck, Andrew P., Demeler, Borries, McEwen, Donald G., Kim, Chongwoo A.

“…Polyhomeotic (Ph), a member of the Polycomb Group (PcG), is a gene silencer critical for proper development. We present a previously unrecognized way of…”
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Polycomb Group Targeting through Different Binding Partners of RING1B C-Terminal Domain by Wang, Renjing, Taylor, Alexander B., Leal, Belinda Z., Chadwell, Linda V., Ilangovan, Udayar, Robinson, Angela K., Schirf, Virgil, Hart, P. John, Lafer, Eileen M., Demeler, Borries, Hinck, Andrew P., McEwen, Donald G., Kim, Chongwoo A.

“…RING1B, a Polycomb Group (PcG) protein, binds methylated chromatin through its association with another PcG protein called Polycomb (Pc). However, RING1B can…”
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Structural Organization of a Sex-comb-on-midleg/Polyhomeotic Copolymer by Kim, Chongwoo A., Sawaya, Michael R., Cascio, Duilio, Kim, Woojae, Bowie, James U.

“…The polycomb group proteins are required for the stable maintenance of gene repression patterns established during development. They function as part of large…”
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SAM domains: uniform structure, diversity of function by Kim, Chongwoo A, Bowie, James U

“…Sterile alpha motif (SAM) domains are known to exhibit diverse protein–protein interaction modes. They can form multiple self-association architectures and…”
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Characterization of Reversible Associations by Sedimentation Velocity with UltraScan by Demeler, Borries, Brookes, Emre, Wang, Renjing, Schirf, Virgil, Kim, Chongwoo A.

“…We compare here the utility of sedimentation velocity (SV) to sedimentation equilibrium (SE) analysis for the characterization of reversible systems. Genetic…”
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Oligomerization-dependent Association of the SAM Domains from Schizosaccharomyces pombe Byr2 and Ste4 by Ramachander, Ranjini, Kim, Chongwoo A, Phillips, Martin L, Mackereth, Cameron D, Thanos, Christopher D, McIntosh, Lawrence P, Bowie, James U

“…SAM ( s terile a lpha m otif) domains are protein-protein interaction modules found in a large number of regulatory proteins. Byr2 and Ste4 are two SAM…”
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The SAM domain of polyhomeotic forms a helical polymer by Bowie, James U, Kim, Chongwoo A, Gingery, Mari, Pilpa, Rosemarie M

“…The polycomb group (PcG) proteins are important in the maintenance of stable repression patterns during development. Several PcG members contain a…”
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Multiple polymer architectures of human polyhomeotic homolog 3 sterile alpha motif by Nanyes, David R., Junco, Sarah E., Taylor, Alexander B., Robinson, Angela K., Patterson, Nicolle L., Shivarajpur, Ambika, Halloran, Jonathan, Hale, Seth M., Kaur, Yogeet, Hart, P. John, Kim, Chongwoo A.

“…ABSTRACT The self‐association of sterile alpha motifs (SAMs) into a helical polymer architecture is a critical functional component of many different and…”
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A 2.2 Å resolution crystal structure of a designed zinc finger protein bound to DNA by Kim, Chongwoo A, Berg, Jeremy M

“…Considerable recent effort has been devoted to the design and selection of sequence-specific DNA binding proteins based on tandem arrays of Cys2His2 zinc…”
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Human Polyhomeotic Homolog 3 (PHC3) Sterile Alpha Motif (SAM) Linker Allows Open-Ended Polymerization of PHC3 SAM by Robinson, Angela K, Leal, Belinda Z, Nanyes, David R, Kaur, Yogeet, Ilangovan, Udayar, Schirf, Virgil, Hinck, Andrew P, Demeler, Borries, Kim, Chongwoo A

“…Sterile alpha motifs (SAMs) are frequently found in eukaryotic genomes. An intriguing property of many SAMs is their ability to self-associate, forming an…”
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Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression by Kim, Chongwoo A., Phillips, Martin L., Kim, Woojae, Gingery, Mari, Tran, Hoang H., Robinson, Michael A., Faham, Salem, Bowie, James U.

“…TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These…”
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Derepression by depolymerization; structural insights into the regulation of Yan by Mae by Qiao, Feng, Song, Haiyun, Kim, Chongwoo A, Sawaya, Michael R, Hunter, Jacob B, Gingery, Mari, Rebay, Ilaria, Courey, Albert J, Bowie, James U

“…Yan, an ETS family transcriptional repressor, is regulated by receptor tyrosine kinase signaling via the Ras/MAPK pathway. Phosphorylation and downregulation…”
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Identification of Nucleic Acid Binding Residues in the FCS Domain of the Polycomb Group Protein Polyhomeotic by Wang, Renjing, Ilangovan, Udayar, Leal, Belinda Z, Robinson, Angela K, Amann, Barbara T, Tong, Corey V, Berg, Jeremy M, Hinck, Andrew P, Kim, Chongwoo A

“…Polycomb group (PcG) proteins maintain the silent state of developmentally important genes. Recent evidence indicates that noncoding RNAs also play an…”
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