Search Results - "Kim, Caroline R."

Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine by Sun, Yizhi, Rahbani, Janane F., Jedrychowski, Mark P., Riley, Christopher L., Vidoni, Sara, Bogoslavski, Dina, Hu, Bo, Dumesic, Phillip A., Zeng, Xing, Wang, Alex B., Knudsen, Nelson H., Kim, Caroline R., Marasciullo, Anthony, Millán, José L., Chouchani, Edward T., Kazak, Lawrence, Spiegelman, Bruce M.

“…Adaptive thermogenesis has attracted much attention because of its ability to increase systemic energy expenditure and to counter obesity and diabetes 1 – 3 …”
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Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association by Tonsing-Carter, Eva, Hernandez, Kyle M, Kim, Caroline R, Harkless, Ryan V, Oh, Alyce, Bowie, Kathleen R, West-Szymanski, Diana C, Betancourt-Ponce, Mayra A, Green, Bradley D, Lastra, Ricardo R, Fleming, Gini F, Chandarlapaty, Sarat, Conzen, Suzanne D

“…Non-ER nuclear receptor activity can alter estrogen receptor (ER) chromatin association and resultant ER-mediated transcription. Consistent with GR modulation…”
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Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer by West, Diana C, Kocherginsky, Masha, Tonsing-Carter, Eva Y, Dolcen, D Nesli, Hosfield, David J, Lastra, Ricardo R, Sinnwell, Jason P, Thompson, Kevin J, Bowie, Kathleen R, Harkless, Ryan V, Skor, Maxwell N, Pierce, Charles F, Styke, Sarah C, Kim, Caroline R, de Wet, Larischa, Greene, Geoffrey L, Boughey, Judy C, Goetz, Matthew P, Kalari, Krishna R, Wang, Liewei, Fleming, Gini F, Györffy, Balázs, Conzen, Suzanne D

“…Although high glucocorticoid receptor (GR) expression in early-stage estrogen receptor (ER)-negative breast cancer is associated with shortened relapse-free…”
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CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling by Oguri, Yasuo, Shinoda, Kosaku, Kim, Hyeonwoo, Alba, Diana L., Bolus, W. Reid, Wang, Qiang, Brown, Zachary, Pradhan, Rachana N., Tajima, Kazuki, Yoneshiro, Takeshi, Ikeda, Kenji, Chen, Yong, Cheang, Rachel T., Tsujino, Kazuyuki, Kim, Caroline R., Greiner, Vanille Juliette, Datta, Ritwik, Yang, Christopher D., Atabai, Kamran, McManus, Michael T., Koliwad, Suneil K., Spiegelman, Bruce M., Kajimura, Shingo

“…Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the…”
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Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α by A, Mu, Wales, Thomas E., Zhou, Haixia, Draga-Coletă, Sorin-Valeriu, Gorgulla, Christoph, Blackmore, Katherine A., Mittenbühler, Melanie J., Kim, Caroline R., Bogoslavski, Dina, Zhang, Qiuyang, Wang, Zi-Fu, Jedrychowski, Mark P., Seo, Hyuk-Soo, Song, Kijun, Xu, Andrew Z., Sebastian, Luke, Gygi, Steven P., Arthanari, Haribabu, Dhe-Paganon, Sirano, Griffin, Patrick R., Engen, John R., Spiegelman, Bruce M.

“…Exercise benefits the human body in many ways. Irisin is secreted by muscle, increased with exercise, and conveys physiological benefits, including improved…”
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Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer by Agyeman, Abena S., Jun, Wesley J., Proia, David A., Kim, Caroline R., Skor, Maxwell N., Kocherginsky, Masha, Conzen, Suzanne D.

“…Targetable molecular drivers for triple-negative breast cancer (TNBC) have been difficult to identify; therefore, standard treatment remains limited to…”
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CUDC-907: An Oral HDAC/PI3K Dual Inhibitor with Strong Preclinical Efficacy in MCL Model by Boyle, Jordan N, Kim, Caroline R, Guo, Hui, Bell, Taylor, Huang, Shengjian, Li, Carrie J, Liu, Yang, Zhang, Hui, Wang, Jack, Zhang, Victoria, Ahmed, Makhdum, Lam, Laura T, Nomie, Krystle, Zhang, Liang, Zeng, Dongfeng, Wang, Michael

“…Introduction Mantle cell lymphoma (MCL) is an aggressive lymphoma with elevated B-cell receptor activity. Ibrutinib (IBN), a Bruton's tyrosine kinase (BTK)…”
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Pre-Clinical Evaluation of the PI3K-p110β/δ Inhibitor KA2237 in Mantle Cell Lymphoma by Huang, Shengjian, Nastoupil, Loretta J., Guo, Hui, Bell, Taylor, Ahmed, Makhdum, Li, Carrie J, Wang, Jack, Liu, Yang, Zhang, Victoria, Kim, Caroline R, Boyle, Jordan N, Lorence, Elizabeth A, Lam, Laura T, Chen, Zhihong, Zhang, Hui, Shuttleworth, Stephen Joseph, Nomie, Krystle, Wang, Michael, Zhang, Liang

“…Background: Mantle cell lymphoma (MCL) accounts for 6% of all non-Hodgkin lymphoma and is a therapeutic challenge. Phosphoinositide-3 kinase (PI3K) has been…”
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