Search Results - "Kim, Carla"

Non-small-cell lung cancers: a heterogeneous set of diseases by Chen, Zhao, Fillmore, Christine M., Hammerman, Peter S., Kim, Carla F., Wong, Kwok-Kin

“…Key Points Next-generation sequencing and other high-throughput analyses have begun to show the many different molecular and genetic subsets of non-small-cell…”
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Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis by Lee, Joo-Hyeon, Bhang, Dong Ha, Beede, Alexander, Huang, Tian Lian, Stripp, Barry R., Bloch, Kenneth D., Wagers, Amy J., Tseng, Yu-Hua, Ryeom, Sandra, Kim, Carla F.

“…Lung stem cells are instructed to produce lineage-specific progeny through unknown factors in their microenvironment. We used clonal 3D cocultures of…”
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The aging lung: Physiology, disease, and immunity by Schneider, Jaime L., Rowe, Jared H., Garcia-de-Alba, Carolina, Kim, Carla F., Sharpe, Arlene H., Haigis, Marcia C.

“…The population is aging at a rate never seen before in human history. As the number of elderly adults grows, it is imperative we expand our understanding of…”
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Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6 by Lee, Joo-Hyeon, Tammela, Tuomas, Hofree, Matan, Choi, Jinwook, Marjanovic, Nemanja Despot, Han, Seungmin, Canner, David, Wu, Katherine, Paschini, Margherita, Bhang, Dong Ha, Jacks, Tyler, Regev, Aviv, Kim, Carla F.

“…The diversity of mesenchymal cell types in the lung that influence epithelial homeostasis and regeneration is poorly defined. We used genetic lineage tracing,…”
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Mesenchymal Stem Cells Increase Alveolar Differentiation in Lung Progenitor Organoid Cultures by Leeman, Kristen T., Pessina, Patrizia, Lee, Joo-Hyeon, Kim, Carla F.

“…Lung epithelial cell damage and dysfunctional repair play a role in the development of lung disease. Effective repair likely requires the normal functioning of…”
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COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital by Thakur, Kiran T, Miller, Emily Happy, Glendinning, Michael D, Al-Dalahmah, Osama, Banu, Matei A, Boehme, Amelia K, Boubour, Alexandra L, Bruce, Samuel S, Chong, Alexander M, Claassen, Jan, Faust, Phyllis L, Hargus, Gunnar, Hickman, Richard A, Jambawalikar, Sachin, Khandji, Alexander G, Kim, Carla Y, Klein, Robyn S, Lignelli-Dipple, Angela, Lin, Chun-Chieh, Liu, Yang, Miller, Michael L, Moonis, Gul, Nordvig, Anna S, Overdevest, Jonathan B, Prust, Morgan L, Przedborski, Serge, Roth, William H, Soung, Allison, Tanji, Kurenai, Teich, Andrew F, Agalliu, Dritan, Uhlemann, Anne-Catrin, Goldman, James E, Canoll, Peter

“…Many patients with SARS-CoV-2 infection develop neurological signs and symptoms, though, to date, little evidence exists that primary infection of the brain is…”
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SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery by Mulay, Apoorva, Konda, Bindu, Garcia, Gustavo, Yao, Changfu, Beil, Stephen, Villalba, Jaquelyn M., Koziol, Colin, Sen, Chandani, Purkayastha, Arunima, Kolls, Jay. K., Pociask, Derek A., Pessina, Patrizia, de Aja, Julio Sainz, Garcia-de-Alba, Carolina, Kim, Carla F., Gomperts, Brigitte, Arumugaswami, Vaithilingaraja, Stripp, Barry R.

“…Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although…”
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Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors by Yu, Ming, Mazor, Tali, Huang, Hui, Huang, Hsuan-Ting, Kathrein, Katie L., Woo, Andrew J., Chouinard, Candace R., Labadorf, Adam, Akie, Thomas E., Moran, Tyler B., Xie, Huafeng, Zacharek, Sima, Taniuchi, Ichiro, Roeder, Robert G., Kim, Carla F., Zon, Leonard I., Fraenkel, Ernest, Cantor, Alan B.

“…Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian…”
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Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression by Xu, Chunxiao, Fillmore, Christine M., Koyama, Shohei, Wu, Hongbo, Zhao, Yanqiu, Chen, Zhao, Herter-Sprie, Grit S., Akbay, Esra A., Tchaicha, Jeremy H., Altabef, Abigail, Reibel, Jacob B., Walton, Zandra, Ji, Hongbin, Watanabe, Hideo, Jänne, Pasi A., Castrillon, Diego H., Rustgi, Anil K., Bass, Adam J., Freeman, Gordon J., Padera, Robert F., Dranoff, Glenn, Hammerman, Peter S., Kim, Carla F., Wong, Kwok-Kin

“…Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that biallelic inactivation of Lkb1 and Pten…”
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An airway organoid is forever by Paschini, Margherita, Kim, Carla F

“…In the last decade, the generation and maintenance of organotypic structures has been propelled to the center stage of biomedical research. In the lung, a…”
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Threat of resurgence or hope for global eradication of poliovirus? by Kim, Carla Y., Piamonte, Bernadeth, Allen, Rebecca, Thakur, Kiran T.

“…Recent outbreaks of poliomyelitis in countries that have been free of cases for decades highlight the challenges of eradicating polio in a globalized…”
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Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer by Kim, Carla F. Bender, Jackson, Erica L., Woolfenden, Amber E., Lawrence, Sharon, Babar, Imran, Vogel, Sinae, Crowley, Denise, Bronson, Roderick T., Jacks, Tyler

“…Injury models have suggested that the lung contains anatomically and functionally distinct epithelial stem cell populations. We have isolated such a regional…”
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EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors by Fillmore, Christine M., Xu, Chunxiao, Desai, Pooja T., Berry, Joanne M., Rowbotham, Samuel P., Lin, Yi-Jang, Zhang, Haikuo, Marquez, Victor E., Hammerman, Peter S., Wong, Kwok-Kin, Kim, Carla F.

“…A subset of lung cancer cells with EGFR or BRG1 mutations shows selective sensitivity to a combination of EZH2 inhibitors with topoisomerase II inhibitors such…”
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May the (Mechanical) Force Be with AT2 by Sainz de Aja, Julio, Kim, Carla F.

“…Idiopathic pulmonary fibrosis is a fatal disease involving destruction of the lung alveolar structure. In this issue of Cell, Wu et al. (2020) show that…”
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Airway Epithelial Progenitors Are Region Specific and Show Differential Responses to Bleomycin-Induced Lung Injury by Chen, Huaiyong, Matsumoto, Keitaro, Brockway, Brian L., Rackley, Craig R., Liang, Jiurong, Lee, Joo-Hyeon, Jiang, Dianhua, Noble, Paul W., Randell, Scott H., Kim, Carla F., Stripp, Barry R.

“…Mechanisms that regulate regional epithelial cell diversity and pathologic remodeling in airways are poorly understood. We hypothesized that regional…”
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Diverse cells at the origin of lung adenocarcinoma by Rowbotham, Samuel P., Kim, Carla F.

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Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia by Tropea, Kristen A, Leder, Eva, Aslam, Muhammad, Lau, Allison N, Raiser, David M, Lee, Joo-Hyeon, Balasubramaniam, Vivek, Fredenburgh, Laura E, Alex Mitsialis, S, Kourembanas, Stella, Kim, Carla F

“…Bronchopulmonary dysplasia (BPD) remains a major complication of prematurity resulting in significant morbidity and mortality. The pathology of BPD is…”
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Intersections of lung progenitor cells, lung disease and lung cancer by Kim, Carla F

“…The use of stem cell biology approaches to study adult lung progenitor cells and lung cancer has brought a variety of new techniques to the field of lung…”
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Requirement for Rac1 in a K-ras induced lung cancer in the mouse by Kissil, Joseph L, Walmsley, Marita J, Hanlon, Linda, Haigis, Kevin M, Bender Kim, Carla F, Sweet-Cordero, Alejandro, Eckman, Matthew S, Tuveson, David A, Capobianco, Anthony J, Tybulewicz, Victor L J, Jacks, Tyler

“…Given the prevalence of Ras mutations in human cancer, it is critical to understand the effector pathways downstream of oncogenic Ras leading to…”
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Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion by Dovey, Jennifer Shepard, Zacharek, Sima J, Kim, Carla F, Lees, Jacqueline A

“…Understanding the pathways that control epithelial carcinogenesis is vital to the development of effective treatments. The Polycomb group family member Bmi1 is…”
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