Search Results - "Kim, Bok Ryang"

Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury by Choi, Byung-Min, Kim, Bok-Ryang

“…Heme oxygenase (HO)-1 is a cytoprotective enzyme that is activated by various phytochemicals. We examined the ability of brazilin to upregulate HO-1 expression…”
Get full text

In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat by Hu, Rong, Hebbar, Vidya, Kim, Bok-Ryang, Chen, Chi, Winnik, Bozena, Buckley, Brian, Soteropoulos, Patricia, Tolias, Peter, Hart, Ronald P, Kong, A-N Tony

“…Sulforaphane (SUL) is one member of the isothiocyanate class of cancer chemopreventive compounds that has been shown to be effective in blocking initiation and…”
Get more information

Kaempferol Suppresses Cisplatin-Induced Apoptosis Via Inductions of Heme Oxygenase-1 and Glutamate-Cysteine Ligase Catalytic Subunit in HEI-OC1 cells by Gao, Shang Shang, Choi, Byung-Min, Chen, Xiao Yan, Zhu, Ri Zhe, Kim, Youngho, So, HongSeob, Park, Raekil, Sung, Meesook, Kim, Bok-Ryang

“…Purpose The present study was undertaken to elucidate the chemoprotective mechanism of kaempferol, which possesses anti-oxidative and anti-apoptotic…”
Get full text

Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC) by Keum, Young-Sam, Owuor, Edward D, Kim, Bok-Ryang, Hu, Rong, Kong, A N Tony

“…Phenethyl isothiocyanate (PEITC) has been of great interest as a promising cancer chemopreventive agent. To better understand its chemopreventive activity, we…”
Get full text

Anti-apoptotic effect of phloretin on cisplatin-induced apoptosis in HEI-OC1 auditory cells by Choi, Byung-Min, Chen, Xiao Yan, Gao, Shang Shang, Zhu, Rizhe, Kim, Bok-Ryang

“…Cisplatin is a highly effective chemotherapeutic agent, but it has significant ototoxic side effects. Apoptosis is an important mechanism of cochlear hair cell…”
Get full text

Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells by Choi, Byung-Min, Kim, Sung-Min, Park, Tae-Kwang, Li, Guang, Hong, Sung-Jae, Park, Raekil, Chung, Hun-Taeg, Kim, Bok-Ryang

“…Piperine is a major component of black pepper, Piper nigrum Linn, used widely in traditional medicine. In this study, we examined whether piperine could…”
Get full text

Sulforaphane induces glutathione S-transferase isozymes which detoxify aflatoxin B1-8,9-epoxide in AML 12 cells by Gao, Shang Shang, Chen, Xiao Yan, Zhu, Ri Zhe, Choi, Byung-Min, Kim, Bok-Ryang

“…The aflatoxin B1‐8,9‐epoxide (AFBO) is hepatocarcinogenic intermediate of aflatoxin B1 (AFB1) and is detoxified by glutathione S‐transferases (GSTs). In this…”
Get full text

Identification of a novel human Rad51 variant that promotes DNA strand exchange by Park, Jung-Young, Yoo, Han-Wook, Kim, Bok-Ryang, Park, Raekil, Choi, Sang-Yun, Kim, Youngho

“…Rad51 plays a key role in the repair of DNA double-strand breaks through homologous recombination, which is the central process in the maintenance of genomic…”
Get full text

Brazilin and the extract from Caesalpinia sappan L. protect oxidative injury through the expression of heme oxygenase-1 by Choi, Byung-Min, Lee, Ju-A., Gao, Shang Shang, Eun, Sang Yong, Kim, Young-Sup, Ryu, Shi-Yong, Choi, Yeon-Hee, Park, Raekil, Kwon, Dae Young, Kim, Bok-Ryang

“…In this study, we examined the protective effects of Caesalpinia sappan L. and its major component, brazilin, against tert‐butylhydroperoxide (t‐BHP)‐induced…”
Get full text

Metabolism of taxol by human hepatic microsomes and liver slices : participation of cytochrome P450 3A4 and an unknown P450 enzyme by HARRIS, J. W, RAHMAN, A, BOK-RYANG KIM, GUENGERICH, F. P, COLLINS, J. M

“…Incubation of taxol with human hepatic microsomal fractions or freshly isolated human liver slices yields three metabolite high performance liquid…”
Get full text

Benzo(a)pyrene-induced apoptotic death of mouse hepatoma Hepa1c1c7 cells via activation of intrinsic caspase cascade and mitochondrial dysfunction by Ko, Chang-Bo, Kim, Se-Jin, Park, Channy, Kim, Bok-Ryang, Shin, Chang-Ho, Choi, Sujinna, Chung, Sang-Young, Noh, Joon-Hwa, Jeun, Jin-Ho, Kim, Nam-Song, Park, Raekil

“…Benzo(a)pyrene (BaP), a potent carcinogen, has been shown to induce apoptosis via activation of caspase-3. However, the upstream of caspase-3 and other…”
Get full text

Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase) by Kim, Myung-Sunny, Cheong, Young-Pyo, So, Hong-Seob, Lee, Kang-Min, Kim, Tai-Yo, Oh, Jaymin, Chung, Yeon-Tai, Son, Yong, Kim, Bok-Ryang, Park, Raekil

“…Opiates, such as morphine, have been used extensively in the clinical management of pain due to their potent analgesic effect. Astrocytes, representing a major…”
Get full text

Structure-Related Inhibition of Human Hepatic Caffeine N3-Demethylation by Naturally Occurring Flavonoids by Lee, Ho, Yeom, Hyeyeong, Kim, Young Goo, Yoon, Chang No, Jin, Changbae, Choi, Jae Sue, Kim, Bok-Ryang, Kim, Dong-Hyun

“…The effects of flavonoids on caffeine N3-demethylation, a marker activity of CYP1A2, in human liver microsomes were investigated to elucidate the inhibition…”
Get full text

Activation of c-Jun N-terminal kinase 1 (JNK1) in mistletoe lectin II-induced apoptosis of human myeloleukemic U937 cells by Park, Raekil, Kim, Myung-Sunny, So, Hong-Seob, Jung, Byung-Hak, Moon, Sun-Rock, Chung, Sang-Young, Ko, Chang-Bo, Kim, Bok-Ryang, Chung, Hun-Taeg

“…Extracts of mistletoe (Viscum album var. coloratum) have been used for several decades as an anticancer immunomodulating agent in clinical fields. However, the…”
Get full text

Dual effects of phloretin on aflatoxin B 1 metabolism: Activation and detoxification of aflatoxin B 1 by Gao, Shang Shang, Chen, Xiao Yan, Zhu, Ri Zhe, Choi, Byung‐Min, Kim, Sun Jun, Kim, Bok‐Ryang

“…Abstract Typically, chemopreventive agents involve either induction of phase II detoxifying enzymes and/or inhibition of cytochrome P450 enzymes (CYPs) that…”
Get full text

Dual effects of phloretin on aflatoxin B1 metabolism: Activation and detoxification of aflatoxin B1 by Gao, Shang Shang, Chen, Xiao Yan, Zhu, Ri Zhe, Choi, Byung-Min, Kim, Sun Jun, Kim, Bok-Ryang

“…Typically, chemopreventive agents involve either induction of phase II detoxifying enzymes and/or inhibition of cytochrome P450 enzymes (CYPs) that are…”
Get full text

Mechanism of covalent adduct formation of aucubin to proteins by Kim, Dong-Hyun, Kim, Bok-Ryang, Kim, Ji-Yeon, Jeong, Yo-Chan

“…The iridoid glucoside aucubin can irreversibly bind to proteins through the formation of its aglycone. In view of a possible involvement of these protein…”
Get full text

Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane by KIM, Bok-Ryang, HU, Rong, KEUM, Young-Sam, HEBBAR, Vidya, SHEN, Guoxiang, NAIR, Sujit S, KONG, A.-N. Tony

“…Sulforaphane (SFN) and its N-acetyl-L-cysteine (NAC) conjugate are effective inhibitors of tumorigenesis in animal models. These compounds induce the…”
Get full text

The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells by Hu, Rong, Kim, Bok Ryang, Chen, Chi, Hebbar, Vidya, Kong, A.-N.Tony

“…Phenethyl isothiocyanate (PEITC) is a potential chemopreventive agent that is present naturally in widely consumed vegetables, especially in watercress. It has…”
Get full text

Toxicogenomics of resveratrol in rat liver by Hebbar, Vidya, Shen, Guoxiang, Hu, Rong, Kim, Bok-Ryang, Chen, Chi, Korytko, Peter J., Crowell, James A., Levine, Barry S., Kong, A.-N. Tony

“…Resveratrol, a polyphenolic compound found in grape skin and peanuts has been shown to prevent many diseases including cardiovascular diseases and cancer. To…”
Get full text