Search Results - "Kim, Arianna L"

Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms by Athar, Mohammad, Back, Jung Ho, Kopelovich, Levy, Bickers, David R., Kim, Arianna L.

“…Plant-derived polyphenolic compounds, such as the stilbene resveratrol ( trans-3,4′,5-trihydroxystilbene), have been identified as potent anti-cancer agents…”
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Sonic hedgehog signaling in Basal cell nevus syndrome by Athar, Mohammad, Li, Changzhao, Kim, Arianna L, Spiegelman, Vladimir S, Bickers, David R

“…The hedgehog (Hh) signaling pathway is considered to be a major signal transduction pathway during embryonic development, but it usually shuts down after…”
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Transcriptome Analysis Identifies the Dysregulation of Ultraviolet Target Genes in Human Skin Cancers by Shen, Yao, Kim, Arianna L, Du, Rong, Liu, Liang

“…Exposure to ultraviolet radiation (UVR) is a major risk factor for both melanoma and non-melanoma skin cancers. In addition to its mutagenic effect, UVR can…”
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The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma by Morgado-Palacin, Lucia, Brown, Jessie A., Martinez, Thomas F., Garcia-Pedrero, Juana M., Forouhar, Farhad, Quinn, S. Aidan, Reglero, Clara, Vaughan, Joan, Heydary, Yasamin Hajy, Donaldson, Cynthia, Rodriguez-Perales, Sandra, Allonca, Eva, Granda-Diaz, Rocio, Fernandez, Agustin F., Fraga, Mario F., Kim, Arianna L., Santos-Juanes, Jorge, Owens, David M., Rodrigo, Juan P., Saghatelian, Alan, Ferrando, Adolfo A.

“…The TINCR ( T erminal differentiation- I nduced N on- C oding R NA) gene is selectively expressed in epithelium tissues and is involved in the control of human…”
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Author Correction: Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1+/−/ODC transgenic mice by Li, Changzhao, Mishra, Bharat, Kashyap, Mahendra, Weng, Zhiping, Andrabi, Shaida A., Mukhtar, Shahid M., Kim, Arianna L., Bickers, David R., Kopelovich, Levy, Athar, Mohammad

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Cancer Cell Survival Following DNA Damage-mediated Premature Senescence Is Regulated by Mammalian Target of Rapamycin (mTOR)-dependent Inhibition of Sirtuin 1 by Back, Jung Ho, Rezvani, Hamid Reza, Zhu, Yucui, Guyonnet-Duperat, Véronique, Athar, Mohammad, Ratner, Desiree, Kim, Arianna L.

“…DNA-damaging agents can induce premature senescence in cancer cells, which contributes to the static effects of cancer. However, senescent cancer cells may…”
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Resveratrol-Mediated Downregulation of Rictor Attenuates Autophagic Process and Suppresses UV-Induced Skin Carcinogenesis by Back, Jung H., Zhu, Yucui, Calabro, Alyssa, Queenan, Craig, Kim, Audrey S., Arbesman, Joshua, Kim, Arianna L.

“…Macroautophagy is a cellular response to various environmental stresses that ensures lysosomal degradation of long‐lived and damaged proteins and cellular…”
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Resveratrol Targets Transforming Growth Factor-β2 Signaling to Block UV-Induced Tumor Progression by Kim, Kwang Ho, Back, Jung Ho, Zhu, Yucui, Arbesman, Josh, Athar, Mohammad, Kopelovich, Levy, Kim, Arianna L., Bickers, David R.

“…Resveratrol (RES) is a potent anti-cancer agent. We have previously reported that RES arrests the growth of invasive human A431 squamous cell carcinoma (SCC)…”
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The expanding relevance of nuclear mTOR in carcinogenesis by Back, Jung H., Kim, Arianna L.

“…Deregulated mTOR signaling drives the growth of various human cancers, making mTOR a major target for development of cancer chemotherapeutics. The role of mTOR…”
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Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome by Chaudhary, Sandeep C, Tang, Xiuwei, Arumugam, Aadithya, Li, Changzhao, Srivastava, Ritesh K, Weng, Zhiping, Xu, Jianmin, Zhang, Xiao, Kim, Arianna L, McKay, Kristopher, Elmets, Craig A, Kopelovich, Levy, Bickers, David R, Athar, Mohammad

“…Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disorder that is due, in large measure, to aberrant Shh signaling driven by mutations…”
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Correction: Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation by Liu, Liang, Rezvani, Hamid Reza, Back, Jung Ho, Hosseini, Mohsen, Tang, Xiuwei, Zhu, Yucui, Mahfouf, Walid, Raad, Houssam, Ragi, Grace, Athar, Mohammad, Kim, Arianna L, Bickers, David R

“…[This corrects the article DOI: 10.1371/journal.pone.0097245.]…”
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Role of p38 MAPK in UVB-Induced Inflammatory Responses in the Skin of SKH-1 Hairless Mice by Kim, Arianna L., Labasi, Jeffrey M., Zhu, Yucui, Tang, Xiuwei, McClure, Kim, Gabel, Christopher A., Athar, Mohammad, Bickers, David R.

“…The p38 mitogen-activated protein kinase (MAPK) signaling pathway is activated by numerous inflammatory mediators and environmental stresses. We assessed the…”
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Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis by ATHAR, Mohammad, CHENGXIN LI, BICKERS, David R, JINGWU XIE, XIUWEI TANG, SUMIN CHI, XIAOLI ZHANG, KIM, Arianna L, TYRING, Stephen K, KOPELOVICH, Levy, HEBERT, Jennifer, EPSTEIN, Ervin H

“…Abnormal activation of the hedgehog-signaling pathway is the pivotal abnormality driving the growth of basal cell carcinomas (BCCs), the most common type of…”
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Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling by Kim, Hyunmi, Casta, Alexandre, Tang, Xiuwei, Luke, Courtney T, Kim, Arianna L, Bickers, David R, Athar, Mohammad, Christiano, Angela M

“…In order to model squamous cell carcinoma development in vivo, researchers have long preferred hairless mouse models such as SKH-1 mice that have traditionally…”
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DDB1 is essential for genomic stability in developing epidermis by Cang, Yong, Zhang, Jianxuan, Nicholas, Sally A, Kim, Arianna L, Zhou, Pengbo, Goff, Stephen P

“…The mammalian epidermis is maintained by proliferation and differentiation of epidermal progenitor cells in a stereotyped developmental program. Here we report…”
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Inhibition of p38 MAPK signaling augments skin tumorigenesis via NOX2 driven ROS generation by Liu, Liang, Rezvani, Hamid Reza, Back, Jung Ho, Hosseini, Mohsen, Tang, Xiuwei, Zhu, Yucui, Mahfouf, Walid, Raad, Houssam, Ragi, Grace, Athar, Mohammad, Kim, Arianna L, Bickers, David R

“…p38 mitogen-activated protein kinases (MAPKs) respond to a wide range of extracellular stimuli. While the inhibition of p38 signaling is implicated in the…”
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SOX9 Transcriptionally Regulates mTOR-Induced Proliferation of Basal Cell Carcinomas by Kim, Arianna L., Back, Jung Ho, Chaudhary, Sandeep C., Zhu, Yucui, Athar, Mohammad, Bickers, David R.

“…Currently available smoothened targeted therapies in patients with basal cell nevus syndrome are associated with substantial tumor recurrence and clinical…”
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Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice by Tang, Xiuwei, Kim, Arianna L, Feith, David J, Pegg, Anthony E, Russo, Justin, Zhang, Hong, Aszterbaum, Michelle, Kopelovich, Levy, Epstein, Jr, Ervin H, Bickers, David R, Athar, Mohammad

“…Solar ultraviolet B (UVB) radiation induces cutaneous ornithine decarboxylase (ODC), the first enzyme in the polyamine-biosynthesis pathway, which drives…”
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Targeting the Jak/Signal Transducer and Activator of Transcription 3 Pathway with Ruxolitinib in a Mouse Model of Recessive Dystrophic Epidermolysis Bullosa–Squamous Cell Carcinoma by Jacków, Joanna, Rami, Avina, Hayashi, Ryota, Hansen, Corey, Guo, Zongyou, DeLorenzo, Dominick, Pappalardo, Alberto, Alvarez Cespedes, David, Kim, Arianna L., Perez-Lorenzo, Rolando, Owens, David M., Christiano, Angela M.

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Resveratrol: A review of preclinical studies for human cancer prevention by Athar, Mohammad, Back, Jung Ho, Tang, Xiuwei, Kim, Kwang Ho, Kopelovich, Levy, Bickers, David R., Kim, Arianna L.

“…The search for novel and effective cancer chemopreventive agents has led to the identification of various naturally occurring compounds one of which is…”
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