Search Results - "Kilpeläinen, Tommi"

5‑Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions by Pätsi, Henri T., Kilpeläinen, Tommi P., Jumppanen, Mikael, Uhari-Väänänen, Johanna, Wielendaele, Pieter Van, De Lorenzo, Francesca, Cui, Hengjing, Auno, Samuli, Saharinen, Janne, Seppälä, Erin, Sipari, Nina, Savinainen, Juha, De Meester, Ingrid, Lambeir, Anne-Marie, Lahtela-Kakkonen, Maija, Myöhänen, Timo T., Wallén, Erik A. A.

“…A series of novel 5-aminothiazole-based ligands for prolyl oligopeptidase (PREP) comprise selective, potent modulators of the protein–protein interaction…”
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Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α‑Synuclein Mouse Models of Parkinson’s Disease by Kilpeläinen, Tommi P., Pätsi, Henri T., Svarcbahs, Reinis, Julku, Ulrika H., Eteläinen, Tony S., Cui, Hengjing, Auno, Samuli, Sipari, Nina, Norrbacka, Susanna, Leino, Teppo O., Jäntti, Maria, Myöhänen, Timo T., Wallén, Erik A. A.

“…Prolyl oligopeptidase (PREP) is a widely distributed serine protease in the human body cleaving proline-containing peptides; however, recent studies suggest…”
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New tricks of prolyl oligopeptidase inhibitors – A common drug therapy for several neurodegenerative diseases by Svarcbahs, Reinis, Julku, Ulrika, Kilpeläinen, Tommi, Kyyrö, Mirva, Jäntti, Maria, Myöhänen, Timo T.

“…[Display omitted] Changes in prolyl oligopeptidase (PREP) expression levels, protein distribution, and activity correlate with aging and are reported in many…”
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Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model by Eteläinen, Tony S., Kilpeläinen, Tommi P., Ignatius, Adele, Auno, Samuli, De Lorenzo, Francesca, Uhari-Väänänen, Johanna K., Julku, Ulrika H., Myöhänen, Timo T.

“…Parkinson's disease (PD) is characterized by degeneration of nigrostriatal dopaminergic neurons and accumulation of α-synuclein (αSyn) as Lewy bodies…”
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The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy by Kilpeläinen, Tommi P., Hellinen, Laura, Vrijdag, Johannes, Yan, Xu, Svarcbahs, Reinis, Vellonen, Kati-Sisko, Lambeir, Anne-Marie, Huttunen, Henri, Urtti, Arto, Wallen, Erik A.A, Myöhänen, Timo T.

“…•Prolyl oligopeptidase (PREP) inhibition decreases α-synuclein aggregation and induce autophagy in cells and in vivo.•These effects are related to…”
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Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A by Svarcbahs, Reinis, Jäntti, Maria, Kilpeläinen, Tommi, Julku, Ulrika H., Urvas, Lauri, Kivioja, Saara, Norrbacka, Susanna, Myöhänen, Timo T.

“…[Display omitted] Prolyl oligopeptidase (PREP) is a serine protease that has been studied particularly in the context of neurodegenerative diseases for decades…”
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Behavioural and dopaminergic changes in double mutated human A30PA53T alpha-synuclein transgenic mouse model of Parkinson´s disease by Kilpeläinen, Tommi, Julku, Ulrika H., Svarcbahs, Reinis, Myöhänen, Timo T.

“…Alpha-synuclein (aSyn) is the main component of Lewy bodies, the histopathological marker in Parkinson’s disease (PD), and point mutations and multiplications…”
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2‑Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors by Pätsi, Henri T, Kilpeläinen, Tommi P, Auno, Samuli, Dillemuth, Pyry M. J, Arja, Khaled, Lahtela-Kakkonen, Maija K, Myöhänen, Timo T, Wallén, Erik A. A

“…Different five-membered nitrogen-containing heteroaromatics in the position of the typical electrophilic group in prolyl oligopeptidase (PREP) inhibitors were…”
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Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors by Kilpeläinen, Tommi P, Tyni, Jonna K, Lahtela-Kakkonen, Maija K, Eteläinen, Tony S, Myöhänen, Timo T, Wallén, Erik A. A

“…4-Phenylbutanoyl-aminoacyl-2­(S)-tetrazolylpyrrolidines were studied as prolyl oligopeptidase inhibitors. The compounds were more potent than expected from the…”
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Prolyl oligopeptidase inhibition reduces alpha‐synuclein aggregation in a cellular model of multiple system atrophy by Cui, Hengjing, Kilpeläinen, Tommi, Zouzoula, Lydia, Auno, Samuli, Trontti, Kalevi, Kurvonen, Sampo, Norrbacka, Susanna, Hovatta, Iiris, Jensen, Poul Henning, Myöhänen, Timo T.

“…Multiple system atrophy (MSA) is a fatal neurodegenerative disease where the histopathological hallmark is glial cytoplasmic inclusions in oligodendrocytes,…”
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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy by Eteläinen, Tony S, Silva, M Catarina, Uhari-Väänänen, Johanna K, De Lorenzo, Francesca, Jäntti, Maria H, Cui, Hengjing, Chavero-Pieres, Marta, Kilpeläinen, Tommi, Mechtler, Christina, Svarcbahs, Reinis, Seppälä, Erin, Savinainen, Juha R, Puris, Elena, Fricker, Gert, Gynther, Mikko, Julku, Ulrika H, Huttunen, Henri J, Haggarty, Stephen J, Myöhänen, Timo T

“…Tauopathies are neurodegenerative diseases that are characterized by accumulation of hyperphosphorylated tau protein, higher-order aggregates, and tau…”
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Novel Small‐Molecular Ligands for Prolyl Oligopeptidase to Combat Tauopathies by Eteläinen, Tony, Pätsi, Henri, Uhari‐Väänänen, Johanna, Aikkila, Hannes, Cui, Hengjing, De Lorenzo, Francesca, Kilpeläinen, Tommi, Julku, Ulrika, Wallén, Erik A.A., Myöhänen, Timo T

“…Background Tauopathies that include e.g. frontotemporal dementia and Alzheimer’s disease, are neurodegenerative diseases characterized by accumulation of…”
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