Search Results - "Kilpatrick, J."

Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent by Kilpatrick, Gavin J

“…A program to identify novel intravenous sedatives with a short and predictable duration of action was initiated in the late 1990's by Glaxo Wellcome. The…”
Get full text

Achievements and obstacles of remyelinating therapies in multiple sclerosis by Stangel, Martin, Kuhlmann, Tanja, Matthews, Paul M., Kilpatrick, Trevor J.

“…Key Points CNS remyelination serves to limit and repair the damage in demyelinating diseases such as multiple sclerosis (MS) Several intrinsic molecular…”
Get full text

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner by Mitew, Stanislaw, Gobius, Ilan, Fenlon, Laura R., McDougall, Stuart J., Hawkes, David, Xing, Yao Lulu, Bujalka, Helena, Gundlach, Andrew L., Richards, Linda J., Kilpatrick, Trevor J., Merson, Tobias D., Emery, Ben

“…Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree…”
Get full text

Sound symbolism in Japanese names: Machine learning approaches to gender classification by Ngai, Chun Hau, Kilpatrick, Alexander J, Ćwiek, Aleksandra

“…This study investigates the sound symbolic expressions of gender in Japanese names with machine learning algorithms. The main goal of this study is to explore…”
Get full text

Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS by Koenning, Matthias, Jackson, Stacey, Hay, Curtis M, Faux, Clare, Kilpatrick, Trevor J, Willingham, Melanie, Emery, Ben

“…Although the transcription factors required for the generation of oligodendrocytes and CNS myelination during development have been relatively well…”
Get full text

The Relationship Between Deer Density, Tick Abundance, and Human Cases of Lyme Disease in a Residential Community by Kilpatrick, Howard J., Labonte, Andrew M., Stafford, Kirby C.

“…White-tailed deer (Odocoileus virginianus Zimmerman), serve as the primary host for the adult blacklegged tick (Ixodes scapularis Say), the vector for Lyme…”
Get full text

Maternal Mortality in the Twenty-First Century by Ozimek, John A., DO, MS, Kilpatrick, Sarah J., MD, PhD

“…Maternal mortality plagues much of the world. There were 303,000 maternal deaths in 2015 representing an overall global maternal mortality ratio of 216…”
Get full text

Adult neural precursor cells from the subventricular zone contribute significantly to oligodendrocyte regeneration and remyelination by Xing, Yao Lulu, Röth, Philipp T, Stratton, Jo Anne S, Chuang, Bernard H A, Danne, Jill, Ellis, Sarah L, Ng, Sze Woei, Kilpatrick, Trevor J, Merson, Tobias D

“…Parenchymal oligodendrocyte progenitor cells (pOPCs) are considered the principal cell type responsible for oligodendrogenesis and remyelinaton in…”
Get full text

The Tolerogenic Influence of Dexamethasone on Dendritic Cells Is Accompanied by the Induction of Efferocytosis, Promoted by MERTK by Li, Vivien, Binder, Michele D, Kilpatrick, Trevor J

“…Many treatments for autoimmune diseases, caused by the loss of immune self-tolerance, are broadly immunosuppressive. Dendritic cells (DCs) can be induced to…”
Get full text

Oligodendroglial expression of TrkB independently regulates myelination and progenitor cell proliferation by Wong, Agnes W, Xiao, Junhua, Kemper, Dennis, Kilpatrick, Trevor J, Murray, Simon S

“…The neurotrophin brain-derived neurotrophic factor (BDNF) has been implicated in regulating CNS myelination. BDNF mutant mice exhibit a hypomyelinating…”
Get full text

Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures by Galson, Jacob D, Schaetzle, Sebastian, Bashford-Rogers, Rachael J M, Raybould, Matthew I J, Kovaltsuk, Aleksandr, Kilpatrick, Gavin J, Minter, Ralph, Finch, Donna K, Dias, Jorge, James, Louisa K, Thomas, Gavin, Lee, Wing-Yiu Jason, Betley, Jason, Cavlan, Olivia, Leech, Alex, Deane, Charlotte M, Seoane, Joan, Caldas, Carlos, Pennington, Daniel J, Pfeffer, Paul, Osbourn, Jane

“…Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19 patients from the UK reveals a stereotypical naive immune response to…”
Get full text

Gait and balance impairment in early multiple sclerosis in the absence of clinical disability by Martin, C L, Phillips, B A, Kilpatrick, T J, Butzkueven, H, Tubridy, N, McDonald, E, Galea, M P

“…This study evaluated the gait and balance performance of two clinically distinct groups of recently diagnosed and minimally impaired multiple sclerosis (MS)…”
Get full text

Sun exposure and vitamin D are independent risk factors for CNS demyelination by LUCAS, R. M, PONSONBY, A.-L, VAN DER MEI, I, WILLIAMS, D, MCMICHAEL, A. J, DEAR, K, VALERY, P. C, PENDER, M. P, TAYLOR, B. V, KILPATRICK, T. J, DWYER, T, COULTHARD, A, CHAPMAN, C

“…To examine whether past and recent sun exposure and vitamin D status (serum 25-hydroxyvitamin D [25(OH)D] levels) are associated with risk of first…”
Get full text

Opportunities for improvement in care among women with severe maternal morbidity by Ozimek, John A., DO, Eddins, Rhonda M., RN, Greene, Naomi, PhD, Karagyozyan, Daniela, MD, Pak, Sujane, RN, Wong, Melissa, MD, Zakowski, Mark, MD, Kilpatrick, Sarah J., MD, PhD

“…Background Severe maternal morbidity is increasing in the United States and has been estimated to occur in up to 1.3% of all deliveries. A standardized,…”
Get full text

Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS by Nguyen, Linda T., Aprico, Andrea, Nwoke, Eze, Walsh, Alexander D., Blades, Farrah, Avneri, Raphael, Martin, Elodie, Zalc, Bernard, Kilpatrick, Trevor J., Binder, Michele D.

“…Abstract Background Microglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and…”
Get full text

Confirmed severe maternal morbidity is associated with high rate of preterm delivery by Kilpatrick, Sarah J., MD, PhD, Abreo, Anisha, MPH, Gould, Jeffrey, MD, Greene, Naomi, PhD, Main, Elliot K., MD

“…Background Because severe maternal morbidity (SMM) is increasing in the United States, affecting up to 50,000 women per year, there was a recent call to review…”
Get full text

Impact of fertility treatment on severe maternal morbidity by Wang, Erica T., M.D., M.A.S, Ozimek, John A., D.O, Greene, Naomi, Ph.D, Ramos, Lauren, M.D, Vyas, Nina, B.S, Kilpatrick, Sarah J., M.D., Ph.D, Pisarska, Margareta D., M.D

“…Objective To determine if fertility treatment is associated with increased risk of severe maternal morbidity (SMM) compared with spontaneous pregnancies…”
Get full text

Optic nerve diffusion tensor imaging after acute optic neuritis predicts axonal and visual outcomes by van der Walt, Anneke, Kolbe, Scott C, Wang, Yejun E, Klistorner, Alexander, Shuey, Neil, Ahmadi, Gelareh, Paine, Mark, Marriott, Mark, Mitchell, Peter, Egan, Gary F, Butzkueven, Helmut, Kilpatrick, Trevor J

“…Early markers of axonal and clinical outcomes are required for early phase testing of putative neuroprotective therapies for multiple sclerosis (MS). To assess…”
Get full text

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis by STEIN, M. S, LIU, Y, KILPATRICK, T. J, GRAY, O. M, BAKER, J. E, KOLBE, S. C, DITCHFIELD, M. R, EGAN, G. F, MITCHELL, P. J, HARRISON, L. C, BUTZKUEVEN, H

“…Higher latitude, lower ultraviolet exposure, and lower serum 25-hydroxyvitamin D (25OHD) correlate with higher multiple sclerosis (MS) prevalence, relapse…”
Get full text

Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions by Sabo, Jennifer K, Aumann, Tim D, Merlo, Daniel, Kilpatrick, Trevor J, Cate, Holly S

“…Remyelination of the CNS involves the regeneration of mature oligodendrocytes by endogenous oligodendrocyte progenitor cells (OPCs). Previous studies have…”
Get full text