Search Results - "Killoy, Kelby M"

Evaluation of the NAD+ biosynthetic pathway in ALS patients and effect of modulating NAD+ levels in hSOD1-linked ALS mouse models by Harlan, Benjamin A., Killoy, Kelby M., Pehar, Mariana, Liu, Liping, Auwerx, Johan, Vargas, Marcelo R.

“…Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons. Astrocytes from diverse ALS models induce motor neuron death…”
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FABP7 upregulation induces a neurotoxic phenotype in astrocytes by Killoy, Kelby M., Harlan, Benjamin A., Pehar, Mariana, Vargas, Marcelo R.

“…Fatty acid binding proteins (FABPs) are key regulators of lipid metabolism, energy homeostasis, and inflammation. They participate in fatty acid metabolism by…”
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Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis by Pehar, Mariana, Harlan, Benjamin A, Killoy, Kelby M, Vargas, Marcelo R

“…Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motor neurons in the spinal cord, brain stem, and motor cortex. The…”
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Effects of RAGE inhibition on the progression of the disease in hSOD1G93A ALS mice by Liu, Liping, Killoy, Kelby M., Vargas, Marcelo R., Yamamoto, Yasuhiko, Pehar, Mariana

“…Astrocytes play a key role in the progression of amyotrophic lateral sclerosis (ALS) by actively inducing the degeneration of motor neurons. Motor neurons…”
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Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration by Pehar, Mariana, Harlan, Benjamin A, Killoy, Kelby M, Vargas, Marcelo R

“…Nicotinamide adenine dinucleotide (NAD ) participates in redox reactions and NAD -dependent signaling processes, which involve the cleavage of NAD coupled to…”
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Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS‐linked mutant SOD1 by Harlan, Benjamin A., Pehar, Mariana, Killoy, Kelby M., Vargas, Marcelo R.

“…ABSTRACT Sirtuins (SIRTs) are NAD+‐dependent deacylases that play a key role in transcription, DNA repair, metabolism, and oxidative stress resistance…”
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NR1D1 downregulation in astrocytes induces a phenotype that is detrimental to cocultured motor neurons by Killoy, Kelby M., Harlan, Benjamin A., Pehar, Mariana, Vargas, Marcelo R.

“…Nuclear receptor subfamily 1 group D member 1 (NR1D1, also known as Rev‐erbα) is a nuclear transcription factor that is part of the molecular clock encoding…”
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Altered expression of clock and clock‐controlled genes in a hSOD1‐linked amyotrophic lateral sclerosis mouse model by Killoy, Kelby M., Pehar, Mariana, Harlan, Benjamin A., Vargas, Marcelo R.

“…Most physiological processes in mammals are subjected to daily oscillations that are governed by a circadian system. The circadian rhythm orchestrates…”
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Decreased glutathione levels cause overt motor neuron degeneration in hSOD1WT over-expressing mice by Killoy, Kelby M., Harlan, Benjamin A., Pehar, Mariana, Helke, Kristi L., Johnson, Jeffrey A., Vargas, Marcelo R.

“…Mutations in Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal disorder characterized by the progressive…”
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Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75 NTR and RAGE Signaling in ALS by Kim, Mi Jin, Vargas, Marcelo R, Harlan, Benjamin A, Killoy, Kelby M, Ball, Lauren E, Comte-Walters, Susana, Gooz, Monika, Yamamoto, Yasuhiko, Beckman, Joseph S, Barbeito, Luis, Pehar, Mariana

“…Glycating stress can occur together with oxidative stress during neurodegeneration and contribute to the pathogenic mechanism. Nerve growth factor (NGF)…”
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Effects of RAGE inhibition on the progression of the disease in hSOD1 G93A ALS mice by Liu, Liping, Killoy, Kelby M, Vargas, Marcelo R, Yamamoto, Yasuhiko, Pehar, Mariana

“…Astrocytes play a key role in the progression of amyotrophic lateral sclerosis (ALS) by actively inducing the degeneration of motor neurons. Motor neurons…”
Get full text

FABP7 up-regulation induces a neurotoxic phenotype in astrocytes by Killoy, Kelby M., Harlan, Benjamin A., Pehar, Mariana, Vargas, Marcelo R.

“…Fatty acid binding proteins (FABPs) are key regulators of lipid metabolism, energy homeostasis and inflammation. They participate in fatty acid metabolism by…”
Get full text

Decreased glutathione levels cause overt motor neuron degeneration in hSOD1WT overexpressing mice by Killoy, Kelby M., Harlan, Benjamin A., Pehar, Mariana, Helke, Kristi L., Johnson, Jeffrey A., Vargas, Marcelo R.

“…Mutations in Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal disorder characterized by the progressive…”
Get full text

Decreased glutathione levels cause overt motor neuron degeneration in hSOD1 WT over-expressing mice by Killoy, Kelby M, Harlan, Benjamin A, Pehar, Mariana, Helke, Kristi L, Johnson, Jeffrey A, Vargas, Marcelo R

“…Mutations in Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal disorder characterized by the progressive…”
Get full text