Search Results - "Killian, Maudi"
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HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time
Published in Proceedings of the National Academy of Sciences - PNAS (17-12-2013)“…The source and dynamics of persistent HIV-1 during long-term combinational antiretroviral therapy (cART) are critical to understanding the barriers to curing…”
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The Distribution of HIV DNA and RNA in Cell Subsets Differs in Gut and Blood of HIV-Positive Patients on ART: Implications for Viral Persistence
Published in The Journal of infectious diseases (15-10-2013)“…Even with optimal antiretroviral therapy, human immunodeficiency virus (HIV) persists in plasma, blood cells, and tissues. To develop new therapies, it is…”
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Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adults
Published in PloS one (26-03-2015)“…Gastrointestinal T lymphocytes are critical for mucosal immunity and HIV pathogenesis, yet little is known about normal T cell numbers and phenotypes in…”
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Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy
Published in The Journal of infectious diseases (15-08-2015)“…Background. The stability of the human immunodeficiency virus type 1 (HIV-1) reservoir and the contribution of cellular proliferation to the maintenance of the…”
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Hematopoietic Precursor Cells Isolated From Patients on Long-term Suppressive HIV Therapy Did Not Contain HIV-1 DNA
Published in The Journal of infectious diseases (01-07-2012)“…Background. We address the key emerging question of whether Lin - /CD34 + hematopoietic precursor cells (HPCs) represent an important latent reservoir of human…”
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A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells
Published in AIDS (London) (28-01-2014)“…We compared different techniques for measuring gut HIV reservoirs and assessed for HIV in non-CD4 T cells. HIV DNA levels were similar when measured from…”
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Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses
Published in AIDS (London) (28-11-2006)“…HIV-infected subjects are at increased risk for myocardial infarction. The mechanism of this increased risk remains unclear. Since cytomegalovirus (CMV)…”
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Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration
Published in The Journal of clinical investigation (01-09-2012)“…Progress in neurodegenerative disease research is hampered by the lack of biomarkers of neuronal dysfunction. We here identified a class of cerebrospinal…”
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A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4 super(+) T cells, including myeloid cells
Published in AIDS (London) (28-01-2014)“…We compared different techniques for measuring gut HIV reservoirs and assessed for HIV in non-CD4 super(+) T cells. HIV DNA levels were similar when measured…”
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Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration
Published in The Journal of clinical investigation (01-09-2012)“…Progress in neurodegenerative disease research is hampered by the lack of biomarkers of neuronal dysfunction. We here identified a class of cerebrospinal…”
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Journal Article -
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Site-Specific Differences in T Cell Frequencies and Phenotypes in the Blood and Gut of HIV-Uninfected and ART-Treated HIV+ Adults: e0121290
Published in PloS one (01-03-2015)“…Gastrointestinal T lymphocytes are critical for mucosal immunity and HIV pathogenesis, yet little is known about normal T cell numbers and phenotypes in…”
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