Search Results - "Killeen, Meaghan E"

Signaling through purinergic receptors for ATP induces human cutaneous innate and adaptive Th17 responses: implications in the pathogenesis of psoriasis by Killeen, Meaghan E, Ferris, Laura, Kupetsky, Erine A, Falo, Jr, Louis, Mathers, Alicia R

“…Human cutaneous dendritic cells (DCs) have the ability to prime and bias Th17 lymphocytes. However, the factors that stimulate cutaneous DCs to induce Th17…”
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Extracellular ATP and IL-23 Form a Local Inflammatory Circuit Leading to the Development of a Neutrophil-Dependent Psoriasiform Dermatitis by Diaz-Perez, Julio A., Killeen, Meaghan E., Yang, Yin, Carey, Cara D., Falo, Louis D., Mathers, Alicia R.

“…Psoriasis is a chronic inflammatory skin disease dependent on the IL-23/IL-17 axis, a potent inflammatory pathway involved in pathogen clearance and…”
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Electrophilic nitro-fatty acids suppress psoriasiform dermatitis: STAT3 inhibition as a contributory mechanism by Wang, Peng, Killeen, Meaghan E., Sumpter, Tina L., Ferris, Laura K., Falo, Louis D., Freeman, Bruce A., Schopfer, Francisco J., Mathers, Alicia R.

“…Psoriasis is a chronic inflammatory skin disease with no cure. Although the origin of psoriasis and its underlying pathophysiology remain incompletely…”
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HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers by Liu, Shiguang, Stolz, Donna B, Sappington, Penny L, Macias, Carlos A, Killeen, Meaghan E, Tenhunen, Jyrki J, Delude, Russell L, Fink, Mitchell P

“…High-mobility group box 1 (HMGB1), a cytokine-like proinflammatory protein, is secreted by activated macrophages and released by necrotic cells. We…”
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Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia by Yang, Runkuan, Miki, Keita, Oksala, Niku, Nakao, Atsunori, Lindgren, Leena, Killeen, Meaghan E, Mennander, Ari, Fink, Mitchell P, Tenhunen, Jyrki

“…Lipopolysaccharide (LPS) is an important factor in sepsis. LPS given by intraperitoneal injection induces intestinal hyperpermeability and bacterial…”
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The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells by Killeen, Meaghan E, Englert, Joshua A, Stolz, Donna Beer, Song, Mingchen, Han, Yusheng, Delude, Russell L, Kellum, John A, Fink, Mitchell P

“…The diuretic ethacrynic acid (EA) has been shown to inhibit signaling by the proinflammatory transcription factor nuclear factor-kappaB (NF-kappaB)…”
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Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity by Yang, Runkuan, Miki, Keita, He, Xin, Killeen, Meaghan E, Fink, Mitchell P

“…Acetaminophen (APAP) toxicity is the most common cause of acute liver failure in the US and Europe. Massive hepatocyte necrosis is the predominant feature of…”
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Topical electrophilic nitro-fatty acids potentiate cutaneous inflammation by Mathers, Alicia R., Carey, Cara D., Killeen, Meaghan E., Salvatore, Sonia R., Ferris, Laura K., Freeman, Bruce A., Schopfer, Francisco J., Falo, Louis D.

“…Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression…”
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mTORC2 deficiency in cutaneous dendritic cells potentiates CD8+ effector T cell responses and accelerates skin graft rejection by Watson, Alicia R., Dai, Helong, Diaz‐Perez, Julio A., Killeen, Meaghan E., Mathers, Alicia R., Thomson, Angus W.

“…Mechanistic target of rapamycin (mTOR) complex (mTORC)1 and mTORC2 regulate the differentiation and function of immune cells. While inhibition of mTORC1…”
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mTORC2 deficiency in cutaneous dendritic cells potentiates CD8+ effector T cell responses and accelerates skin graft rejection by Watson, Alicia R., Dai, Helong, Diaz-Perez, Julio A., Killeen, Meaghan E., Mathers, Alicia R., Thomson, Angus W.

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Ethyl Pyruvate Ameliorates Liver Injury Secondary to Severe Acute Pancreatitis by Yang, Runkuan, M.D., Ph.D, Shaufl, Angel L, Killeen, Meaghan E, Fink, Mitchell P., M.D

“…Background Ethyl pyruvate (EP) is capable of significantly decreasing serum alanine aminotransferase and reducing hepatic necrosis in a murine model of severe…”
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Extracellular activation of arginase-1 decreases enterocyte inducible nitric oxide synthase activity during systemic inflammation by Miki, Keita, Kumar, Abhai, Yang, Runkuan, Killeen, Meaghan E, Delude, Russell L

“…Liver dysfunction secondary to severe inflammation is associated with the release of enzymes normally sequestered within hepatocytes. The purpose of these…”
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The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro by Sappington, Penny L., Cruz, Ruy J., Harada, Tomoyuki, Yang, Runkuan, Han, Yusheng, Englert, Joshua A., Ajami, Alfred A., Killeen, Meaghan E., Delude, Russell L., Fink, Mitchell P.

“…Ethyl pyruvate (EP) is a simple aliphatic ester derived from the endogenous metabolite, pyruvic acid. EP has been shown to decrease the expression of various…”
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The respective contributions of P2X7 receptor variants to the development of psoriasiform dermatitis by Yang, Yin, Killeen, Meaghan E., Diaz-Perez, Julio A., Mathers, Alicia R.

“…Psoriasis is a chronic inflammatory cutaneous disease caused by environmental triggers in genetically predisposed individuals which account for 2–3% of the…”
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Glycolytic Bias in mTORC2 Deficient Dendritic Cells Potentiates Antigen-Specific Immunity and Accelerates Graft Rejection by Watson, Alicia, Dai, Helong, Diaz-Perez, Julio A, Menk, Ashley V, Killeen, Meaghan E, Delgoffe, Greg M, Mathers, Alicia R, Thomson, Angus W

“…BACKGROUND/HYPOTHESISThe mechanistic target of rapamycin (mTOR) is known to function in two discrete complexesmTOR complex 1 (mTORC1) and mTORC2. The function…”
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Electrophilic nitro‐fatty acids suppress allergic contact dermatitis in mice by Mathers, A. R., Carey, C. D., Killeen, M. E., Diaz‐Perez, J. A., Salvatore, S. R., Schopfer, F. J., Freeman, B. A., Falo, L. D.

“…Background Reactions between nitric oxide (NO), nitrite (NO2−), and unsaturated fatty acids give rise to electrophilic nitro‐fatty acids (NO2‐FAs), such as…”
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A NOVEL HEMIGRAMICIDIN-TEMPO CONJUGATE HAS ANTI-INFLAMMATORY EFFECTS IN VITRO AND IN VIVO: 30 by Macias, Carlos A, Killeen, Meaghan E, Singh, Devinder, Delude, Russell L, Fink, Mitchell P, Wipf, Peter

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PHOSPHATIDYLINOSITOL 3-KINASE AND CALCIUM-ACTI-VATED SIGNALING PATHWAYS ARE REQUIRED FOR HIGH MOBILITY GROUP B PROTEIN 1 RELEASE BY LPS-STIMULATED RAW 246.7 MURINE MACROPHAGE-LIKE CELLS: 138-T by Han, Yusheng, Liu, Shiguang, Delude, Russell L, Aneja, Rajesh, Killeen, Meaghan E, Fink, Mitchell P, Stolz, Donna B

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A NOVEL HEMIGRAMICIDIN-TEMPO CONJUGATE HAS ANTI-INFLAMMATORY EFFECTS IN VITRO AND IN VIVO.: 30 by Macias, Carlos A, Killeen, Meaghan E, Singh, Devinder, Delude, Russell L, Fink, Mitchell P, Wipf, Peter

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