Search Results - "Kilian, P L"

Visualization and characterization of interleukin 1 receptors in brain by Farrar, WL, Kilian, PL, Ruff, MR, Hill, JM, Pert, CB

“…Interleukin 1 (IL 1) is a polypeptide hormone produced by macrophages, keratinocytes, and brain glial cells which acts as a soluble mediator in immunological…”
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Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody by MCINTYRE, K. W, STEPAN, G. J, KOLINSKY, K. D, BENJAMIN, W. R, PLOCINSKI, J. M, KAFFKA, K. L, CAMPEN, C. A, CHIZZONITE, R. A, KILIAN, P. L

“…Recombinant human interleukin 1 receptor antagonist (IL-1ra) and 35F5, a neutralizing monoclonal antibody (mAb) to the type I mouse IL-1 receptor, were…”
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Interleukin 1 Receptor Blockade Attenuates the Host Inflammatory Response by Gershenwald, Jeffrey E., Fong, Yuman, Fahey, Thomas J., Calvano, Steve E., Chizzonite, Richard, Kilian, Patricia L., Lowry, Stephen F., Moldawer, Lyle L.

“…Cytokines, including interleukin 1 (IL-1), tumor necrosis factor α, and interleukin 6, are often produced in response to tissue injury and contribute to…”
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Type I IL-1 receptor blockade exacerbates murine listeriosis by Havell, EA, Moldawer, LL, Helfgott, D, Kilian, PL, Sehgal, PB

“…It was found that IL-1 is produced in livers and spleens of mice shortly after the i.v. injection of a sublethal or lethal Listeria monocytogenes inoculum. In…”
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A Mouse Model for Investigating the Molecular Pathogenesis of Adenovirus Pneumonia by Ginsberg, Harold S., Moldawer, Lyle L., Sehgal, Pravinkumar B., Redington, Miriam, Kilian, Patricia L., Chanock, Robert M., Prince, Gregory A.

“…Intranasal inoculation of type 5 adenovirus (Ad5) produced pneumonia in mice even though the virus did not replicate. To induce the pneumonia, however, a large…”
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Two High-Affinity Interleukin 1 Receptors Represent Separate Gene Products by Chizzonite, Richard, Truitt, Terri, Kilian, Patricia L., Stern, Alvin S., Nunes, Perla, Parker, Kathryn P., Kaffka, Kimberlee L., Chua, Anne O., Lugg, David K., Gubler, Ueli

“…Interleukin 1 (IL-1) is a polypeptide hormone that mediates a broad range of biological activities and interacts with surface receptors on numerous cell types…”
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Identification of the Discontinuous Binding Site in Human Interleukin 1β for the Type I Interleukin 1 Receptor by LABRIOLA-TOMPKINS, E, CHANDRAN, C, KAFFKA, K. L, BIODIN, D, GRAVES, B. J, HATADA, M, MADISON, V. S, KARAS, J, KILIAN, P. L, JU, G

“…Human interleukin 1β (IL-1β) exerts its diverse biological effects by binding to specific receptors on target cells. Two types of IL-1 receptor (IL-1R) have…”
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Interleukin 1 alpha and interleukin 1 beta bind to the same receptor on T cells by Kilian, PL, Kaffka, KL, Stern, AS, Woehle, D, Benjamin, WR, Dechiara, TM, Gubler, U, Farrar, JJ, Mizel, SB, Lomedico, PT

“…Pure, E. coli-derived recombinant murine interleukin 1 alpha (IL 1 alpha) was labeled with 125I and used for receptor binding studies. The 125I-IL 1 binds to…”
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The interleukin 1 receptor. Dynamics of interleukin 1 binding and internalization in T cells and fibroblasts by Mizel, SB, Kilian, PL, Lewis, JC, Paganelli, KA, Chizzonite, RA

“…In this study, we have demonstrated that a murine T cell lymphoma, EL 4, and a murine fibroblast cell line, Swiss 3T3, possess a single class of high affinity…”
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Conversion of the Interleukin 1 Receptor Antagonist into an Agonist by Site-Specific Mutagenesis by Ju, G., Labriola-Tompkins, E., Campen, C. A., Benjamin, W. R., Karas, J., Plocinski, J., Biondi, D., Kaffka, K. L., Kilian, P. L., Eisenberg, S. P., Evans, R. J.

“…Interleukin 1 (IL-1) receptor antagonist (IL-1ra) is a naturally occurring protein that binds to the IL-1 receptor present on T cells, fibroblasts, and other…”
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Interleukin-1 (IL-1) regulation of human endometrial function: presence of IL-1 receptor correlates with IL-1-stimulated prostaglandin E2 production by Tabibzadeh, S, Kaffka, K L, Satyaswaroop, P G, Kilian, P L

“…Previous studies suggest that prostaglandin E2 (PGE2) is important in normal endometrial function and that it may be involved in certain uterine dysfunctions…”
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Structure-function analysis of human interleukin-2. Identification of amino acid residues required for biological activity by Ju, G., Collins, L., Kaffka, K.L., Tsien, W.H., Chizzonite, R., Crowl, R., Bhatt, R., Kilian, P.L.

“…To locate functional domains of the interleukin-2 (IL-2) protein, a cDNA clone encoding biologically active human IL-2 was mutagenized using synthetic…”
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Presence of IL-1 receptors on human and murine neutrophils. Relevance to IL-1-mediated effects in inflammation by Parker, KP, Benjamin, WR, Kaffka, KL, Kilian, PL

“…Inflammatory responses are characterized by the infiltration of polymorphonuclear neutrophils (PMN) at the involved site. IL-1 may have an important role in…”
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Induction of fibrinogen and a subset of acute phase response genes involves a novel monokine which is mimicked by phorbol esters by Evans, E, Courtois, G M, Kilian, P L, Fuller, G M, Crabtree, G R

“…We have investigated the requirements for the induction of the acute phase response to inflammation using the FAZA rat hepatocyte cell line which can be…”
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Antiproliferative effect of interleukin-1 on human ovarian carcinoma cell line (NIH:OVCAR-3) by KILIAN, P. L, KAFFKA, K. L, BIONDI, D. A, LIPMAN, J. M, BENJAMIN, W. R, FELDMAN, D, CAMPEN, C. A

“…The human ovarian carcinoma cell line, NIH:OVCAR-3, possesses high affinity receptors for interleukin-1 (IL-1). Binding experiments with 125I-IL-1 alpha…”
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Detergent solubilization of the interleukin 1 receptor by Paganelli, KA, Stern, AS, Kilian, PL

“…Interleukin 1 (IL 1) receptors were solubilized from membranes prepared from murine EL-4 thymoma cells with the zwitterionic detergent 3[(3-cholamidopropyl)…”
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Structure-Function Analysis of Murine Interleukin 1: Biologically Active Polypeptides are at Least 127 Amino Acids Long and are Derived from the Carboxyl Terminus of a 270-Amino Acid Precursor by DeChiara, Thomas M., Young, Daru, Semionow, Raina, Stern, Alvin S., Batula-Bernardo, Cheryl, Fiedler-Nagy, Christa, Kaffka, Kimberlee L., Kilian, Patricia L., Yamazaki, Shigeko, Mizel, Steven B., Lomedico, Peter T.

“…Murine interleukin 1 (IL-1) is initially synthesized as a 270-amino acid precursor protein. Guided by amino-terminal end sequence analyses of mouse…”
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Induction and Upregulation by Interleukin 2 of High-Affinity Interleukin 2 Receptors on Thymocytes and T Cells by Reem, Gabrielle H., Yeh, Ning-Hsing, Urdal, David L., Kilian, Patricia L., Farrar, John J.

“…We show that purified recombinant interleukin 2 (rIL-2) alone induces the expression of high- and low-affinity interleukin 2 (IL-2) receptors in vitro on human…”
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Regulation of Expression of the Interleukin-2 Receptor on Hematopoietic Cells by Interleukin-3 by Birchenall-Sparks, Maria C., Farrar, William L., Rennick, Donna, Kilian, Patricia L., Ruscetti, Francis W.

“…Remarkable similarities in the intracellular and genetic events occur when lymphoid and hematopoietic cells are exposed to their specific growth factors. The…”
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Human Endometrial Epithelial Cell Lines for Studying Steroid and Cytokine Actions by S. Tabibzadeh, Kaffka, K. L., Kilian, P. L., Satyaswaroop, P. G.

“…Recent studies suggest that the proliferation and expression of HLA-DR molecules in endometrial epithelium may be regulated by systemic steroids and local…”
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