Search Results - "Kilgour, Elaine"

Molecular Pathways: Fibroblast Growth Factor Signaling: A New Therapeutic Opportunity in Cancer by BROOKS, A. Nigel, KILGOUR, Elaine, SMITH, Paul D

“…The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays an important role in normal organ, vascular, and skeletal…”
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AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family by GAVINE, Paul R, MOONEY, Lorraine, NIGEL BROOKS, A, KLINOWSKA, Teresa, KILGOUR, Elaine, THOMAS, Andrew P, AL-KADHIMI, Katherine, BECK, Sarah, ROONEY, Claire, COLEMAN, Tanya, BAKER, Dawn, MELLOR, Martine J

“…The fibroblast growth factor (FGF) signaling axis is increasingly implicated in tumorigenesis and chemoresistance. Several small-molecule FGF receptor (FGFR)…”
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FGFR2 Gene Amplification in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD4547 by LIANG XIE, XINYING SU, BEIRONG GAO, DANPING SHEN, LIANHAI ZHANG, JIAFU JI, GAVINE, Paul R, JINGCHUAN ZHANG, KILGOUR, Elaine, XIAOLIN ZHANG, QUNSHENG JI, LIN ZHANG, XIAOLU YIN, LILI TANG, XIUHUA ZHANG, YANPING XU, ZEREN GAO, KUNJI LIU, MINHUA ZHOU

“…FGFR gene aberrations are associated with tumor growth and survival. We explored the role of FGFR2 amplification in gastric cancer and the therapeutic…”
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High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial by Pearson, Alex, Smyth, Elizabeth, Babina, Irina S, Herrera-Abreu, Maria Teresa, Tarazona, Noelia, Peckitt, Clare, Kilgour, Elaine, Smith, Neil R, Geh, Catherine, Rooney, Claire, Cutts, Ros, Campbell, James, Ning, Jian, Fenwick, Kerry, Swain, Amanda, Brown, Gina, Chua, Sue, Thomas, Anne, Johnston, Stephen R D, Ajaz, Mazhar, Sumpter, Katherine, Gillbanks, Angela, Watkins, David, Chau, Ian, Popat, Sanjay, Cunningham, David, Turner, Nicholas C

“…FGFR1 and FGFR2 are amplified in many tumor types, yet what determines response to FGFR inhibition in amplified cancers is unknown. In a translational clinical…”
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Translating the Therapeutic Potential of AZD4547 in FGFR1-Amplified Non―Small Cell Lung Cancer through the Use of Patient-Derived Tumor Xenograft Models by JINGCHUAN ZHANG, LIN ZHANG, ZHENGWEI DONG, GUANSHAN ZHU, ZILIANG QIAN, LILI TANG, PING ZHAN, QUNSHENG JI, KILGOUR, Elaine, SMITH, Paul D, NIGEL BROOKS, A, THOMAS, Roman K, XINYING SU, GAVINE, Paul R, MING LI, LIANG XIE, MALCHERS, Florian, SHUQIONG FAN, XIAOLU YIN, YANPING XU, KUNJI LIU

“…To investigate the incidence of FGFR1 amplification in Chinese non-small cell lung cancer (NSCLC) and to preclinically test the hypothesis that the novel,…”
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Serial monitoring of genomic alterations in circulating tumor cells of ER‐positive/HER2‐negative advanced breast cancer: feasibility of precision oncology biomarker detection by Cani, Andi K., Dolce, Emily M., Darga, Elizabeth P., Hu, Kevin, Liu, Chia‐Jen, Pierce, Jackie, Bradbury, Kieran, Kilgour, Elaine, Aung, Kimberly, Schiavon, Gaia, Carroll, Danielle, Carr, T. Hedley, Klinowska, Teresa, Lindemann, Justin, Marshall, Gayle, Rowlands, Vicky, Harrington, Elizabeth A., Barrett, J. Carl, Sathiyayogan, Nitharsan, Morrow, Christopher, Sero, Valeria, Armstrong, Anne C., Baird, Richard, Hamilton, Erika, Im, Seock‐Ah, Jhaveri, Komal, Patel, Manish R., Dive, Caroline, Tomlins, Scott A., Udager, Aaron M., Hayes, Daniel F., Paoletti, Costanza

“…Nearly all estrogen receptor (ER)‐positive (POS) metastatic breast cancers become refractory to endocrine (ET) and other therapies, leading to lethal disease…”
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Characterization of FGFR1 Locus in sqNSCLC Reveals a Broad and Heterogeneous Amplicon by Rooney, Claire, Geh, Catherine, Williams, Victoria, Heuckmann, Johannes M, Menon, Roopika, Schneider, Petra, Al-Kadhimi, Katherine, Dymond, Michael, Smith, Neil R, Baker, Dawn, French, Tim, Smith, Paul D, Harrington, Elizabeth A, Barrett, J Carl, Kilgour, Elaine

“…FGFR1 amplification occurs in ~20% of sqNSCLC and trials with FGFR inhibitors have selected FGFR1 amplified patients by FISH. Lung cancer cell lines were…”
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Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor by Vincent, Emma E, Elder, Douglas J E, Curwen, Jon, Kilgour, Elaine, Hers, Ingeborg, Tavaré, Jeremy M

“…Phase III trials of the anti-insulin-like growth factor-1 receptor (IGF1R) antibody figitumumab in non-small cell lung cancer (NSCLC) patients have been…”
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Liquid Biopsy-Based Biomarkers of Treatment Response and Resistance by Kilgour, Elaine, Rothwell, Dominic G., Brady, Ged, Dive, Caroline

“…Predictive biomarkers aid selection of personalized therapy targeted to molecular alterations within an individual's tumor. Patients' responses to targeted…”
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Molecular characterisation and liquid biomarkers in Carcinoma of Unknown Primary (CUP): taking the ‘U’ out of ‘CUP’ by Conway, Alicia-Marie, Mitchell, Claire, Kilgour, Elaine, Brady, Gerard, Dive, Caroline, Cook, Natalie

“…Cancers of Unknown Primary (CUP) comprise a heterogeneous clinical entity of confirmed metastatic cancer where the primary site of origin is undetectable. It…”
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Will liquid biopsies improve outcomes for patients with small-cell lung cancer? by Blackhall, Fiona, Frese, Kristopher K, Simpson, Kathryn, Kilgour, Elaine, Brady, Ged, Dive, Caroline

“…Small-cell lung cancer (SCLC) is an aggressive tumour that seeds metastases early with dismal outcomes. As expected from a disease that is closely associated…”
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Selumetinib Plus Docetaxel Compared With Docetaxel Alone and Progression-Free Survival in Patients With KRAS-Mutant Advanced Non–Small Cell Lung Cancer: The SELECT-1 Randomized Clinical Trial by Jänne, Pasi A, van den Heuvel, Michel M, Barlesi, Fabrice, Cobo, Manuel, Mazieres, Julien, Crinò, Lucio, Orlov, Sergey, Blackhall, Fiona, Wolf, Juergen, Garrido, Pilar, Poltoratskiy, Artem, Mariani, Gabriella, Ghiorghiu, Dana, Kilgour, Elaine, Smith, Paul, Kohlmann, Alexander, Carlile, David J, Lawrence, David, Bowen, Karin, Vansteenkiste, Johan

“…IMPORTANCE: There are no specifically approved targeted therapies for the most common genomically defined subset of non–small cell lung cancer (NSCLC),…”
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Growth Hormone-dependent Differentiation of 3T3-F442A Preadipocytes Requires Janus Kinase/Signal Transducer and Activator of Transcription but Not Mitogen-activated Protein Kinase or p70 S6 Kinase Signaling by Yarwood, S J, Sale, E M, Sale, G J, Houslay, M D, Kilgour, E, Anderson, N G

“…The signals mediating growth hormone (GH)-dependent differentiation of 3T3-F442A preadipocytes under serum-free conditions have been studied. GH priming of…”
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Geospatial immune variability illuminates differential evolution of lung adenocarcinoma by AbdulJabbar, Khalid, Raza, Shan E. Ahmed, Rosenthal, Rachel, Jamal-Hanjani, Mariam, Veeriah, Selvaraju, Akarca, Ayse, Lund, Tom, Moore, David A., Salgado, Roberto, Al Bakir, Maise, Zapata, Luis, Hiley, Crispin T., Officer, Leah, Sereno, Marco, Smith, Claire Rachel, Loi, Sherene, Hackshaw, Allan, Marafioti, Teresa, Quezada, Sergio A., McGranahan, Nicholas, Le Quesne, John, Swanton, Charles, Yuan, Yinyin

“…Remarkable progress in molecular analyses has improved our understanding of the evolution of cancer cells toward immune escape 1 – 5 . However, the spatial…”
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Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT) by Carvajal, Richard D, Piperno-Neumann, Sophie, Kapiteijn, Ellen, Chapman, Paul B, Frank, Stephen, Joshua, Anthony M, Piulats, Josep M, Wolter, Pascal, Cocquyt, Veronique, Chmielowski, Bartosz, Evans, T R Jeffry, Gastaud, Lauris, Linette, Gerald, Berking, Carola, Schachter, Jacob, Rodrigues, Manuel J, Shoushtari, Alexander N, Clemett, Delyth, Ghiorghiu, Dana, Mariani, Gabriella, Spratt, Shirley, Lovick, Susan, Barker, Peter, Kilgour, Elaine, Lai, Zhongwu, Schwartz, Gary K, Nathan, Paul

“…Purpose Uveal melanoma is the most common primary intraocular malignancy in adults with no effective systemic treatment option in the metastatic setting…”
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Antibodies against endogenous retroviruses promote lung cancer immunotherapy by Ng, Kevin W., Boumelha, Jesse, Enfield, Katey S. S., Almagro, Jorge, Cha, Hongui, Pich, Oriol, Karasaki, Takahiro, Moore, David A., Salgado, Roberto, Sivakumar, Monica, Young, George, Molina-Arcas, Miriam, de Carné Trécesson, Sophie, Anastasiou, Panayiotis, Fendler, Annika, Au, Lewis, Shepherd, Scott T. C., Martínez-Ruiz, Carlos, Puttick, Clare, Black, James R. M., Watkins, Thomas B. K., Kim, Hyemin, Shim, Seohee, Faulkner, Nikhil, Attig, Jan, Veeriah, Selvaraju, Magno, Neil, Ward, Sophia, Frankell, Alexander M., Al Bakir, Maise, Lim, Emilia L., Hill, Mark S., Wilson, Gareth A., Cook, Daniel E., Birkbak, Nicolai J., Behrens, Axel, Yousaf, Nadia, Popat, Sanjay, Hackshaw, Allan, Hiley, Crispin T., Litchfield, Kevin, McGranahan, Nicholas, Jamal-Hanjani, Mariam, Larkin, James, Lee, Se-Hoon, Turajlic, Samra, Swanton, Charles, Downward, Julian, Kassiotis, George

“…B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS) 1 , 2…”
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Abstract 601: Liquid biopsy-based precision medicine for extra-pulmonary neuroendocrine carcinomas by Frizziero, Melissa, Kilgour, Elaine, Simpson, Kathryn, Frese, Kristopher, Valle, Juan W., McNamara, Mairéad G., Dive, Caroline

“…Abstract Extra-Pulmonary NeuroEndocrine Carcinomas (EP-NECs) are aggressive tumours (Ki-67>20%, poorly differentiated morphology), with a median overall…”
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Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse by Chemi, Francesca, Rothwell, Dominic G., McGranahan, Nicholas, Gulati, Sakshi, Abbosh, Chris, Pearce, Simon P., Zhou, Cong, Wilson, Gareth A., Jamal-Hanjani, Mariam, Birkbak, Nicolai, Pierce, Jackie, Kim, Chang Sik, Ferdous, Saba, Burt, Deborah J., Slane-Tan, Daniel, Gomes, Fabio, Moore, David, Shah, Rajesh, Al Bakir, Maise, Hiley, Crispin, Veeriah, Selvaraju, Summers, Yvonne, Crosbie, Philip, Ward, Sophia, Mesquita, Barbara, Dynowski, Marek, Biswas, Dhruva, Tugwood, Jonathan, Blackhall, Fiona, Miller, Crispin, Hackshaw, Allan, Brady, Ged, Swanton, Charles, Dive, Caroline

“…Approximately 50% of patients with early-stage non-small-cell lung cancer (NSCLC) who undergo surgery with curative intent will relapse within 5 years 1 , 2 …”
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A Phase Ib Open-Label Multicenter Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers by Paik, Paul K, Shen, Ronglai, Berger, Michael F, Ferry, David, Soria, Jean-Charles, Mathewson, Alastair, Rooney, Claire, Smith, Neil R, Cullberg, Marie, Kilgour, Elaine, Landers, Donal, Frewer, Paul, Brooks, Nigel, André, Fabrice

“…Squamous cell lung cancers (SQCLC) account for 25% of all NSCLCs, yet the prognosis of these patients is poor and treatment options are limited. Amplified is…”
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Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation by Fleming, I, MacKenzie, S J, Vernon, R G, Anderson, N G, Houslay, M D, Kilgour, E

“…In this study we first established, by immunoblotting with specific antibodies, the temporal changes in cellular levels of protein kinase C (PKC) isoforms…”
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