Search Results - "Kilgour, David P. A."

Rapid Denaturing Organic Digestion Method for Targeted Protein Identification and Characterization by Oyler, Jonathan M, Tran, Bao Q, Kilgour, David P. A

“…Bottom-up mass spectrometry-based protein analysis methods employing protease digestion are routinely used to identify and characterize proteins with high…”
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Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry by van der Burgt, Yuri E.M, Kilgour, David P. A, Tsybin, Yury O, Srzentić, Kristina, Fornelli, Luca, Beck, Alain, Wuhrer, Manfred, Nicolardi, Simone

“…The emergence of complex protein therapeutics in general and monoclonal antibodies (mAbs) in particular have stimulated analytical chemists to develop new…”
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Evaluation of Sibling and Twin Fragment Ions Improves the Structural Characterization of Proteins by Top-Down MALDI In‑Source Decay Mass Spectrometry by Nicolardi, Simone, Kilgour, David P. A, Dolezal, Natasja, Drijfhout, Jan W, Wuhrer, Manfred, van der Burgt, Yuri E. M

“…Comprehensive determination of primary sequence and identification of post-translational modifications (PTMs) are key elements in protein structural analysis…”
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Absorption-Mode Fourier Transform Mass Spectrometry: The Effects of Apodization and Phasing on Modified Protein Spectra by Qi, Yulin, Li, Huilin, Wills, Rebecca H., Perez-Hurtado, Pilar, Yu, Xiang, Kilgour, David P. A., Barrow, Mark P., Lin, Cheng, O’Connor, Peter B.

“…The method of phasing broadband Fourier transform ion cyclotron resonance (FT-ICR) spectra allows plotting the spectra in the absorption-mode; this new…”
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Improved optimization of the Fourier transform ion cyclotron resonance mass spectrometry phase correction function using a genetic algorithm by Kilgour, David P. A., Neal, Mark J., Soulby, Andrew J., O'Connor, Peter B.

“…RATIONALE Fourier Transform Ion Cyclotron Resonance mass spectra exhibit improved resolving power, mass accuracy and signal‐to‐noise ratio when presented in…”
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Increased throughput and ultra-high mass resolution in DESI FT-ICR MS imaging through new-generation external data acquisition system and advanced data processing approaches by Kooijman, Pieter C., Nagornov, Konstantin O., Kozhinov, Anton N., Kilgour, David P. A., Tsybin, Yury O., Heeren, Ron M. A., Ellis, Shane R.

“…Desorption electrospray ionisation-mass spectrometry imaging (DESI-MSI) is a powerful imaging technique for the analysis of complex surfaces. However, the…”
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Native-MS Analysis of Monoclonal Antibody Conjugates by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by Campuzano, Iain D. G, Netirojjanakul, Chawita, Nshanian, Michael, Lippens, Jennifer L, Kilgour, David P. A, Van Orden, Steve, Loo, Joseph A

“…Antibody-drug conjugates (ADCs) are an important class of therapeutic molecule currently being used to treat HER2-positive metastatic breast cancer, relapsed…”
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Autophaser: An Algorithm for Automated Generation of Absorption Mode Spectra for FT-ICR MS by Kilgour, David P. A, Wills, Rebecca, Qi, Yulin, O’Connor, Peter B

“…Phase correction of Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry data allows the spectra to be presented in absorption mode. Absorption…”
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Isotope Depletion Mass Spectrometry (ID-MS) for Accurate Mass Determination and Improved Top-Down Sequence Coverage of Intact Proteins by Gallagher, Kelly J, Palasser, Michael, Hughes, Sam, Mackay, C. Logan, Kilgour, David P. A, Clarke, David J

“…Top-down mass spectrometry (MS) is an increasingly important technique for protein characterization. However, in many biological MS experiments, the…”
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The present and potential future of aqueous mercury preservation: a review by King, David C P, Watts, Michael J, Hamilton, Elliott M, Mortimer, Robert, Kilgour, David P A, Di Bonito, Marcello

“…Mercury is considered to be one of the most toxic elements to humans. Due to pollution from industry and artisanal gold mining, mercury species are present…”
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Improved N- and C‑Terminal Sequencing of Proteins by Combining Positive and Negative Ion MALDI In-Source Decay Mass Spectrometry by Nicolardi, Simone, Kilgour, David P. A, van der Burgt, Yuri E. M, Wuhrer, Manfred

“…The development of various ionization and fragmentation techniques has been of key importance for establishing mass spectrometry (MS) as a powerful tool for…”
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Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry by Gstöttner, Christoph, Reusch, Dietmar, Haberger, Markus, Dragan, Irina, Van Veelen, Peter, Kilgour, David P A, Tsybin, Yury O, van der Burgt, Yuri E M, Wuhrer, Manfred, Nicolardi, Simone

“…Bispecific monoclonal antibodies (BsAbs) are engineered proteins with multiple functionalities and properties. The "bi-specificity" of these complex…”
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Perspectives on the future of mass spectrometry by Trevorrow, Paul, Kilgour, David P.A.

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Absorption mode Fourier transform mass spectrometry with no baseline correction using a novel asymmetric apodization function by Kilgour, David P. A., Van Orden, Steven L.

“…Rationale Absorption mode Fourier transform ion cyclotron resonance (FTICR) mass spectra offer significant benefits in terms of spectral resolution,…”
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Producing Isotopic Distribution Models for Fully Apodized Absorption Mode FT-MS by Kilgour, David P. A, Van Orden, Steven L, Tran, Bao Quoc, Goo, Young Ah, Goodlett, David R

“…Isotopic distributions are frequently used as part of the peak assignment process in the processing of mass spectra. The best methods for producing accurate…”
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Absorption Mode FTICR Mass Spectrometry Imaging by Smith, Donald F, Kilgour, David P. A, Konijnenburg, Marco, O’Connor, Peter B, Heeren, Ron M. A

“…Fourier transform ion cyclotron resonance mass spectrometry offers the highest mass resolving power for molecular imaging experiments. This high mass resolving…”
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Producing absorption mode Fourier transform ion cyclotron resonance mass spectra with non-quadratic phase correction functions by Kilgour, David P. A., Nagornov, Konstantin O., Kozhinov, Anton N., Zhurov, Konstantin O., Tsybin, Yury O.

“…Rationale Previously described methods for producing absorption mode Fourier transform ion cyclotron resonance (FTICR) mass spectra have all relied on the…”
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Surface acoustic wave nebulization device with dual interdigitated transducers improves SAWN-MS performance by Huang, Yue, Heron, Scott R., Clark, Alicia M., Edgar, J. Scott, Yoon, Sung Hwan, Kilgour, David P. A., Turecek, Frantisek, Aliseda, Alberto, Goodlett, David R.

“…We compared mass spectrometric (MS) performance of surface acoustic wave nebulization (SAWN) generated by a single interdigitated transducer (IDT) designed to…”
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Appropriate Degree of Trust: Deriving Confidence Metrics for Automatic Peak Assignment in High-Resolution Mass Spectrometry by Kilgour, David P. A, Mackay, C. Logan, Langridge-Smith, Patrick R. R, O’Connor, Peter B

“…Techniques for deriving confidence metrics for the reliability of automatically assigned elemental formulas in complex spectra, from high-resolution mass…”
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Use of an Artificial Immune System Derived Method for the Charge State Assignment of Small-Molecule Mass Spectra by Kilgour, David P. A, Mackay, C. Logan, Langridge-Smith, Patrick R. R, O’Connor, Peter B

“…Knowing the charge state of an ion in a mass spectrum is crucial to being able to assign a formula to it. For many small-molecule peaks in complex mass…”
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