Search Results - "Kiledjian, Megerditch"

Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA by Sharma, Sunny, Yang, Jun, Grudzien-Nogalska, Ewa, Shivas, Jessica, Kwan, Kelvin Y., Kiledjian, Megerditch

“…The existence of non-canonical nicotinamide adenine diphosphate (NAD) 5′-end capped RNAs is now well established. Nevertheless, the biological function of this…”
Get full text

SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer by Wang, Xiaowen, Zhang, Hong, Sapio, Russell, Yang, Jun, Wong, Justin, Zhang, Xin, Guo, Jessie Y., Pine, Sharon, Van Remmen, Holly, Li, Hong, White, Eileen, Liu, Chen, Kiledjian, Megerditch, Pestov, Dimitri G., Steven Zheng, X. F.

“…SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target. However, the role of SOD1 in cancer is not fully understood. Herein we…”
Get full text

Structural and mechanistic basis of mammalian Nudt12 RNA deNADding by Grudzien-Nogalska, Ewa, Wu, Yixuan, Jiao, Xinfu, Cui, Huijuan, Mateyak, Maria K., Hart, Ronald P., Tong, Liang, Kiledjian, Megerditch

“…We recently demonstrated that mammalian cells harbor nicotinamide adenine dinucleotide (NAD)-capped messenger RNAs that are hydrolyzed by the DXO deNADding…”
Get full text

The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA by Tan, Dazhi, Zhou, Mi, Kiledjian, Megerditch, Tong, Liang

“…Roquin recognizes the CDE element in mRNAs to promote their decay. Crystal structures of human Roquin ROQ domain in complex with RNA reveals two distinct…”
Get full text

5′ End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding by Jiao, Xinfu, Doamekpor, Selom K., Bird, Jeremy G., Nickels, Bryce E., Tong, Liang, Hart, Ronald P., Kiledjian, Megerditch

“…Eukaryotic mRNAs generally possess a 5′ end N7 methyl guanosine (m7G) cap that promotes their translation and stability. However, mammalian mRNAs can also…”
Get full text

A Mammalian Pre-mRNA 5′ End Capping Quality Control Mechanism and an Unexpected Link of Capping to Pre-mRNA Processing by Jiao, Xinfu, Chang, Jeong Ho, Kilic, Turgay, Tong, Liang, Kiledjian, Megerditch

“…Recently, we reported that two homologous yeast proteins, Rai1 and Dxo1, function in a quality control mechanism to clear cells of incompletely 5′ end-capped…”
Get full text

Multiple Nudix family proteins possess mRNA decapping activity by Song, Man-Gen, Bail, Sophie, Kiledjian, Megerditch

“…RNA decapping is an important contributor to gene expression and is a critical determinant of mRNA decay. The recent demonstration that mammalian cells harbor…”
Get full text

Highly efficient 5' capping of mitochondrial RNA with NAD + and NADH by yeast and human mitochondrial RNA polymerase by Bird, Jeremy G, Basu, Urmimala, Kuster, David, Ramachandran, Aparna, Grudzien-Nogalska, Ewa, Towheed, Atif, Wallace, Douglas C, Kiledjian, Megerditch, Temiakov, Dmitry, Patel, Smita S, Ebright, Richard H, Nickels, Bryce E

“…Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine…”
Get full text

Differential regulation of microRNA stability by Bail, Sophie, Swerdel, Mavis, Liu, Hudan, Jiao, Xinfu, Goff, Loyal A, Hart, Ronald P, Kiledjian, Megerditch

“…MicroRNAs (miRNAs) are endogenous single-stranded RNA molecules of about 21 nucleotides in length that are fundamental post-transcriptional regulators of gene…”
Get full text

Identification of a quality-control mechanism for mRNA 5′-end capping by Kiledjian, Megerditch, Jiao, Xinfu, Xiang, Song, Oh, ChanSeok, Martin, Charles E, Tong, Liang

“…The 7-methylguanosine cap structure at the 5′ end of eukaryotic messenger RNAs is a critical determinant of their stability and translational efficiency. It is…”
Get full text

3' Terminal oligo U-tract-mediated stimulation of decapping by Song, Man-Gen, Kiledjian, Megerditch

“…Decapping is a critical step in the control of gene expression and is regulated by both positive and negative trans factors. Less is known about cis elements…”
Get full text

Structure and function of the 5′→3′ exoribonuclease Rat1 and its activating partner Rai1 by Xiang, Song, Cooper-Morgan, Amalene, Jiao, Xinfu, Kiledjian, Megerditch, Manley, James L., Tong, Liang

“…Exoribonucleases in yeast Exoribonucleases are important processing enzymes in many aspects of RNA metabolism. The activity of yeast Rat1, a 5′–3′ exonuclease,…”
Get full text

NADcapPro and circNC: methods for accurate profiling of NAD and non-canonical RNA caps in eukaryotes by Sharma, Sunny, Yang, Jun, Favate, John, Shah, Premal, Kiledjian, Megerditch

“…Accurate identification of NAD-capped RNAs is essential for delineating their generation and biological function. Previous transcriptome-wide methods used to…”
Get full text

The DcpS inhibitor RG3039 improves survival, function and motor unit pathologies in two SMA mouse models by Gogliotti, Rocky G, Cardona, Herminio, Singh, Jasbir, Bail, Sophie, Emery, Carina, Kuntz, Nancy, Jorgensen, Michael, Durens, Madel, Xia, Bing, Barlow, Courtenay, Heier, Christopher R, Plasterer, Heather L, Jacques, Vincent, Kiledjian, Megerditch, Jarecki, Jill, Rusche, James, DiDonato, Christine J

“…Spinal muscular atrophy (SMA) is caused by insufficient levels of the survival motor neuron (SMN) protein due to the functional loss of the SMN1 gene and the…”
Get full text

Functional Link between the Mammalian Exosome and mRNA Decapping by Wang, Zuoren, Kiledjian, Megerditch

“…Mechanistic understanding of mammalian mRNA turnover remains incomplete. We demonstrate that the 3′ to 5′ exoribonuclease decay pathway is a major contributor…”
Get full text

Preparation of RNAs with non-canonical 5' ends using novel di- and trinucleotide reagents for co-transcriptional capping by Depaix, Anaïs, Grudzien-Nogalska, Ewa, Fedorczyk, Bartlomiej, Kiledjian, Megerditch, Jemielity, Jacek, Kowalska, Joanna

“…Many eukaryotic and some bacterial RNAs are modified at the 5' end by the addition of cap structures. In addition to the classic 7-methylguanosine 5' cap in…”
Get full text

Dcp2 Decapping Protein Modulates mRNA Stability of the Critical Interferon Regulatory Factor (IRF) IRF-7 by Li, You, Dai, Jihong, Song, Mangen, Fitzgerald-Bocarsly, Patricia, Kiledjian, Megerditch

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment by Ahmed, Iltaf, Buchert, Rebecca, Zhou, Mi, Jiao, Xinfu, Mittal, Kirti, Sheikh, Taimoor I, Scheller, Ute, Vasli, Nasim, Rafiq, Muhammad Arshad, Brohi, M Qasim, Mikhailov, Anna, Ayaz, Muhammad, Bhatti, Attya, Sticht, Heinrich, Nasr, Tanveer, Carter, Melissa T, Uebe, Steffen, Reis, André, Ayub, Muhammad, John, Peter, Kiledjian, Megerditch, Vincent, John B, Jamra, Rami Abou

“…There are two known mRNA degradation pathways, 3' to 5' and 5' to 3'. We identified likely pathogenic variants in two genes involved in these two pathways in…”
Get full text

Eukaryotic RNA 5′-End NAD+ Capping and DeNADding by Kiledjian, Megerditch

“…A hallmark of eukaryotic mRNAs has long been the 5′-end m7G cap. This paradigm was recently amended by recent reports that Saccharomyces cerevisiae and…”
Get full text

The hDcp2 Protein Is a Mammalian mRNA Decapping Enzyme by Wang, Zuoren, Jiao, Xinfu, Carr-Schmid, Anne, Kiledjian, Megerditch

“…Decapping of mRNA is a critical step in eukaryotic mRNA turnover, yet the proteins involved in this activity remain elusive in mammals. We identified the human…”
Get full text