Search Results - "Kilduff, T. S."

A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight by Revel, F G, Moreau, J-L, Pouzet, B, Mory, R, Bradaia, A, Buchy, D, Metzler, V, Chaboz, S, Groebke Zbinden, K, Galley, G, Norcross, R D, Tuerck, D, Bruns, A, Morairty, S R, Kilduff, T S, Wallace, T L, Risterucci, C, Wettstein, J G, Hoener, M C

“…Schizophrenia is a chronic, severe and highly complex mental illness. Current treatments manage the positive symptoms, yet have minimal effects on the negative…”
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The Hypocretins: Hypothalamus-Specific Peptides with Neuroexcitatory Activity by De Lecea, L., Kilduff, T. S., Peyron, C., X.-B. Gao, Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., Frankel, W. N., Van Den Pol, A. N., Bloom, F. E., Gautvik, K. M., Sutcliffe, J. G.

“…We describe a hypothalamus-specific mRNA that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid…”
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Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip® study by Terao, A., Wisor, J.P., Peyron, C., Apte-Deshpande, A., Wurts, S.W., Edgar, D.M., Kilduff, T.S.

“…Previous studies have demonstrated that macromolecular synthesis in the brain is modulated in association with the occurrence of sleep and wakefulness…”
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The hypocretin/orexin ligand–receptor system: implications for sleep and sleep disorders by Kilduff, Thomas S., Peyron, Christelle

“…The molecules originally described as the hypocretins and subsequently as the orexins were initially implicated in the control of food intake. Recent…”
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Further characterization of sleep-active neuronal nitric oxide synthase neurons in the mouse brain by Pasumarthi, R.K, Gerashchenko, D, Kilduff, T.S

“…Abstract We recently demonstrated that Fos is induced in a subpopulation of cortical neuronal nitric oxide synthase (nNOS)-immunoreactive neurons in three…”
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Region-specific changes in immediate early gene expression in response to sleep deprivation and recovery sleep in the mouse brain by Terao, A, Greco, M.A, Davis, R.W, Heller, H.C, Kilduff, T.S

“…Previous studies have documented changes in expression of the immediate early gene (IEG) c-fos and Fos protein in the brain between sleep and wakefulness. Such…”
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Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice by Tsunematsu, Tomomi, Kilduff, Thomas S, Boyden, Edward S, Takahashi, Satoru, Tominaga, Makoto, Yamanaka, Akihiro

“…Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. To help determine how these neurons promote wakefulness, we generated…”
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Differential increase in the expression of heat shock protein family members during sleep deprivation and during sleep by Terao, A., Steininger, T.L., Hyder, K., Apte-Deshpande, A., Ding, J., Rishipathak, D., Davis, R.W., Heller, H.C., Kilduff, T.S.

“…Although sleep is thought to be restorative from prior wakeful activities, it is not clear what is being restored. To determine whether the synthesis of…”
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Food- and light-entrained circadian rhythms in rats with hypocretin-2-saporin ablations of the lateral hypothalamus by Mistlberger, R.E, Antle, M.C, Kilduff, T.S, Jones, M

“…Daily feeding schedules can entrain circadian rhythms of food-anticipatory activity in mammals. The site of the circadian oscillators that drive food-entrained…”
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Gene expression in the rat brain during prostaglandin D₂ and adenosinergically-induced sleep by Terao, Akira, Huang, Zhi-Li, Wisor, Jonathan P, Mochizuki, Takatoshi, Gerashchenko, Dmitry, Urade, Yoshihiro, Kilduff, T.S

“…Previous studies have supported the hypothesis that macromolecular synthesis occurs in the brain during sleep as a response to prior waking activities and that…”
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Transcriptional regulation of the mouse fatty acid amide hydrolase gene by Waleh, N S, Cravatt, B F, Apte-Deshpande, A, Terao, A, Kilduff, T S

“…Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme that inactivates a family of fatty acid amide molecules which are implicated in physiological…”
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Gene expression in the rat cerebral cortex: Comparison of recovery sleep and hypnotic-induced sleep by Wisor, J.P., Morairty, S.R., Huynh, N.T., Steininger, T.L., Kilduff, T.S.

“…Most hypnotic medications currently on the market target some aspect of GABAergic neurotransmission. Although all such compounds increase sleep, these drugs…”
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Preprohypocretin (orexin) and prolactin-like immunoreactivity are coexpressed by neurons of the rat lateral hypothalamic area by Risold, P.Y, Griffond, B, Kilduff, T.S, Sutcliffe, J.G, Fellmann, D

“…Recently, two new neuropeptides named hypocretins I and II (Hcrt) have been described in the rat lateral hypothalamus. The distribution of the neurons…”
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0100 LATERAL HYPOTHALAMIC HYPOCRETIN AND NON-HYPOCRETIN NEURONS ACTIVATE PARALLEL AROUSAL PATHWAYS by Heiss, JE, Yamanaka, A, Kilduff, TS

“…Abstract Introduction: Until recently, hypocretin (HCRT) neurons were the only verified wake-promoting neurons in the lateral hypothalamus (LH). Lately,…”
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Sleepy dogs don't lie: a genetic disorder informative about sleep by Kilduff, T S

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Prepro-hypocretin (prepro-orexin) expression is unaffected by short-term sleep deprivation in rats and mice by TERAO, Akira, PEYRON, Christelle, DING, Jane, WURTS, Sarah W, EDGAR, Dale M, HELLER, H. Craig, KILDUFF, Thomas S

“…The hypocretin/orexin ligand-receptor system has recently been implicated in the sleep disorder narcolepsy. During the dark (active) period, null mutants of…”
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0122 HYPOCRETIN AFFECTS THE EXCITABILITY OF CORTICAL NNOS/NK1 NEURONS by Williams, RH, Black, SW, Thomas, AM, Piquet, J, Cauli, B, Kilduff, TS

“…Abstract Introduction: Cortical neuronal nitric oxide synthase (nNOS) neurons, identified by co-expression of the neurokinin-1 (NK1) receptor, are thought to…”
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0014 TRACE AMINE-ASSOCIATED RECEPTOR 1 REGULATES WAKEFULNESS, BEHAVIORAL ACTIVATION AND EEG SPECTRAL COMPOSITION by Schwartz, MD, Black, SW, Morairty, SR, Hoener, MC, Kilduff, TS

“…Abstract Introduction: Trace amines (TAs) are endogenous amino acid metabolites that are structurally similar to the biogenic amines. TAs are endogenous…”
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Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems by Peyron, Christelle, Tighe, Devin K, van den Pol, Anthony N, de Lecea, Luis, Heller, H. Craig, Sutcliffe, J. Gregor, Kilduff, Thomas S

“…The novel neuropeptides called hypocretins (orexins) have recently been identified as being localized exclusively in cell bodies in a subregion of the tuberal…”
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Modulation of the promoter region of prepro-hypocretin by alpha-interferon by Waleh, N S, Apte-Deshpande, A, Terao, A, Ding, J, Kilduff, T S

“…Hypocretins 1 and 2 (also called orexins A and B, respectively) are hypothalamic neuropeptides that have recently been shown to be involved in the sleep…”
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