Search Results - "Kilbourne, E D"

Dissociation of influenza virus hemagglutinin and neuraminidase eliminates their intravirionic antigenic competition by Johansson, B E, Kilbourne, E D

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Supplementation of conventional influenza A vaccine with purified viral neuraminidase results in a balanced and broadened immune response by Johansson, Bert E., Matthews, James T., Kilbourne, Edwin D.

“…Influenza virus neuraminidase was chromatographically extracted from A/Johannesburg/33/94 (H3N2) and used to supplement conventional monovalent H3 JHN2 JH…”
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Purified influenza virus hemagglutinin and neuraminidase are equivalent in stimulation of antibody response but induce contrasting types of immunity to infection by JOHANSSON, B. E, BUCHER, D. J, KILBOURNE, E. D

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Independent and Disparate Evolution in Nature of Influenza A Virus Hemagglutinin and Neuraminidase Glycoproteins by Kilbourne, Edwin D., Johansson, Bert E., Grajower, Bernardo

“…The hemagglutinin (HA) and neuraminidase (NA) external glycoprotein antigens of H1N1 and H3N2 subtypes of epidemiologically important influenza A viruses…”
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Perspectives on Pandemics: A Research Agenda by Kilbourne, Edwin D.

“…During the 20th century, indisputable pandemics of influenza occurred in 1918, 1957, and 1968. The pandemics of 1957 (A/H2N2) and 1968 (A/H3N2) were associated…”
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Immunization with Purified N1 and N2 Influenza Virus Neuraminidases Demonstrates Cross-Reactivity Without Antigenic Competition by Johansson, B. E., Kilbourne, E. D.

“…Based on the absence of serologic cross-reactivity, the neuraminidases (NAs) of influenza A viruses are divided into antigenically discrete subtypes, analogous…”
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Neuraminidase-specific antibody responses to inactivated influenza virus vaccine in young and elderly adults by Powers, D C, Kilbourne, E D, Johansson, B E

“…Little information is available on the potential role of antibody to influenza virus neuraminidase (NA) in vaccine-induced immunity. In the present study,…”
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Antigen-Presenting B Cells and Helper T Cells Cooperatively Mediate Intravirionic Antigenic Competition between Influenza A Virus Surface Glycoproteins by Johansson, Bert E., Moran, Thomas M., Kilbourne, Edwin D.

“…Parenteral vaccination of BALB/c mice primed by infection with H3N2 variants of influenza A virus results in a reduced production of N2 antibody in response to…”
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Purified influenza A virus N2 neuraminidase vaccine is immunogenic and non-toxic in humans by Kilbourne, Edwin D., Couch, Robert B., Kasel, Julius A., Keitel, Wendy A., Cate, Thomas R., Quarles, John H., Grajower, Bemardo, Pokorny, Barbara A., Johansson, Bert E.

“…The immunogenicity and toxicity of a purified influenza virus (N2) neuraminidase vaccine (NAV) were investigated in 88 human subjects aged 18–40, and compared…”
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Differences in the Biological Phenotype of Low-Yielding (L) and High-Yielding (H) Variants of Swine Influenza Virus A/NJ/11/76 Are Associated with Their Different Receptor-Binding Activity by Gambaryan, A.S., Matrosovich, M.N., Bender, C.A., Kilbourne, E.D.

“…Low- (L) and high-yielding (H) variants of A/sw/NJ/11/76 influenza virus were compared for their growth properties in embryonated chicken eggs and MDCK cells…”
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Infection-permissive immunization with influenza virus neuraminidase prevents weight loss in infected mice by Johansson, B E, Grajower, B, Kilbourne, E D

“…In studies of infection of young Balb/c mice with a mouse virulent strain of X-31 (H3N2) influenza A virus we have shown a profound virus dose-related effect…”
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Immunogenicity of influenza A virus N2 neuraminidase produced in insect larvae by baculovirus recombinants by Johansson, Bert E., Price, Peter M., Kilbourne, Edwin D.

“…Influenza A virus neuraminidase (NA) from A/Udorn/72 (H3N2) was expressed by recombinant baculovirus-infected insects. The recombinant NA was enzymatically…”
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Comparative Long-Term Effects in a Mouse Model System of Influenza Whole Virus and Purified Neuraminidase Vaccines Followed by Sequential Infections by Johansson, Bert E., Kilbourne, Edwin D.

“…A comparison of inactivated whole influenza virus vaccine and purified influenza neuraminidase (NA) in BALB/cmice repeatedly challenged by homologous or…”
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Influenza A virus haemagglutinin polymorphism: pleiotropic antigenic variants of A/Shanghai/11/87 (H3N2) virus selected as high yield reassortants by Kilbourne, E. D, Johansson, B. E, Moran, T, Wu, S, Pokorny, B. A, Xu, Xiyan, Cox, N

“…1 Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, 2 Mount Sinai School of Medicine, New York, New York 10029 3…”
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Preparation and characterization of a purified influenza virus neuraminidase vaccine by Hocart, Michael, Grajower, Bernardo, Donabedian, Armen, Pokorny, Barbara, Whitaker, Charles, Kilbourne, Edwin D.

“…Influenza virus neuraminidase (NA) has been shown to induce protective but infection-permissive immunity in experimental animals. Challenge infection following…”
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Immunologic response to influenza virus neuraminidase is influenced by prior experience with the associated viral hemagglutinin. II. Sequential infection of mice simulates human experience by Johansson, BE, Moran, TM, Bona, CA, Popple, SW, Kilbourne, ED

“…In man, vaccination with neuraminidase (NA) in H7N2 virus hybrids elicits greater anti-NA response than does N2 NA in H3N2 conventional vaccine, presumably…”
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Complementation of Recombinant Baculoviruses by Coinfection with Wild-Type Virus Facilitates Production in Insect Larvae of Antigenic Proteins of Hepatitis B Virus and Influenza Virus by Price, Peter M., Reichelderfer, Charles F., Johansson, Bert E., Kilbourne, Edwin D., Acs, George

“…We describe the coinfection of insects with wild-type and recombinant baculoviruses in which the polyhedrin gene promoter is used to express hepatitis B virus…”
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Nonimmunoselected Intrastrain Genetic Variation Detected in Pairs of High-Yielding Influenza a (H3N2) Vaccine and Parental Viruses by Xu, Xiyan, Kilbourne, Edwin D., Hall, Henrietta E., Cox, Nancy J.

“…Seven influenza A (H3N2) high-yielding vaccine candidate strains were examined. Antigenic analysis revealed that 5 of the strains could be distinguished…”
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Hemagglutinin of Swine Influenza Virus: A Single Amino Acid Change Pleiotropically Affects Viral Antigenicity and Replication by Both, Gerald W., Shi, Cheng Hua, Kilbourne, Edwin D.

“…The complete nucleotide sequence has been obtained of the H1 hemagglutinin (HA) gene of a high-yielding (H) mutant of the A/NJ/11/76(H1N1) strain of swine…”
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Identification of PR8 M1 protein in influenza virus high-yield reassortants by M1-specific monoclonal antibodies by Johansson, B E, Bucher, D J, Pokorny, B A, Mikhail, A, Kilbourne, E D

“…A panel of monoclonal antibodies to the M1 protein of A/PR8/34 (H1N1) (PR8) influenza A virus was found to distinguish in ELISA high-yielding reassortant…”
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