Search Results - "Kilbourn, R"

Heterogeneity of Cholinergic Denervation in Parkinson's Disease without Dementia by Bohnen, Nicolaas I, Müller, Martijn L T M, Kotagal, Vikas, Koeppe, Robert A, Kilbourn, Michael R, Gilman, Sid, Albin, Roger L, Frey, Kirk A

“…Parkinson's disease (PD) is a multisystem neurodegenerative disorder. Heterogeneous clinical features may reflect heterogeneous changes in different brain…”
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Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain by Zubieta, Jon-Kar, Smith, Yolanda R., Bueller, Joshua A., Xu, Yanjun, Kilbourn, Michael R., Jewett, Douglas M., Meyer, Charles R., Koeppe, Robert A., Stohler, Christian S.

“…The endogenous opioid system is involved in stress responses, in the regulation of the experience of pain, and in the action of analgesic opiate drugs. We…”
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11C- and 18F-Radiotracers for In Vivo Imaging of the Dopamine System: Past, Present and Future by Kilbourn, Michael R.

“…The applications of positron emission tomography (PET) imaging to study brain biochemistry, and in particular the aspects of dopamine neurotransmission, have…”
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Editorial: Positron Emission Tomography (PET) Imaging of Brain Biochemistry: Beyond High-Affinity Radioligands by Kilbourn, Michael R, Scott, Peter J H, Vasdev, Neil

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Classics in Neuroimaging: Development of PET Tracers for Imaging Monoamine Oxidases by Narayanaswami, Vidya, Drake, Lindsey R, Brooks, Allen F, Meyer, Jeffrey H, Houle, Sylvain, Kilbourn, Michael R, Scott, Peter J. H, Vasdev, Neil

“…In this Viewpoint, we highlight the history of positron emission tomography (PET) radiotracer development to quantify changes in monoamine oxidase (MAO)-A and…”
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Identification of AV-1451 as a Weak, Nonselective Inhibitor of Monoamine Oxidase by Drake, Lindsey R, Pham, Jonathan M, Desmond, Timothy J, Mossine, Andrew V, Lee, So Jeong, Kilbourn, Michael R, Koeppe, Robert A, Brooks, Allen F, Scott, Peter J.H

“…[18F]­AV-1451 is one of the most widely used radiotracers for positron emission tomography (PET) imaging of tau protein aggregates in neurodegenerative…”
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Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease by Bohnen, Nicolaas I, Albm, Roger L, Koeppe, Robert A, Wernette, Kristine A, Kilbourn, Michael R, Minoshima, Satoshi, Frey, Kirk A

“…The type-2 vesicular monoamine transporter (VMAT2) might serve as an objective biomarker of Parkinson disease (PD) severity. Thirty-one subjects with…”
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Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers by JOHANSON, Chris-Ellyn, FREY, Kirk A, SCHUSTER, Charles R, LUNDAHL, Leslie H, KEENAN, Pamela, LOCKHART, Nancy, ROLL, John, GALLOWAY, Gantt P, KOEPPE, Robert A, KILBOURN, Michael R, ROBBINS, Trevor

“…Preclinical investigations have established that methamphetamine (MA) produces long-term changes in dopamine (DA) neurons in the striatum. Human studies have…”
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Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson's disease by Bohnen, Nicolaas I., Müller, Martijn L. T. M., Zarzhevsky, Natalia, Koeppe, Robert A., Bogan, Christopher W., Kilbourn, Michael R., Frey, Kirk A., Albin, Roger L.

“…Leucoaraiosis is associated with motor symptoms in otherwise normal older adults. Comorbid leucoaraiosis is predicted to contribute also to motor features in…”
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High Affinity Radiopharmaceuticals Based Upon Lansoprazole for PET Imaging of Aggregated Tau in Alzheimer’s Disease and Progressive Supranuclear Palsy: Synthesis, Preclinical Evaluation, and Lead Selection by Fawaz, Maria V, Brooks, Allen F, Rodnick, Melissa E, Carpenter, Garrett M, Shao, Xia, Desmond, Timothy J, Sherman, Phillip, Quesada, Carole A, Hockley, Brian G, Kilbourn, Michael R, Albin, Roger L, Frey, Kirk A, Scott, Peter J. H

“…Abnormally aggregated tau is the hallmark pathology of tauopathy neurodegenerative disorders and is a target for development of both diagnostic tools and…”
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mu-opioid receptor-mediated antinociceptive responses differ in men and women by Zubieta, Jon-Kar, Smith, Yolanda R, Bueller, Joshua A, Xu, Yanjun, Kilbourn, Michael R, Jewett, Douglas M, Meyer, Charles R, Koeppe, Robert A, Stohler, Christian S

“…Sex differences in the experience of clinical and experimental pain have been reported. However, the neurobiological sources underlying the variability in pain…”
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Assessment of mild dementia with amyloid and dopamine terminal positron emission tomography by BURKE, James F, ALBIN, Roger L, KOEPPE, Robert A, GIORDANI, Bruno, KILBOURN, Michael R, GILMAN, Sid, FREY, Kirk A

“…We assessed the relationship between consensus clinical diagnostic classification and neurochemical positron emission tomography imaging of striatal vesicular…”
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Fluorine-18 radiopharmaceuticals beyond [18 F]FDG for use in oncology and neurosciences by Coenen, H.H, Elsinga, P.H, Iwata, R, Kilbourn, M.R, Pillai, M.R.A, Rajan, M.G.R, Wagner, H.N, Zaknun, J.J

“…Abstract Positron emission tomography (PET) is a rapidly expanding clinical modality worldwide thanks to the availability of compact medical cyclotrons and…”
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Striatal [11C]dihydrotetrabenazine and [11C]methylphenidate binding in Tourette syndrome by ALBIN, R. L, KOEPPE, R. A, WERNETTE, K, ZHUANG, W, NICHOLS, T, KILBOURN, M. R, FREY, K. A

“…Tourette syndrome (TS) is a common neurodevelopmental disorder marked by tics and behavioral comorbidities. Clinical pharmacology suggests that dopaminergic…”
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Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC) by Jackson, Isaac M., Lee, So Jeong, Sowa, Alexandra R., Rodnick, Melissa E., Bruton, Laura, Clark, Mara, Preshlock, Sean, Rothley, Jill, Rogers, Virginia E., Botti, Leslie E., Henderson, Bradford D., Hockley, Brian G., Torres, Jovany, Raffel, David M., Brooks, Allen F., Frey, Kirk A., Kilbourn, Michael R., Koeppe, Robert A., Shao, Xia, Scott, Peter J. H.

“…Background In the US, EU and elsewhere, basic clinical research studies with positron emission tomography (PET) radiotracers that are generally recognized as…”
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Evaluation of [11C]N‑Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles by Shao, Xia, Carpenter, Garrett M, Desmond, Timothy J, Sherman, Phillip, Quesada, Carole A, Fawaz, Maria, Brooks, Allen F, Kilbourn, Michael R, Albin, Roger L, Frey, Kirk A, Scott, Peter J. H

“…[11C]N-Methyl lansoprazole ([11C]NML, 3) was synthesized and evaluated as a radiopharmaceutical for quantifying tau neurofibrillary tangle (NFT) burden using…”
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Radiochemistry, PET Imaging, and the Internet of Chemical Things by Thompson, Stephen, Kilbourn, Michael R, Scott, Peter J. H

“…The Internet of Chemical Things (IoCT), a growing network of computers, mobile devices, online resources, software suites, laboratory equipment, synthesis…”
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Effects of buprenorphine maintenance dose on μ-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers by GREENWALD, Mark K, JOHANSON, Chris-Ellyn, MOODY, David E, WOODS, James H, KILBOURN, Michael R, KOEPPE, Robert A, SCHUSTER, Charles R, ZUBIETA, Jon-Kar

“…The clinical effectiveness of opioid maintenance for heroin dependence is believed to result from a medication's ability to decrease mu-opioid receptor (muOR)…”
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Small Molecule PET Tracers for Transporter Imaging by Kilbourn, Michael R.

“…As the field of PET has expanded and an ever-increasing number and variety of compounds have been radiolabeled as potential in vivo tracers of biochemistry,…”
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Characterization of optically resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET imaging agent targeting vesicular monoamine transporters by Kung, Mei-Ping, Hou, Catherine, Goswami, Rajesh, Ponde, Datta E, Kilbourn, Michael R, Kung, Hank F

“…Abstract Labeling derivatives of dihydrotetrabenazine (DTBZ) with F-18 ( T1/2 =110 min) instead of C-11 ( T1/2 =20 min) would improve their utility and…”
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