Search Results - "Kilarkaje, Narayana"

Role of progesterone on dexamethasone-induced alterations in placental vascularization and progesterone receptors in rats by Alawadhi, Mariam, Kilarkaje, Narayana, Mouihate, Abdeslam, Al-Bader, Maie D.

“…Background: Intrauterine growth restriction (IUGR) is manifested by lower maternal progesterone levels, smaller placental size, and decreased placental…”
Get full text

Effects of bleomycin, etoposide and cisplatin treatment on Leydig cell structure and transcription of steroidogenic enzymes in rat testis by Al-Bader, Maie, Kilarkaje, Narayana

“…Cytotoxic anticancer chemotherapy affects pituitary–testicular hormonal axis in humans and in animals. This study investigated the effects on Leydig cells of…”
Get full text

Cisplatin induces duplex 3′ overhangs and 5′ blunt ends in epididymal epithelium in a Bax-dependent manner without any protection from l-ascorbic acid by Narayana, Kilarkaje

“…The ability of cisplatin ( cis-diaminedichloroplatinum-II) to induce DNA double-strand breaks and expression of p53, Bax and Bcl-2 and possible protective…”
Get full text

Impaired spatial navigation and age‐dependent hippocampal synaptic dysfunction are associated with chronic inflammatory response in db/db mice by Al‐Onaizi, Mohammed, Al‐Sarraf, Ahmad, Braysh, Kawthar, Kazem, Fatema, Al‐Hussaini, Heba, Rao, Muddanna, Kilarkaje, Narayana, ElAli, Ayman

“…Type 2 diabetes mellitus (T2DM) increases the risk of developing Alzheimer's disease (AD), which has been proposed to be driven by an abnormal…”
Get full text

An aminoglycoside antibiotic gentamycin induces oxidative stress, reduces antioxidant reserve and impairs spermatogenesis in rats by Narayana, Kilarkaje

“…Gentamycin (GS) is an aminoglycoside antibiotic used to treat infections of various Gram-negative organisms. The present study was designed to investigate the…”
Get full text

Antioxidants enhance the recovery of three cycles of bleomycin, etoposide, and cisplatin–induced testicular dysfunction, pituitary-testicular axis, and fertility in rats by Kilarkaje, Narayana, Ph.D, Mousa, Alyaa M., Ph.D, Al-Bader, Maie M., Ph.D, Khan, Khalid M., Ph.D

“…Objective To investigate the effects of an antioxidant cocktail (AC) on bleomycin, etoposide, and cisplatin (BEP)–induced testicular dysfunction. Design…”
Get full text

Molecular effects of chemotherapeutic drugs and their modulation by antioxidants in the testis by Narayana, Kilarkaje, Al-Bader, Maie, Mousa, Alyaa, Khan, Khalid M.

“…Cisplatin-based chemotherapy regimens are preferred in the treatment of a variety of cancers. The present study investigated early cumulative molecular effects…”
Get full text

Maternal dexamethasone exposure does not affect glucose tolerance but alters renal haemodynamics in F1 rats in a sex-dependent manner by Malatiali, Slava A, Narayana Kilarkaje, Al-Bader, Maie

“…IntroductionPrenatal programming with dexamethasone increases the risk of the development of hyperglycaemia and insulin resistance, leading to diabetes in…”
Get full text

A purine nucleoside analogue-acyclovir [9-(2-hydroxyethoxymethyl)-9h−guanine] reversibly impairs testicular functions in mouse by Narayana, Kilarkaje

“…The present study was designed to investigate testicular effects of Acyclovir [9-(2-hydroxyethoxymethyl)-9H−guanine] in mouse. Swiss albino male mice…”
Get full text

Role of angiotensin II and angiotensin-(1–7) in diabetes-induced oxidative DNA damage in the corpus cavernosum by Kilarkaje, Narayana, Ph.D, Yousif, Mariam H.M., Ph.D, El-Hashim, Ahmed Z., Ph.D, Makki, Batoul, M.Sc, Akhtar, Saghir, Ph.D, Benter, Ibrahim F., Ph.D

“…Objective To investigate diabetes mellitus (DM)-induced oxidative DNA damage, putative involvement of angiotensin (Ang) II, and possible modulatory effects of…”
Get full text

A New Technique to Induce Experimental Myointimal Hyperplasia by Asfar, Sami, Shuaib, Ali, Al-Otaibi, Fatemah, Asfar, Sora S., Kilarkaje, Narayana

“…Background: Arterial myointimal hyperplasia (MIH) has a significant impact on the long-term outcomes of vascular procedures such as bypass surgery and…”
Get full text

Dataset of Trans-Resveratrol on diabetes-induced abnormal spermatogenesis, poly (ADP-ribose) polymerase-1 (PARP1) expression in intra-testicular blood vessels, and stage-dependent expression of PARP1 and Sirtuin 1 in the rat testis by Abdelali, Ala׳, Al-Bader, Maie, Kilarkaje, Narayana

“…This article contains data related to the article “Effects of Trans-Resveratrol on hyperglycemia-induced abnormal spermatogenesis, DNA damage and alterations…”
Get full text

Trans-resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys by Al-Hussaini, Heba, Kilarkaje, Narayana

“…Hyperglycemia induces the formation of advanced glycation end products (AGEs) and their receptors (RAGEs), which alter several intracellular signaling…”
Get full text

AN ORGANOPHOSPHATE INSECTICIDE METHYL PARATHION (O- O- DIMETHYL O-4-NITROPHENYL PHOSPHOROTHIOATE) INDUCES CYTOTOXIC DAMAGE AND TUBULAR ATROPHY IN THE TESTIS DESPITE ELEVATED TESTOSTERONE LEVEL IN THE RAT by NARAYANA, Kilarkaje, PRASHANTHI, Narayan, NAYANATARA, Arunkumar, BAIRY, Laxminarayana K., DÕSOUZA, Urban J. A.

“…Methyl parathion (MP) is an organophosphate pesticide used in agriculture, although quite often illegally used indoors to contain insects. The present study…”
Get full text

Resveratrol alleviates diabetes-induced testicular dysfunction by inhibiting oxidative stress and c-Jun N-terminal kinase signaling in rats by Faid, Iman, Al-Hussaini, Heba, Kilarkaje, Narayana

“…Diabetes adversely affects reproductive functions in humans and animals. The present study investigated the effects of Resveratrol on diabetes-induced…”
Get full text

Effects of trans-resveratrol on type 1 diabetes-induced inhibition of retinoic acid metabolism pathway in retinal pigment epithelium of Dark Agouti rats by Al-Hussaini, Heba, Kilarkaje, Narayana

“…Genesis and progression of diabetic retinopathy are due to glucotoxicity-induced changes in intracellular milieu in the retina. This study investigated effects…”
Get full text

Effects of combined treatment of α-tocopherol, l-ascorbic acid, selenium and zinc on bleomycin, etoposide and cisplatin-induced alterations in testosterone synthesis pathway in rats by Kilarkaje, Narayana

“…Purpose To investigate the effects of therapeutically relevant dose levels of bleomycin, etoposide and cisplatin (BEP) on testicular steroidogenic enzymes, and…”
Get full text

Type 1 diabetes upregulates metastasis-associated protein 1- phosphorylated histone 2AX signaling in the testis by Kilarkaje, Narayana, Al-Hussaini, Heba

“…Under the sustained hyperglycemic state, oxidative stress induces irreparable DNA double-strand breaks resulting in germ cell death and testicular atrophy…”
Get full text

Effects of combined treatment of [alpha]-tocopherol, l-ascorbic acid, selenium and zinc on bleomycin, etoposide and cisplatin-induced alterations in testosterone synthesis pathway in rats by Kilarkaje, Narayana

“…To investigate the effects of therapeutically relevant dose levels of bleomycin, etoposide and cisplatin (BEP) on testicular steroidogenic enzymes, and…”
Get full text

Effects of trans-resveratrol on type 1 diabetes-induced up-regulation of apoptosis and mitogen-activated protein kinase signaling in retinal pigment epithelium of Dark Agouti rats by Al-Hussaini, Heba, Kittaneh, Rawan Sharhabeel, Kilarkaje, Narayana

“…Microvascular changes and retinal degeneration precede diabetic retinopathy. Oxidative stress alters several intracellular signaling pathways, which form the…”
Get full text