Search Results - "Kikuzato, Ko"

Triazole Ureas Covalently Bind to Strigolactone Receptor and Antagonize Strigolactone Responses by Nakamura, Hidemitsu, Hirabayashi, Kei, Miyakawa, Takuya, Kikuzato, Ko, Hu, Wenqian, Xu, Yuqun, Jiang, Kai, Takahashi, Ikuo, Niiyama, Ruri, Dohmae, Naoshi, Tanokura, Masaru, Asami, Tadao

“…Strigolactones, a class of plant hormones with multiple functions, mediate plant–plant and plant–microorganism communications in the rhizosphere. In this…”
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Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents by Nishigaya, Yosuke, Takase, Shohei, Sumiya, Tatsunobu, Kikuzato, Ko, Sato, Tomohiro, Niwa, Hideaki, Sato, Shin, Nakata, Akiko, Sonoda, Takeshi, Hashimoto, Noriaki, Namie, Ryosuke, Honma, Teruki, Umehara, Takashi, Shirouzu, Mikako, Koyama, Hiroo, Yoshida, Minoru, Ito, Akihiro, Shirai, Fumiyuki

“…Identification of structurally novel inhibitors of lysine methyltransferase G9a has been a subject of intense research in cancer epigenetics. Starting with the…”
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Aminooxy‐naphthylpropionic acid and its derivatives are inhibitors of auxin biosynthesis targeting l‐tryptophan aminotransferase: structure–activity relationships by Narukawa‐Nara, Megumi, Nakamura, Ayako, Kikuzato, Ko, Kakei, Yusuke, Sato, Akiko, Mitani, Yuka, Yamasaki‐Kokudo, Yumiko, Ishii, Takahiro, Hayashi, Ken‐ichiro, Asami, Tadao, Ogura, Takehiko, Yoshida, Shigeo, Fujioka, Shozo, Kamakura, Takashi, Kawatsu, Tsutomu, Tachikawa, Masanori, Soeno, Kazuo, Shimada, Yukihisa

“…Summary We previously reported l‐α‐aminooxy‐phenylpropionic acid (AOPP) to be an inhibitor of auxin biosynthesis, but its precise molecular target was not…”
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An ex vivo screening using mouse brain mitochondria identified seco-cycline D as an inhibitor of mitochondrial permeability transition pore by Kubota-Sakashita, Mie, Kawakami, Hirochika, Kikuzato, Ko, Shirai, Fumiyuki, Nakamura, Takemichi, Kato, Tadafumi

“…Mitochondrial dysfunction is implicated in neuropsychiatric disorders. Inhibition of mitochondrial permeability transition pore (mPTP) and thereby enhancement…”
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New antimalarials identified by a cell-based phenotypic approach: Structure–activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety by Cho, Nobuo, Kikuzato, Ko, Futamura, Yushi, Shimizu, Takeshi, Hayase, Hiroki, Kamisaka, Kikuko, Takaya, Daisuke, Yuki, Hitomi, Honma, Teruki, Niikura, Mamoru, Kobayashi, Fumie, Watanabe, Nobumoto, Osada, Hiroyuki, Koyama, Hiroo

“…[Display omitted] The identification, structure–activity relationships (SARs), and biological effects of new antimalarials consisting of a…”
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OA-35 Discovery of a Novel Class MMSET Inhibitor With Specificity for t(4; 14)-Positive Multiple Myeloma by Matsuoka, Sae, Osada, Naoki, Kubota, Hirokazu, Kikuzato, Ko, Koyama, Hiroo, Sonoda, Takeshi, Ide, Akiko, Yoshida, Minoru, Kikuchi, Masaki, Umehara, Takashi, Watanabe, Chiduru, Honma, Teruki, Yasui, Hiroshi, Ikeda, Sho, Takahashi, Naoto, Nakasone, Hideki, Kikuchi, Jiro, Furukawa, Yusuke

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Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen by Yuki, Hitomi, Kikuzato, Ko, Koda, Yasuko, Mikuni, Junko, Tomabechi, Yuri, Kukimoto-Niino, Mutsuko, Tanaka, Akiko, Shirai, Fumiyuki, Shirouzu, Mikako, Koyama, Hiroo, Honma, Teruki

“…[Display omitted] We previously reported the structure-based design of a highly potent hematopoietic cell kinase (HCK) inhibitor, a pyrrolo-pyrimidine compound…”
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Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors by Koda, Yasuko, Kikuzato, Ko, Mikuni, Junko, Tanaka, Akiko, Yuki, Hitomi, Honma, Teruki, Tomabechi, Yuri, Kukimoto-Niino, Mutsuko, Shirouzu, Mikako, Shirai, Fumiyuki, Koyama, Hiroo

“…Identification of HCK and FLT3-ITD dual inhibitors. [Display omitted] A series of novel pyrrolo[2,3-d]pyrimidines were synthesized by introducing 15 different…”
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