Search Results - "Kikuchi, Tetsuro"

Is Memantine Effective as an NMDA-Receptor Antagonist in Adjunctive Therapy for Schizophrenia? by Kikuchi, Tetsuro

“…Memantine, an -methyl-d-aspartate (NMDA) receptor antagonist approved for treating Alzheimer's disease, has a good safety profile and is increasingly being…”
Get full text

Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration by Ohgi, Yuta, Futamura, Takashi, Kikuchi, Tetsuro, Hashimoto, Kenji

“…Accumulating evidence suggests that inflammation may play a role in the pathophysiology of major depressive disorder (MDD). Antidepressants, including…”
Get full text

Variation of iron redox kinetics and its relation with molecular composition of standard humic substances at circumneutral pH by Lee, Ying Ping, Fujii, Manabu, Kikuchi, Tetsuro, Terao, Koumei, Yoshimura, Chihiro

“…Oxidation and reduction kinetics of iron (Fe) and proportion of steady-state Fe(II) concentration relative to total dissolved Fe (steady-state Fe(II) fraction)…”
Get full text

Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator by Maeda, Kenji, Sugino, Haruhiko, Akazawa, Hitomi, Amada, Naoki, Shimada, Jun, Futamura, Takashi, Yamashita, Hiroshi, Ito, Nobuaki, McQuade, Robert D, Mørk, Arne, Pehrson, Alan L, Hentzer, Morten, Nielsen, Vibeke, Bundgaard, Christoffer, Arnt, Jørn, Stensbøl, Tine Bryan, Kikuchi, Tetsuro

“…Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for…”
Get more information

Correlations between aromaticity of dissolved organic matter and trace metal concentrations in natural and effluent waters: A case study in the Sagami River Basin, Japan by Kikuchi, Tetsuro, Fujii, Manabu, Terao, Koumei, Jiwei, Ran, Lee, Ying Ping, Yoshimura, Chihiro

“…Chemical speciation, reactivity, and bioavailability of trace metals in aqueous systems arestrongly influenced by dissolved organic matter (DOM). DOM is a…”
Get full text

An open-label, positron emission tomography study of the striatal D2/D3 receptor occupancy and pharmacokinetics of single-dose oral brexpiprazole in healthy participants by Wong, Dean F., Raoufinia, Arash, Bricmont, Patricia, Brašić, James R., McQuade, Robert D., Forbes, Robert A., Kikuchi, Tetsuro, Kuwabara, Hiroto

“…Purpose The aim of this Phase 1, open-label, positron emission tomography (PET) study was to determine the degree of striatal D 2 /D 3 receptor occupancy…”
Get full text

Brexpiprazole II: antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulator by Maeda, Kenji, Lerdrup, Linda, Sugino, Haruhiko, Akazawa, Hitomi, Amada, Naoki, McQuade, Robert D, Stensbøl, Tine Bryan, Bundgaard, Christoffer, Arnt, Jørn, Kikuchi, Tetsuro

“…Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel serotonin-dopamine activity modulator with partial…”
Get more information

Effect of dissolved organic matter on Fe(II) oxidation in natural and engineered waters by Lee, Ying Ping, Fujii, Manabu, Terao, Koumei, Kikuchi, Tetsuro, Yoshimura, Chihiro

“…Fe(II) oxidation was investigated in samples from the Sagami River basin (Japan) with particular emphasis on the effect of dissolved organic matter (DOM) in an…”
Get full text

Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: A role for serotonin 5-HT1A receptors by Yoshimi, Noriko, Fujita, Yuko, Ohgi, Yuta, Futamura, Takashi, Kikuchi, Tetsuro, Hashimoto, Kenji

“…Brexpiprazole, a serotonin-dopamine activity modulator, is currently being tested in clinical trials as a new therapy for a number of neuropsychiatric…”
Get full text

Discovery research and development history of the dopamine D2 receptor partial agonists, aripiprazole and brexpiprazole by Kikuchi, Tetsuro, Maeda, Kenji, Suzuki, Mikio, Hirose, Tsuyoshi, Futamura, Takashi, McQuade, Robert D.

“…Otsuka Pharmaceutical Co., Ltd. successfully developed the first dopamine D2 receptor partial agonist approved for schizophrenia, the antipsychotic…”
Get full text

Importance of allochthonous and autochthonous dissolved organic matter in Fe(II) oxidation: A case study in Shizugawa Bay watershed, Japan by Lee, Ying Ping, Fujii, Manabu, Kikuchi, Tetsuro, Natsuike, Masafumi, Ito, Hiroaki, Watanabe, Toru, Yoshimura, Chihiro

“…Ferrous iron (Fe[II]) oxidation by dissolved oxygen was investigated in the Shizugawa Bay watershed with particular attention given to the effect of dissolved…”
Get full text

Correction to: An open-label, positron emission tomography study of the striatal D2/D3 receptor occupancy and pharmacokinetics of single-dose oral brexpiprazole in healthy participants by Wong, Dean F., Raoufinia, Arash, Bricmont, Patricia, Brašić, James R., McQuade, Robert D., Forbes, Robert A., Kikuchi, Tetsuro, Kuwabara, Hiroto

“…A Correction to this paper has been published: https://doi.org/10.1007/s00228-020-03071-z…”
Get full text

Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin–dopamine activity modulator: A role for serotonin 5-HT1A and 5-HT2A receptors by Ishima, Tamaki, Futamura, Takashi, Ohgi, Yuta, Yoshimi, Noriko, Kikuchi, Tetsuro, Hashimoto, Kenji

“…Abstract Brexpiprazole, a novel atypical antipsychotic drug, is currently being tested in clinical trials for treatment of psychiatric disorders, such as…”
Get full text

Synergistic anti‐depressive effect of combination treatment of Brexpiprazole and selective serotonin reuptake inhibitors on forced swimming test in mice by Amada, Naoki, Hirose, Tsuyoshi, Suzuki, Mikio, Kakumoto, Yusuke, Futamura, Takashi, Maeda, Kenji, Kikuchi, Tetsuro

“…Aim Selective serotonin reuptake inhibitors (SSRIs) are used to treat major depressive disorder (MDD) and other psychiatric disorders (e.g., obsessive…”
Get full text

Brexpiprazole has a low risk of dopamine D2 receptor sensitization and inhibits rebound phenomena related to D2 and serotonin 5‐HT2A receptors in rats by Amada, Naoki, Akazawa, Hitomi, Ohgi, Yuta, Maeda, Kenji, Sugino, Haruhiko, Kurahashi, Nobuyuki, Kikuchi, Tetsuro, Futamura, Takashi

“…Background Long‐term antipsychotic treatment in patients with schizophrenia can induce supersensitivity psychosis and tardive dyskinesia which is thought to be…”
Get full text

Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors by Burris, Kevin D, Molski, Thaddeus F, Xu, Cen, Ryan, Elaine, Tottori, Katsura, Kikuchi, Tetsuro, Yocca, Frank D, Molinoff, Perry B

“…Aripiprazole is the first next-generation atypical antipsychotic with a mechanism of action that differs from currently marketed typical and atypical…”
Get more information

The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor by JORDAN, Shaun, KOPRIVICA, Vuk, RUOYAN CHEN, TOTTORI, Katsura, KIKUCHI, Tetsuro, ALTAR, C. Anthony

“…Aripiprazole, 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy]-3,4-dihydro-2(1H)-quinolinone, a novel antipsychotic with partial agonist activity at…”
Get full text

Functional potencies of dopamine agonists and antagonists at human dopamine D2 and D3 receptors by TADORI, Yoshihiro, FORBES, Robert A, MCQUADE, Robert D, KIKUCHI, Tetsuro

“…We measured the functional agonist potencies of dopamine agonists including antiparkinson drugs, and functional antagonist potencies of antipsychotics at human…”
Get full text

Characterization of aripiprazole partial agonist activity at human dopamine D3 receptors by TADORI, Yoshihiro, FORBES, Robert A, MCQUADE, Robert D, KIKUCHI, Tetsuro

“…Aripiprazole is the first dopamine D2/D3 receptor partial agonist approved for use in the treatment of psychiatric disorders, including schizophrenia, bipolar…”
Get full text

Aripiprazole protects cortical neurons from glutamate toxicity by Koprivica, Vuk, Regardie, Karen, Wolff, Christina, Fernalld, Raymond, Murphy, Janelle Johnson, Kambayashi, Junichi, Kikuchi, Tetsuro, Jordan, Shaun

“…Neurodegeneration is thought to be a component of schizophrenia pathology, and some antipsychotics appear to slow degenerative changes in patients…”
Get full text