Search Results - "Kikly, K"

Caspase-8 and Caspase-3 Are Expressed by Different Populations of Cortical Neurons Undergoing Delayed Cell Death after Focal Stroke in the Rat by Velier, James J, Ellison, Julie A, Kikly, Kristine K, Spera, Patricia A, Barone, Frank C, Feuerstein, Giora Z

“…A number of studies have provided evidence that neuronal cell loss after stroke involves programmed cell death or apoptosis. In particular, recent biochemical…”
Get full text

Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils by Kikly, Kristine K., Bochner, Bruce S., Freeman, Sylvie D., Tan, K.B., Gallagher, Kathleen T., D’Alessio, Karla J., Holmes, Stephen D., Abrahamson, Julie A., Erickson-Miller, Connie L., Murdock, Paul R., Tachimoto, Hiroshi, Schleimer, Robert P., White, John R.

“…Background: Eosinophils, basophils, and mast cells are believed to be the central tenet cells in allergic conditions including allergic rhinitis, asthma, and…”
Get full text

Pro-caspase-8 Is Predominantly Localized in Mitochondria and Released into Cytoplasm upon Apoptotic Stimulation by Qin, Zheng-Hong, Wang, Yumei, Kikly, Kristine K., Sapp, Ellen, Kegel, Kimberly B., Aronin, Neil, DiFiglia, Marian

“…The recruitment and cleavage of pro-caspase-8 to produce the active form of caspase-8 is a critical biochemical event in death receptor-mediated apoptosis…”
Get full text

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 by Lee, Dennis, Long, Scott A, Murray, Jeffrey H, Adams, Jerry L, Nuttall, Mark E, Nadeau, Daniel P, Kikly, Kristine, Winkler, James D, Sung, Chiu-Mei, Ryan, M. Dominic, Levy, Mark A, Keller, Paul M, DeWolf, Walter E

“…5-Dialkylaminosulfonylisatins have been identified as potent, nonpeptide inhibitors of caspases 3 and 7. The most active compound within this series (34)…”
Get full text

A Modified Metal-Ion Affinity Chromatography Procedure for the Purification of Histidine-Tagged Recombinant Proteins Expressed in Drosophila S2 Cells by Lehr, Ruth V., Elefante, Louis C., Kikly, Kristine K., O'Brien, Shawn P., Kirkpatrick, Robert B.

“…We have developed a modified method of immobilized metal-ion affinity chromatography (IMAC) that can be used for the purification of histidine-tagged proteins…”
Get full text

Characterization of Siglec-5 (CD170) expression and functional activity of anti–Siglec-5 antibodies on human phagocytes by Erickson-Miller, Connie L., Freeman, Sylvie D., Hopson, Christopher B., D'Alessio, Karla J., Fischer, Elizabeth I., Kikly, Kristine K., Abrahamson, Julie A., Holmes, Stephen D., King, Andrew G.

“…Objective. The Siglec family of proteins consists of at least 10 members with immunoglobulin and lectin domains and with similar sialic acid–binding…”
Get full text

Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A by Liu, Ling, Lu, Jirong, Allan, Barrett W, Tang, Ying, Tetreault, Jonathan, Chow, Chi-Kin, Barmettler, Barbra, Nelson, James, Bina, Holly, Huang, Lihua, Wroblewski, Victor J, Kikly, Kristine

“…Interleukin (IL)-17A exists as a homodimer (A/A) or as a heterodimer (A/F) with IL-17F. IL-17A is expressed by a subset of T-cells, called Th17 cells, at…”
Get full text

Cloning of a Type I Cytokine Receptor Most Related to the IL-2 Receptor β Chain by Ozaki, Katsutoshi, Kikly, Kristine, Michalovich, David, Young, Peter R., Leonard, Warren J.

“…We have identified a type I cytokine receptor, which we have termed novel interleukin receptor (NILR), that is most related to the IL-2 receptor β chain…”
Get full text

Generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor by Manetta, Joseph, Bina, Holly, Ryan, Paul, Fox, Niles, Witcher, Derrick R, Kikly, Kristine

“…B-cell activating factor (BAFF) is a B-cell survival factor with a key role in B-cell homeostasis and tolerance. Dysregulated BAFF expression may contribute to…”
Get full text

Caspase-8 Is an Effector in Apoptotic Death of Dopaminergic Neurons in Parkinson's Disease, But Pathway Inhibition Results in Neuronal Necrosis by Hartmann, Andreas, Troadec, Jean-Denis, Hunot, Stephane, Kikly, Kristy, Faucheux, Baptiste A, Mouatt-Prigent, Annick, Ruberg, Merle, Agid, Yves, Hirsch, Etienne C

“…Caspase-8 is a proximal effector protein of the tumor necrosis factor receptor family death pathway. In the present human postmortem study, we observed a…”
Get full text

B7‐H3 promotes acute and chronic allograft rejection by Wang, Liqing, Fraser, Christopher C., Kikly, Kristine, Wells, Andrew D., Han, Rongxiang, Coyle, Anthony J., Chen, Lieping, Hancock, Wayne W.

“…The B7 homolog B7‐H3 is important for the regulation of immune responses though its functions in vivo are controversial. We report the first clinical and…”
Get full text

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality by Lee, Dennis, Long, Scott A., Adams, Jerry L., Chan, George, Vaidya, Kalindi S., Francis, Terry A., Kikly, Kristine, Winkler, James D., Sung, Chiu-Mei, Debouck, Christine, Richardson, Susan, Levy, Mark A., DeWolf, Walter E., Keller, Paul M., Tomaszek, Thaddeus, Head, Martha S., Ryan, M.Dominic, Haltiwanger, R.Curtis, Liang, Po-Huang, Janson, Cheryl A., McDevitt, Patrick J., Johanson, Kyung, Concha, Nestor O., Chan, Winnie, Abdel-Meguid, Sherin S., Badger, Alison M., Lark, Michael W., Nadeau, Daniel P., Suva, Larry J., Gowen, Maxine, Nuttall, Mark E.

“…Caspases have been strongly implicated to play an essential role in apoptosis. A critical question regarding the role(s) of these proteases is whether…”
Get full text

Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog by Cacalano, Grace, Lee, James, Kikly, Kristine, Ryan, Ann M., Pitts-Meek, Sharon, Hultgren, Bruce, Wood, William I., Moore, Mark W.

“…Interleukin-8 (IL-8) is a proinflammatory cytokine that specifically attracts and activates human neutrophils. A murine gene with a high degree of homology to…”
Get full text

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice by Erickson, Sharon L, de Sauvage, Frederic J, Kikly, Kristine, Carver-Moore, Karen, Pitts-Meek, Sharon, Gillett, Nancy, Sheehan, Kathleen C. F, Schreiber, Robert D, Goeddel, David V, Moore, Mark W

“…Tumour necrosis factor (TNF) elicits multiple biological effects through two distinct cell surface receptors, TNF-R1 (p55) and TNF-R2 (p75). Most TNF-mediated…”
Get full text

Staurosporine-induced Apoptosis in Cardiomyocytes: A Potential Role of Caspase-3 by Yue, Tian-Li, Wang, Chuanlin, Romanic, Anne M, Kikly, Kristine, Keller, Paul, DeWolf Jr, Watler E, Hart, Timothy K, Thomas, Heath C, Storer, Barbara, Gu, Juan-Li, Wang, Xinkang, Feuerstein, Giora Z

“…Cardiomyocyte apoptosis has been demonstrated in animal models of cardiac injury as well as in patients with congestive heart failure or acute myocardial…”
Get full text

Evidence for extrathymic development of TNK cells. NK1+ CD3+ cells responsible for acute marrow graft rejection are present in thymus- deficient mice by Kikly, K, Dennert, G

“…The predominant mechanism responsible for acute specific rejection of allogeneic and parental bone marrow by irradiated mice is due to a cell (TNK) that…”
Get full text

Evidence for a role for T cell receptors (TCR) in the effector phase of acute bone marrow graft rejection. TCR V beta 5 transgenic mice lack effector cells able to cause graft rejection by Kikly, K, Dennert, G

“…Lethally irradiated mice reject within 24 h certain marrow grafts, a phenomenon called either allogeneic or hybrid resistance. The cells responsible for this…”
Get full text

Synthesis of procaspases-3 and -7 during apoptosis in prostate cancer cells by Bowen, C, Voeller, H J, Kikly, K, Gelmann, E P

“…Cells differ in the time required to execute cell death after receipt of a death signal. One reason may be the requirement for de novo synthesis of components…”
Get full text

Apoptosis in polycystic kidney disease: involvement of caspases by Ali, S M, Wong, V Y, Kikly, K, Fredrickson, T A, Keller, P M, DeWolf, Jr, W E, Lee, D, Brooks, D P

“…Polycystic kidney disease (PKD) is characterized by the development of large renal cysts and progressive loss of renal function. Although the cause of the…”
Get more information

Evidence for a role for T cell receptors (TCR) in the effector phase of acute bone marrow graft rejection : TCR VB5 transfenic mice lack effector cells to cause graft rejection by KIKLY, K, DENNERT, G

Get full text