Search Results - "Kikkawa, Yamato"

Octa-arginine and Octa-lysine Promote Cell Adhesion through Heparan Sulfate Proteoglycans and Integrins by Yamada, Yuji, Onda, Toru, Hamada, Keisuke, Kikkawa, Yamato, Nomizu, Motoyoshi

“…Octa-arginine (R8) has been extensively studied as a cell-penetrating peptide. R8 binds to diverse transmembrane heparan sulfate proteoglycans (HSPGs),…”
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Effect of Amino Acid Substitution on Cell Adhesion Properties of Octa-arginine by Yamada, Yuji, Onda, Toru, Hamada, Keisuke, Kikkawa, Yamato, Nomizu, Motoyoshi

“…Octa-arginine (R8) is a cell-permeable peptide with excellent cell adhesion properties. Surface-immobilized R8 mediates cell attachment via cell surface…”
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α1- and α5-containing Laminins Regulate the Development of Bile Ducts via β1 Integrin Signals by Tanimizu, Naoki, Kikkawa, Yamato, Mitaka, Toshihiro, Miyajima, Atsushi

“…Signals derived from basal lamina components are important for developing three-dimensional architecture of epithelial tissues. Laminins consisting of α, β,…”
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Chain-specificity of laminin α1-5 LG45 modules in the recognition of carbohydrate-linked receptors and intramolecular binding by Matsunuma, Masumi, Kan, Ryuji, Yamada, Yuji, Hamada, Keisuke, Kanagawa, Motoi, Nomizu, Motoyoshi, Kikkawa, Yamato

“…Laminins are a family of heterotrimers composed of α-, β-, and γ-chains in the basement membrane. Five α chains contain laminin globular (LG) domain consisting…”
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Tissue substructure-specific deposition of the β3-containing laminin-332 in the biliary epithelium of human and mouse livers by Yamada, Minami, Okada, Hajime, Kikkawa, Yamato, Miyajima, Atsushi, Itoh, Tohru

“…Laminin is a family of basement membrane proteins, whose selective and spatiotemporal expression profiles are linked to their various functions in development,…”
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Structural Requirement of hA5G18 Peptide (DDFVFYVGGYPS) from Laminin α5 Chain for Amyloid-like Fibril Formation and Cell Adhesion by Zhang, Guangrui, Yamada, Yuji, Kumai, Jun, Hamada, Keisuke, Kikkawa, Yamato, Nomizu, Motoyoshi

“…The hA5G18 peptide (DDFVFYVGGYPS) identified from the human laminin α5 chain G domain promotes cell attachment and spreading when directly coated on a plastic…”
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Laminin-521 Protein Therapy for Glomerular Basement Membrane and Podocyte Abnormalities in a Model of Pierson Syndrome by Lin, Meei-Hua, Miller, Joseph B, Kikkawa, Yamato, Suleiman, Hani Y, Tryggvason, Karl, Hodges, Bradley L, Miner, Jeffrey H

“…Laminin 5 2 1 (LM-521) is a major component of the GBM. Mutations in that prevent LM-521 synthesis and/or secretion cause Pierson syndrome, a rare congenital…”
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Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases by Eremina, Vera, Sood, Manish, Haigh, Jody, Nagy, András, Lajoie, Ginette, Ferrara, Napoleone, Gerber, Hans-Peter, Kikkawa, Yamato, Miner, Jeffrey H, Quaggin, Susan E

“…Kidney disease affects over 20 million people in the United States alone. Although the causes of renal failure are diverse, the glomerular filtration barrier…”
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Evaluation of extracellular matrix mimetic laminin bioactive peptide and elastin‐like polypeptide by Truong, Anh Tan, Hamada, Keisuke, Yamada, Yuji, Guo, Hao, Kikkawa, Yamato, Okamoto, Curtis T., MacKay, J. Andrew, Nomizu, Motoyoshi

“…The extracellular matrix (ECM) is comprised of a large network of proteins that are essential for tissue development and repair. A bioactive RGD‐containing…”
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Development of a Screening System for Targeting Carriers Using Peptide-Modified Liposomes and Tissue Sections by Negishi, Yoichi, Hamano, Nobuhito, Sato, Hinako, Katagiri, Fumihiko, Takatori, Kyohei, Endo-Takahashi, Yoko, Kikkawa, Yamato, Nomizu, Motoyoshi

“…Liposomes have been used as targeting carriers for drug delivery systems (DDSs), and the carriers are able to be modified with targeting ligands, such as…”
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Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases by Eremina, Vera, Sood, Manish, Haigh, Jody, Nagy, András, Lajoie, Ginette, Ferrara, Napoleone, Gerber, Hans-Peter, Kikkawa, Yamato, Miner, Jeffrey H., Quaggin, Susan E.

“…Kidney disease affects over 20 million people in the United States alone. Although the causes of renal failure are diverse, the glomerular filtration barrier…”
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Development of a bispecific DNA-aptamer-based lysosome-targeting chimera for HER2 protein degradation by Hamada, Keisuke, Hashimoto, Ten, Iwashita, Rinoka, Yamada, Yuji, Kikkawa, Yamato, Nomizu, Motoyoshi

“…Human epidermal growth factor receptor 2 (HER2) is highly expressed in breast cancers and is strongly associated with cancer recurrence and prognosis…”
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Identification of active sequences in human laminin α5 G domain by Kumai, Jun, Yamada, Yuji, Hamada, Keisuke, Katagiri, Fumihiko, Hozumi, Kentaro, Kikkawa, Yamato, Nomizu, Motoyoshi

“…Human laminin‐511 (α5β1γ1) and its truncated protein, laminin‐511 E8 fragment, bind to integrin α6β1 and have been widely used for embryonic stem cell and…”
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Suppression of cell adhesion through specific integrin crosstalk on mixed peptide-polysaccharide matrices by Hozumi, Kentaro, Fujimori, Chikara, Katagiri, Fumihiko, Kikkawa, Yamato, Nomizu, Motoyoshi

“…Abstract Crosstalk of different integrins, which bind to distinct types of extracellular matrix proteins, promotes specific functions. This crosstalk has not…”
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The Lutheran/Basal Cell Adhesion Molecule Promotes Tumor Cell Migration by Modulating Integrin-mediated Cell Attachment to Laminin-511 Protein by Kikkawa, Yamato, Ogawa, Takaho, Sudo, Ryo, Yamada, Yuji, Katagiri, Fumihiko, Hozumi, Kentaro, Nomizu, Motoyoshi, Miner, Jeffrey H.

“…Cell-matrix interactions are critical for tumor cell migration. Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM), competes with integrins for…”
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Roles of Lu/B-CAM in tumor cell adhesion and migration on laminin-511 by Kikkawa, Yamato

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Laminin active peptide/agarose matrices as multifunctional biomaterials for tissue engineering by Yamada, Yuji, Hozumi, Kentaro, Aso, Akihiro, Hotta, Atsushi, Toma, Kazunori, Katagiri, Fumihiko, Kikkawa, Yamato, Nomizu, Motoyoshi

“…Abstract Cell adhesive peptides derived from extracellular matrix components are potential candidates to afford bio-adhesiveness to cell culture scaffolds for…”
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Down-regulation of cell adhesion via rho-associated protein kinase (ROCK) pathway promotes tumor cell migration on laminin-511 by Kikkawa, Yamato, Harashima, Nozomi, Ikari, Kazuki, Fujii, Shogo, Katagiri, Fumihiko, Hozumi, Kentaro, Nomizu, Motoyoshi

“…Epithelial cells, both normal and precancerous, stably anchor to basement membranes, whereas malignant tumors pass through them to achieve metastasis. Of…”
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Internalization of CD239 highly expressed in breast cancer cells: a potential antigen for antibody-drug conjugates by Kikkawa, Yamato, Enomoto-Okawa, Yurie, Fujiyama, Aiko, Fukuhara, Takeshi, Harashima, Nozomi, Sugawara, Yumika, Negishi, Yoichi, Katagiri, Fumihiko, Hozumi, Kentaro, Nomizu, Motoyoshi, Ito, Yuji

“…Antibody–drug conjugates (ADCs) are attractive in cancer therapy because they can directly bind to cancer cells and provide anticancer activity. To kill cancer…”
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Effect of spacer length and type on the biological activity of peptide-polysaccharide matrices by Kumai, Jun, Hozumi, Kentaro, Yamada, Yuji, Katagiri, Fumihiko, Kikkawa, Yamato, Nomizu, Motoyoshi

“…ABSTRACT Peptide–polysaccharide matrices can mimic extracellular matrix structure and function and are useful for tissue and cell engineering. The spacer…”
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