Search Results - "Kikkawa, Ushio"

The story of PKC: A discovery marked by unexpected twists and turns by Kikkawa, Ushio

“…Protein kinase C (PKC) is activated by 1,2‐diacylglycerol as a second messenger in the signaling mechanism coupled with the hydrolysis of membrane inositol…”
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Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly by Kaizuka, Takeshi, Hara, Taichi, Oshiro, Noriko, Kikkawa, Ushio, Yonezawa, Kazuyoshi, Takehana, Kenji, Iemura, Shun-ichiro, Natsume, Tohru, Mizushima, Noboru

“…Mammalian target of rapamycin (mTOR) is a member of the phosphatidylinositol 3-kinase-related kinase (PIKK) family and is a major regulator of translation,…”
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Proline dehydrogenase promotes senescence through the generation of reactive oxygen species by Nagano, Taiki, Nakashima, Akio, Onishi, Kengo, Kawai, Kosuke, Awai, Yuto, Kinugasa, Mizuki, Iwasaki, Tetsushi, Kikkawa, Ushio, Kamada, Shinji

“…Cellular senescence is a complex stress response characterized by permanent loss of proliferative capacity and is implicated in age-related disorders. Although…”
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Identification of cellular senescence-specific genes by comparative transcriptomics by Nagano, Taiki, Nakano, Masayuki, Nakashima, Akio, Onishi, Kengo, Yamao, Shunsuke, Enari, Masato, Kikkawa, Ushio, Kamada, Shinji

“…Cellular senescence is defined as permanent cell cycle arrest induced by various stresses. Although the p53 transcriptional activity is essential for…”
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Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells by Yang, Wen-Bin, Wu, An-Chih, Hsu, Tsung-I, Liou, Jing-Ping, Lo, Wei-Lun, Chang, Kwang-Yu, Chen, Pin-Yuan, Kikkawa, Ushio, Yang, Shung-Tai, Kao, Tzu-Jen, Chen, Ruei-Ming, Chang, Wen-Chang, Ko, Chiung-Yuan, Chuang, Jian-Ying

“…DNA repair promotes the progression and recurrence of glioblastoma (GBM). However, there remain no effective therapies for targeting the DNA damage response…”
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The Proline-rich Akt Substrate of 40 kDa (PRAS40) Is a Physiological Substrate of Mammalian Target of Rapamycin Complex 1 by Oshiro, Noriko, Takahashi, Rinako, Yoshino, Ken-ichi, Tanimura, Keiko, Nakashima, Akio, Eguchi, Satoshi, Miyamoto, Takafumi, Hara, Kenta, Takehana, Kenji, Avruch, Joseph, Kikkawa, Ushio, Yonezawa, Kazuyoshi

“…The proline-rich Akt substrate of 40 kilodaltons (PRAS40) was identified as a raptor-binding protein that is phosphorylated directly by mammalian target of…”
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Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation by Tsai, Yu-Ting, Lo, Wei-Lun, Chen, Pin-Yuan, Ko, Chiung-Yuan, Chuang, Jian-Ying, Kao, Tzu-Jen, Yang, Wen-Bing, Chang, Kwang-Yu, Hung, Chia-Yang, Kikkawa, Ushio, Chang, Wen-Chang, Hsu, Tsung-I

“…Sp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement of resistance to temozolomide (TMZ). Particularly, the role of Sp1 in metabolic…”
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Nuclear Translocation of Caspase-3 Is Dependent on Its Proteolytic Activation and Recognition of a Substrate-like Protein(s) by Kamada, Shinji, Kikkawa, Ushio, Tsujimoto, Yoshihide, Hunter, Tony

“…Caspase-3 is thought to play an important role(s) in the nuclear morphological changes that occur in apoptotic cells and many nuclear substrates for caspase-3…”
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Protein Kinase Cδ (PKCδ): Activation Mechanisms and Functions by Kikkawa, Ushio, Matsuzaki, Hidenori, Yamamoto, Toshiyoshi

“…Protein kinase C (PKC)δ was the first new/novel PKC isoform to be identified by the screening of mammalian cDNA libraries, based on the structural homology of…”
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Midostaurin preferentially attenuates proliferation of triple-negative breast cancer cell lines through inhibition of Aurora kinase family by Kawai, Masaaki, Nakashima, Akio, Kamada, Shinji, Kikkawa, Ushio

“…Breast cancer is classified into three subtypes by the expression of biomarker receptors such as hormone receptors and human epidermal growth factor receptor…”
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The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast by Ma, Ning, Ma, Yan, Nakashima, Akio, Kikkawa, Ushio, Furuyashiki, Tomoyuki

“…In mammalian cells, mTORC1 activity is regulated by Rag GTPases. It is thought that the Ragulator complex and the GATOR (GAP activity towards Rags) complex…”
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Growth hormone and Insulin-like growth factor-I (IGF-I) modulate the expression of L-type amino acid transporters in the muscles of spontaneous dwarf rats and L6 and C2C12 myocytes by Sawa, Ran, Nishida, Hikaru, Yamamoto, Yu, Wake, Ikumi, Kai, Noriko, Kikkawa, Ushio, Okimura, Yasuhiko

“…Branched-chain amino acids (BCAAs) have been reported to inhibit several types of muscle atrophy via the activation of the mechanistic target of rapamycin…”
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HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells by Wu, An-Chih, Yang, Wen-Bin, Chang, Kwang-Yu, Lee, Jung-Shun, Liou, Jing-Ping, Su, Ruei-Yuan, Cheng, Siao Muk, Hwang, Daw-Yang, Kikkawa, Ushio, Hsu, Tsung-I, Wang, Chih-Yang, Chang, Wen-Chang, Chen, Pin-Yuan, Chuang, Jian-Ying

“…Glioblastoma (GBM) is the most aggressive and lethal brain tumor. Although the histone deacetylase (HDAC)/transcription factor axis promotes growth in GBM,…”
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The S. pombe CDK5 Orthologue Pef1 Cooperates with Three Cyclins, Clg1, Pas1 and Psl1, to Promote Pre-Meiotic DNA Replication by Matsuda, Shinya, Kikkawa, Ushio, Nakashima, Akio

“…Meiosis is a specialized cell division process that mediates genetic information transfer to the next generation. Meiotic chromosomal segregation occurs when…”
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Versatile function of the circadian protein CIPC as a regulator of Erk activation by Matsunaga, Ryota, Nishino, Tasuku, Yokoyama, Atsushi, Nakashima, Akio, Kikkawa, Ushio, Konishi, Hiroaki

“…The CLOCK-interacting protein, Circadian (CIPC), has been identified as an additional negative-feedback regulator of the circadian clock. However, recent study…”
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Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1 by Ooi, Ee Lyn, Chan, Stephanie T., Cho, Noell E., Wilkins, Courtney, Woodward, Jessica, Li, Meng, Kikkawa, Ushio, Tellinghuisen, Timothy, Gale, Michael, Saito, Takeshi

“…In response to viral infection, the host induces over 300 IFN-stimulated genes (ISGs), which are the central component of intracellular antiviral innate…”
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Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex by Santiago Lima, Arthur Jorge, Hoogeveen-Westerveld, Marianne, Nakashima, Akio, Maat-Kievit, Anneke, van den Ouweland, Ans, Halley, Dicky, Kikkawa, Ushio, Nellist, Mark

“…The TSC1-TSC2-TBC1D7 complex is an important negative regulator of the mechanistic target of rapamycin complex 1 that controls cell growth in response to…”
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Proline dehydrogenase promotes senescence through the generation of reactive oxygen species by Nagano, Taiki, Nakashima, Akio, Onishi, Kengo, Kawai, Kosuke, Awai, Yuto, Kinugasa, Mizuki, Iwasaki, Tetsushi, Kikkawa, Ushio, Kamada, Shinji

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Cyclin I is involved in the regulation of cell cycle progression by Nagano, Taiki, Hashimoto, Toshiaki, Nakashima, Akio, Hisanaga, Shin-ichi, Kikkawa, Ushio, Kamada, Shinji

“…Cyclins control cell cycle progression by regulating the activity of cyclin-dependent kinases (Cdks). Cyclin I is a member of the cyclin family because of the…”
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Contribution of caspase(s) to the cell cycle regulation at mitotic phase by Hashimoto, Toshiaki, Kikkawa, Ushio, Kamada, Shinji

“…Caspases have been suggested to contribute to not only apoptosis regulation but also non-apoptotic cellular phenomena. Recently, we have reported the…”
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