Search Results - "Kikelj, Danijel"

Dual Inhibitors of Human DNA Topoisomerase II and Other Cancer-Related Targets by Skok, Žiga, Zidar, Nace, Kikelj, Danijel, Ilaš, Janez

“…Human DNA topoisomerase II is an important target in anticancer therapy. Despite the clinical success of drugs that target topoisomerase II, the development of…”
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ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents by Durcik, Martina, Tomašič, Tihomir, Zidar, Nace, Zega, Anamarija, Kikelj, Danijel, Mašič, Lucija Peterlin, Ilaš, Janez

“…The bacterial topoisomerases DNA gyrase and topoisomerase IV are validated targets for development of novel antibacterial agents. Fluoroquinolones inhibit the…”
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Rational design of balanced dual-targeting antibiotics with limited resistance by Nyerges, Akos, Tomašič, Tihomir, Durcik, Martina, Revesz, Tamas, Szili, Petra, Draskovits, Gabor, Bogar, Ferenc, Skok, Žiga, Zidar, Nace, Ilaš, Janez, Zega, Anamarija, Kikelj, Danijel, Daruka, Lejla, Kintses, Balint, Vasarhelyi, Balint, Foldesi, Imre, Kata, Diána, Welin, Martin, Kimbung, Raymond, Focht, Dorota, Mašič, Lucija Peterlin, Pal, Csaba

“…Antibiotics that inhibit multiple bacterial targets offer a promising therapeutic strategy against resistance evolution, but developing such antibiotics is…”
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Antibacterial and Antibiofilm Potentials of Marine Pyrrole-2-Aminoimidazole Alkaloids and their Synthetic Analogs by Gjorgjieva, Marina, Masic, Lucija Peterlin, Kikelj, Danijel

“…Pyrrole-2-aminoimidazole compounds are found in marine organisms, mainly as secondary metabolites in various marine sponges. Studies of natural…”
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Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells by Pišlar, Anja Hafner, Zidar, Nace, Kikelj, Danijel, Kos, Janko

“…The cysteine carboxypeptidase cathepsin X is an important player in degenerative processes under normal ageing and pathological conditions. In the present…”
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Isoform selective voltage-gated sodium channel modulators and the therapy of pain by Jukič, Marko, Kikelj, Danijel, Anderluh, Marko

“…Voltage-gated sodium channels are large transmembrane protein complexes responsible for the propagation and transmission of electrical impulses through nerve,…”
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2-Aminoimidazoles in medicinal chemistry by Žula, Aleš, Kikelj, Danijel, Ilaš, Janez

“…2-Aminoimidazole skeleton represents a unique building block which is often used in the design of modulators of different targets and small molecule drugs…”
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Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity by Žula, Aleš, Będziak, Izabela, Kikelj, Danijel, Ilaš, Janez

“…Spumigins are marine natural products derived from cyanobacteria , which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the…”
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Recent advances in the synthesis of 2H-1,4-benzoxazin-3-(4H)-ones and 3,4-dihydro-2H-1,4-benzoxazines by Ilaš, Janez, Anderluh, Petra Štefanič, Dolenc, Marija Sollner, Kikelj, Danijel

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The application of Freidinger lactams and their analogs in the design of conformationally constrained peptidomimetics by Perdih, Andrej, Kikelj, Danijel

“…Peptides exist in solution as an equilibrium mixture of conformers. The backbone conformational constraints are of interest as a means of limiting degrees of…”
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Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening by Rogers, Marc, Zidar, Nace, Kikelj, Danijel, Kirby, Robert W

“…The rodent neuroblastoma cell line, ND7-23, is used to express voltage-dependent sodium (Nav) and other neuronal ion channels resistant to heterologous…”
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Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation by Durcik, Martina, Skok, Žiga, Ilaš, Janez, Zidar, Nace, Zega, Anamarija, Szili, Petra Éva, Draskovits, Gábor, Révész, Tamás, Kikelj, Danijel, Nyerges, Akos, Pál, Csaba, Mašič, Lucija Peterlin, Tomašič, Tihomir

“…The discovery of multi-targeting ligands of bacterial enzymes is an important strategy to combat rapidly spreading antimicrobial resistance. Bacterial DNA…”
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Multitarget antithrombotic drugs by Ilić, Miloš, Kikelj, Danijel, Ilaš, Janez

“…Thromboembolic disorders are still the leading causes of morbidity and mortality in developed societies. Therefore, prophylaxis and treatment of arterial and…”
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Efficient Synthesis of Hydroxy-Substituted 2‑Aminobenzo[d]thiazole-6-carboxylic Acid Derivatives as New Building Blocks in Drug Discovery by Durcik, Martina, Toplak, Žan, Zidar, Nace, Ilaš, Janez, Zega, Anamarija, Kikelj, Danijel, Mašič, Lucija Peterlin, Tomašič, Tihomir

“…Benzo­[d]­thiazole is widely used in synthetic and medicinal chemistry, and it is a component of many compounds and drugs that have several different…”
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Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting d-Glu- and diphosphate-binding sites by Tomašić, Tihomir, Kovač, Andreja, Simčič, Mihael, Blanot, Didier, Grdadolnik, Simona Golič, Gobec, Stanislav, Kikelj, Danijel, Peterlin Mašič, Lucija

“…Mur ligases are involved in cytoplasmic steps of bacterial peptidoglycan biosynthesis and are viable targets for antibacterial drug discovery. We have designed…”
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Practical Synthesis and Application of Halogen-Doped Pyrrole Building Blocks by Cotman, Andrej Emanuel, Guérin, Thomas, Kovačević, Ivana, Benedetto Tiz, Davide, Durcik, Martina, Fulgheri, Federica, Možina, Štefan, Secci, Daniela, Sterle, Maša, Ilaš, Janez, Zega, Anamarija, Zidar, Nace, Mašič, Lucija Peterlin, Tomašič, Tihomir, Leroux, Frédéric R, Hanquet, Gilles, Kikelj, Danijel

“…A practical access to four new halogen-substituted pyrrole building blocks was realized in two to five synthetic steps from commercially available starting…”
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Novel Potent and Selective Thrombin Inhibitors Based on a Central 1,4-Benzoxazin-3(4H)-one Scaffold by Ilaš, Janez, Tomašić, Tihomir, Kikelj, Danijel

“…Novel thrombin inhibitors with the central 1,4-benzoxazine-3(4H)-one scaffold, benzamidine P1 arginine side chain mimetic and various P3 moieties are…”
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Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus by Tomašić, Tihomir, Šink, Roman, Zidar, Nace, Fic, Anja, Contreras-Martel, Carlos, Dessen, Andréa, Patin, Delphine, Blanot, Didier, Müller-Premru, Manica, Gobec, Stanislav, Zega, Anamarija, Kikelj, Danijel, Mašič, Lucija Peterlin

“…MurD and MurE ligases, consecutive enzymes participating in the intracellular steps of bacterial peptidoglycan biosynthesis, are important targets for…”
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Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase by Tomašić, Tihomir, Zidar, Nace, Rupnik, Veronika, Kovač, Andreja, Blanot, Didier, Gobec, Stanislav, Kikelj, Danijel, Mašič, Lucija Peterlin

“…Mur ligases catalyze the biosynthesis of the UDP-MurNAc-pentapeptide precursor of peptidoglycan, an essential polymer of bacterial cell-wall. They constitute…”
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Synthesis of ethyl 3-(hydroxyphenoxy)benzyl butylphosphonates as potential antigen 85C inhibitors by Frlan, Rok, Gobec, Stanislav, Kikelj, Danijel

“…All three isomers of ethyl 3-(hydroxyphenoxy)benzyl butylphosphonates as potential antigen 85C inhibitors were synthesized from 3-bromobenzoic acid using…”
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