Search Results - "Kijima, Aki"

Mechanisms Underlying Exacerbation of Osmotic Nephrosis Caused by Pre-existing Kidney Injury by Matsushita, Kohei, Takasu, Shinji, Kuroda, Ken, Ishii, Yuji, Kijima, Aki, Ogawa, Kumiko, Umemura, Takashi

“…Abstract Osmotic nephrosis, a disease caused by intravenous infusion of various fluids such as hypertonic sucrose and isotonic polysaccharide-based plasma…”
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Effects of inhibition of hepatic sulfotransferase activity on renal genotoxicity induced by lucidin‐3‐O‐primeveroside by Ishii, Yuji, Kijima, Aki, Takasu, Shinji, Ogawa, Kumiko, Umemura, Takashi

“…Sulfotransferase 1A (SULT1A) expression is lower in the liver of humans than that of rodents. Therefore, species differences should be taken into consideration…”
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Background data of 2-year-old male and female F344 gpt delta rats by Matsushita, Kohei, Ishii, Yuji, Kijima, Aki, Takasu, Shinji, Kuroda, Ken, Takagi, Hisayoshi, Nohmi, Takehiko, Ogawa, Kumiko, Umemura, Takashi

“…Although gpt delta rats, as reporter gene-transgenic rats, were originally developed for in vivo mutation assays, they have also been used to evaluate chemical…”
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Molecular Pathological Differences in Global Gene Expression between Two Sustained Proliferative Lesions, Nodular Regenerative Hepatocellular Hyperplasia and Hepatocellular Adenoma, in Mice by Takasu, Shinji, Yokoo, Yuh, Ishii, Yuji, Kijima, Aki, Ogawa, Kumiko, Umemura, Takashi

“…Long-term exposure to piperonyl butoxide (PBO) induces multiple nodular masses along with hepatocellular tumors in the liver of mice. The histopathological…”
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Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin by Tsuchiya, Takuma, Kijima, Aki, Ishii, Yuji, Takasu, Shinji, Yokoo, Yuh, Nishikawa, Akiyoshi, Yanai, Tokuma, Umemura, Takashi

“…Oxidative stress is well known as a key factor of chemical carcinogenesis. However, the actual role of oxidative stress in carcinogenesis, such as oxidative…”
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Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression by Hibi, Daisuke, Kijima, Aki, Kuroda, Ken, Suzuki, Yuta, Ishii, Yuji, Jin, Meilan, Nakajima, Masahiro, Sugita-Konishi, Yoshiko, Yanai, Tokuma, Nohmi, Takehiko, Nishikawa, Akiyoshi, Umemura, Takashi

“…Ochratoxin A (OTA) is a renal carcinogen primarily affecting the S3 segment of proximal tubules in rodents. In our previous study, we reported that OTA induces…”
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Lack of genotoxic mechanisms in early‐stage furan‐induced hepatocellular tumorigenesis in gpt delta rats by Hibi, Daisuke, Yokoo, Yu, Suzuki, Yuta, Ishii, Yuji, Jin, Meilan, Kijima, Aki, Nohmi, Takehiko, Nishikawa, Akiyoshi, Umemura, Takashi

“…Furan has been used as an intermediate in the chemical‐manufacturing industry and has been shown to contaminate various foods. Although furan induces…”
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Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice by Kuroda, Ken, Hibi, Daisuke, Ishii, Yuji, Yokoo, Yuh, Takasu, Shinji, Kijima, Aki, Matsushita, Kohei, Masumura, Ken-ichi, Kodama, Yukio, Yanai, Tokuma, Sakai, Hiroki, Nohmi, Takehiko, Ogawa, Kumiko, Umemura, Takashi

“…Carcinogenic doses of ochratoxin A (OTA) cause increases of mutant frequencies (MFs) of the red/gam gene (Spi(-)) in the kidneys of p53-deficient gpt delta…”
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Role of oxidative stress in the chemical structure-related genotoxicity of nitrofurantoin in Nrf2-deficient gpt delta mice by Tsuchiya, Takuma, Kijima, Aki, Ishii, Yuji, Takasu, Shinji, Yokoo, Yuh, Nishikawa, Akiyoshi, Yanai, Tokuma, Umemura, Takashi

“…Despite its antimicrobial activity, nitrofurantoin (NFT) is a renal carcinogen in rats. Oxidative stress induced by reduction of the nitro group of NFT may…”
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Chemical structure-related mechanisms underlying in vivo genotoxicity induced by nitrofurantoin and its constituent moieties in gpt delta rats by Kijima, Aki, Ishii, Yuji, Takasu, Shinji, Matsushita, Kohei, Kuroda, Ken, Hibi, Daisuke, Suzuki, Yuta, Nohmi, Takehiko, Umemura, Takashi

“…Nitrofurans are antimicrobial compounds containing a nitro group at the 5-position of the furan ring and an amine or hydrazide side chain derivative. One…”
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Effects of Nrf2 silencing on oxidative stress‐associated intestinal carcinogenesis in mice by Yokoo, Yuh, Kijima, Aki, Ishii, Yuji, Takasu, Shinji, Tsuchiya, Takuma, Umemura, Takashi

“…To assess the risk of colorectal cancer in humans with inactivation of NRF2, Nrf2‐proficient (Nrf2+/+) and ‐deficient (Nrf2−/−) mice were exposed to potassium…”
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Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53 -deficient gpt delta mice by Hibi, Daisuke, Kijima, Aki, Suzuki, Yuta, Ishii, Yuji, Jin, Meilan, Sugita-Konishi, Yoshiko, Yanai, Tokuma, Nishikawa, Akiyoshi, Umemura, Takashi

“…Highlights ► OTA raised Spi− mutant frequency in the kidneys of p53 -deficient gpt delta mice. ► OTA induced significant increase of p53 protein levels in the…”
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Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats by Kuroda, Ken, Hibi, Daisuke, Ishii, Yuji, Takasu, Shinji, Kijima, Aki, Matsushita, Kohei, Masumura, Ken-Ichi, Watanabe, Maiko, Sugita-Konishi, Yoshiko, Sakai, Hiroki, Yanai, Tokuma, Nohmi, Takehiko, Ogawa, Kumiko, Umemura, Takashi

“…Ochratoxin A (OTA) is a carcinogen targeting proximal tubules at the renal outer medulla (ROM) in rodents. We previously reported that OTA increased mutant…”
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Combined application of comprehensive analysis for DNA modification and reporter gene mutation assay to evaluate kidneys of gpt delta rats given madder color or its constituents by Ishii, Yuji, Takasu, Shinji, Kuroda, Ken, Matsushita, Kohei, Kijima, Aki, Nohmi, Takehiko, Ogawa, Kumiko, Umemura, Takashi

“…DNA adductome analysis using liquid chromatography–tandem mass spectrometry is a promising tool to exhaustively search DNA modifications. Given that the…”
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In vivo genotoxicity of Ginkgo biloba extract in gpt delta mice and constitutive androstane receptor knockout mice by Maeda, Jun, Kijima, Aki, Inoue, Kaoru, Ishii, Yuji, Ichimura, Ryohei, Takasu, Shinji, Kuroda, Ken, Matsushita, Kohei, Kodama, Yukio, Saito, Naoaki, Umemura, Takashi, Yoshida, Midori

“…The National Toxicology Program study of Ginkgo biloba extract (GBE), a herbal supplement, reported concerns regarding genotoxicity and clear evidence of…”
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In vivo genotoxicity of methyleugenol in gpt delta transgenic rats following medium-term exposure by Jin, Meilan, Kijima, Aki, Hibi, Daisuke, Ishii, Yuji, Takasu, Shinji, Matsushita, Kohei, Kuroda, Ken, Nohmi, Takehiko, Nishikawa, Akiyoshi, Umemura, Takasi

“…Methyleugenol (MEG), which is commonly used as a fragrance and flavoring agent, has been shown to induce hepatocellular tumors in rodents. However, the role of…”
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Lack of nrf2 results in progression of proliferative lesions to neoplasms induced by long-term exposure to non-genotoxic hepatocarcinogens involving oxidative stress by Tasaki, Masako, Kuroiwa, Yuichi, Inoue, Tomoki, Hibi, Daisuke, Matsushita, Kohei, Kijima, Aki, Maruyama, Soichi, Nishikawa, Akiyoshi, Umemura, Takashi

“…To explore the role of oxidative stress in chemical carcinogenesis driven by non-genotoxic mechanisms, nrf2-deficient (nrf2−/−) and nrf2-wild-type (nrf2+/+)…”
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Development of a Medium-term Animal Model Using gpt Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity by Matsushita, Kohei, Kijima, Aki, Ishii, Yuji, Takasu, Shinji, Jin, Meilan, Kuroda, Ken, Kawaguchi, Hiroaki, Miyoshi, Noriaki, Nohmi, Takehiko, Ogawa, Kumiko, Umemura, Takashi

“…In this study, the potential for development of an animal model (GPG46) capable of rapidly detecting chemical carcinogenicity and the underlying mechanisms of…”
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Acrylamide induces specific DNA adduct formation and gene mutations in a carcinogenic target site, the mouse lung by Ishii, Yuji, Matsushita, Kohei, Kuroda, Ken, Yokoo, Yuh, Kijima, Aki, Takasu, Shinji, Kodama, Yukio, Nishikawa, Akiyoshi, Umemura, Takashi

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In vivo genotoxicity of 1-methylnaphthalene from comprehensive toxicity studies with B6C3F1 gpt delta mice by Jin, Meilan, Kijima, Aki, Suzuki, Yuta, Hibi, Daisuke, Ishii, Yuji, Nohmi, Takehiko, Nishikawa, Akiyoshi, Ogawa, Kumiko, Umemura, Takashi

“…1-Methylnaphthalene (1-MN), a constituent of the polycyclic aromatic hydrocarbons (PAHs), is a lung carcinogen in mice. However, conventional genotoxicity…”
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