Synthesis of Acyl Derivatives of Prolyl-leucinamides
Synthetic routes to prolyl-leucinamide, N -benzyl(prolyl)leucinamide, and N -(prolyl-leucyl)morpholine were proposed. Treatment of these compounds with benzoyl chloride or acetyl chloride in the presence of triethylamine afforded the corresponding ( N -acylprolyl)leucinamides. Acyl derivatives of N...
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Published in: | Russian journal of organic chemistry Vol. 56; no. 1; pp. 82 - 89 |
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Main Authors: | , , , |
Format: | Journal Article |
Language: | English |
Published: |
Moscow
Pleiades Publishing
2020
Springer Nature B.V |
Subjects: | |
Online Access: | Get full text |
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Summary: | Synthetic routes to prolyl-leucinamide,
N
-benzyl(prolyl)leucinamide, and
N
-(prolyl-leucyl)morpholine were proposed. Treatment of these compounds with benzoyl chloride or acetyl chloride in the presence of triethylamine afforded the corresponding (
N
-acylprolyl)leucinamides. Acyl derivatives of
N
-benzyl(prolyl)-leucinamide, and
N
-(prolyl-leucyl)morpholine were also synthesized by condensation of (
N
-benzoylprolyl)-leucine or (
N
-acetylprolyl)leucine with benzylamine or morpholine in the presence of
N, N
′-dicyclohexyl-carbodiimide. |
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ISSN: | 1070-4280 1608-3393 |
DOI: | 10.1134/S1070428020010145 |