Synthesis of Acyl Derivatives of Prolyl-leucinamides

Synthetic routes to prolyl-leucinamide, N -benzyl(prolyl)leucinamide, and N -(prolyl-leucyl)morpholine were proposed. Treatment of these compounds with benzoyl chloride or acetyl chloride in the presence of triethylamine afforded the corresponding ( N -acylprolyl)leucinamides. Acyl derivatives of N...

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Bibliographic Details
Published in:Russian journal of organic chemistry Vol. 56; no. 1; pp. 82 - 89
Main Authors: Haidukevich, V. A., Kievitskaya, D. V., Popova, L. A., Knizhnikov, V. A.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 2020
Springer Nature B.V
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Summary:Synthetic routes to prolyl-leucinamide, N -benzyl(prolyl)leucinamide, and N -(prolyl-leucyl)morpholine were proposed. Treatment of these compounds with benzoyl chloride or acetyl chloride in the presence of triethylamine afforded the corresponding ( N -acylprolyl)leucinamides. Acyl derivatives of N -benzyl(prolyl)-leucinamide, and N -(prolyl-leucyl)morpholine were also synthesized by condensation of ( N -benzoylprolyl)-leucine or ( N -acetylprolyl)leucine with benzylamine or morpholine in the presence of N, N ′-dicyclohexyl-carbodiimide.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428020010145