Search Results - "Kieser, Arnd"

Pursuing different 'TRADDes': TRADD signaling induced by TNF-receptor 1 and the Epstein-Barr virus oncoprotein LMP1 by Kieser, Arnd

“…The pro-apoptotic tumor necrosis factor (TNF)-receptor 1-associated death domain protein (TRADD) was initially identified as the central signaling adapter…”
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A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation by Voigt, Stefanie, Sterz, Kai R., Giehler, Fabian, Mohr, Anne-Wiebe, Wilson, Joanna B., Moosmann, Andreas, Kieser, Arnd

“…IκB kinase 2 (IKK2) is well known for its pivotal role as a mediator of the canonical NF-κB pathway, which has important functions in inflammation and…”
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Expression of the vault RNA protects cells from undergoing apoptosis by Amort, Melanie, Nachbauer, Birgit, Tuzlak, Selma, Kieser, Arnd, Schepers, Aloys, Villunger, Andreas, Polacek, Norbert

“…Non-protein-coding RNAs are a functionally versatile class of transcripts exerting their biological roles on the RNA level. Recently, we demonstrated that the…”
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Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex by Giehler, Fabian, Ostertag, Michael S., Sommermann, Thomas, Weidl, Daniel, Sterz, Kai R., Kutz, Helmut, Moosmann, Andreas, Feller, Stephan M., Geerlof, Arie, Biesinger, Brigitte, Popowicz, Grzegorz M., Kirchmair, Johannes, Kieser, Arnd

“…Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) drives viral B cell transformation and oncogenesis. LMP1’s transforming activity depends on its…”
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The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor by Shkoda, Anna, Town, Jennifer A, Griese, Janine, Romio, Michael, Sarioglu, Hakan, Knöfel, Thomas, Giehler, Fabian, Kieser, Arnd

“…The tumor necrosis factor-receptor-associated factor 2 (TRAF2)- and Nck-interacting kinase (TNIK) is a ubiquitously expressed member of the germinal center…”
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Discovery of Small Molecule CD40–TRAF6 Inhibitors by Zarzycka, Barbara, Seijkens, Tom, Nabuurs, Sander B, Ritschel, Tina, Grommes, Jochen, Soehnlein, Oliver, Schrijver, Roy, van Tiel, Claudia M, Hackeng, Tilman M, Weber, Christian, Giehler, Fabian, Kieser, Arnd, Lutgens, Esther, Vriend, Gert, Nicolaes, Gerry A. F

“…The CD154–CD40 receptor complex plays a pivotal role in several inflammatory pathways. Attempts to inhibit the formation of this complex have resulted in…”
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A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release by Sauter, Daniel, Hotter, Dominik, Engelhart, Susanne, Giehler, Fabian, Kieser, Arnd, Kubisch, Christian, Kirchhoff, Frank

“…Tetherin (or BST-2) is an antiviral host restriction factor that suppresses the release of HIV-1 and other enveloped viruses by tethering them to the cell…”
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Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis by van Os, Bram W, Kusters, Pascal J H, den Toom, Myrthe, Beckers, Linda, van Tiel, Claudia M, Vos, Winnie G, de Jong, Elize, Kieser, Arnd, van Roomen, Cindy, Binder, Christoph J, Reiche, Myrthe E, de Winther, Menno P, Bosmans, Laura A, Lutgens, Esther

“…Atherosclerosis is the underlying cause of many cardiovascular diseases, such as myocardial infarction or stroke. B cells, and their production of pro- and…”
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Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis by DIRMEIER, Ulrike, HOFFMANN, Reinhard, KILGER, Ellen, SCHULTHEISS, Ute, BRISENO, Cinthia, GIRES, Olivier, KIESER, Arnd, EICK, Dirk, SUGDEN, Bill, HAMMERSCHMIDT, Wolfgang

“…Latent membrane protein 1 (LMP1), an oncoprotein encoded by Epstein-Barr virus (EBV), is an integral membrane protein, which acts like a constitutively active…”
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The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity by Schneider, Frank, Neugebauer, Julia, Griese, Janine, Liefold, Nicola, Kutz, Helmut, Briseño, Cinthia, Kieser, Arnd

“…The tumor necrosis factor (TNF)-receptor 1-associated death domain protein (TRADD) mediates induction of apoptosis as well as activation of NF-kappaB by…”
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Activation of Mitogen-Activated Protein Kinase and NF-κB Pathways by a Kaposi's Sarcoma-Associated Herpesvirus K15 Membrane Protein by Brinkmann, Melanie M., Glenn, Mark, Rainbow, Lucille, Kieser, Arnd, Henke-Gendo, Cornelia, Schulz, Thomas F.

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein–Barr virus by Kutz, Helmut, Reisbach, Gilbert, Schultheiss, Ute, Kieser, Arnd

“…Abstract The latent membrane protein 1 (LMP1) of Epstein–Barr virus (EBV) transforms cells activating signal transduction pathways such as NF-κB, PI3-kinase,…”
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LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2 by Kieser, Arnd, Kaiser, Christian, Hammerschmidt, Wolfgang

“…The Epstein–Barr virus latent membrane protein 1 (LMP1) binds tumor necrosis factor receptor (TNFR)‐associated factors (TRAFs) and the TNFR‐associated death…”
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Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas by Schrader, Alexandra, Meyer, Katharina, von Bonin, Frederike, Vockerodt, Martina, Walther, Neele, Hand, Elisabeth, Ulrich, Antje, Matulewicz, Kamila, Lenze, Dido, Hummel, Michael, Kieser, Arnd, Engelke, Michael, Trümper, Lorenz, Kube, Dieter

“…Aggressive Non-Hodgkin lymphomas (NHL) are a group of lymphomas derived from germinal centre B cells which display a heterogeneous pattern of oncogenic pathway…”
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Latent Membrane Protein 1 of Epstein-Barr Virus Induces CD83 by the NF-κB Signaling Pathway by Dudziak, Diana, Kieser, Arnd, Dirmeier, Ulrike, Nimmerjahn, Falk, Berchtold, Susanne, Steinkasserer, Alexander, Marschall, Gabriele, Hammerschmidt, Wolfgang, Laux, Gerhard, Bornkamm, Georg W.

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Latent Membrane Protein 1 (LMP1) by Kieser, Arnd, Sterz, Kai R

“…Almost exactly twenty years after the discovery of Epstein-Barr virus (EBV), the latent membrane protein 1 (LMP1) entered the EBV stage, and soon thereafter,…”
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Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis by Kolch, W, Martiny-Baron, G, Kieser, A, Marmé, D

“…Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPS) plays a crucial role for the vascularization of tumors including breast cancers…”
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Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology by Entschladen, Frank, Altschmied, Joachim, Baumgrass, Ria, Behrmann, Iris, Giehl, Klaudia, Hermanns, Heike, Huber, Otmar, Kieser, Arnd, Klotz, Lars-Oliver, Kubatzky, Katharina F, Hass, Ralf, Janssen, Ottmar, Friedrich, Karlheinz

“…The 13th meeting of the Signal Transduction Society was held in Weimar, from October 28 to 30, 2009. Special focus of the 2009 conference was "Aging and…”
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Activated Raf Induces the Hyperphosphorylation of Stathmin and the Reorganization of the Microtubule Network by Lovrić, Josip, Dammeier, Sascha, Kieser, Arnd, Mischak, Harald, Kolch, Walter

“…Raf kinases are regulators of cellular proliferation, transformation, differentiation, and apoptosis. To identify downstream targets of Raf-1 in vivo, we used…”
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Quantitative modeling of signaling in aggressive B cell lymphoma unveils conserved core network by Klinger, Bertram, Rausch, Isabel, Sieber, Anja, Kutz, Helmut, Kruse, Vanessa, Kirchner, Marieluise, Mertins, Philipp, Kieser, Arnd, Blüthgen, Nils, Kube, Dieter

“…B cell receptor (BCR) signaling is required for the survival and maturation of B cells and is deregulated in B cell lymphomas. While proximal BCR signaling is…”
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