Search Results - "Kieran, Mark W."

Resolvins suppress tumor growth and enhance cancer therapy by Sulciner, Megan L, Serhan, Charles N, Gilligan, Molly M, Mudge, Dayna K, Chang, Jaimie, Gartung, Allison, Lehner, Kristen A, Bielenberg, Diane R, Schmidt, Birgitta, Dalli, Jesmond, Greene, Emily R, Gus-Brautbar, Yael, Piwowarski, Julia, Mammoto, Tadanori, Zurakowski, David, Perretti, Mauro, Sukhatme, Vikas P, Kaipainen, Arja, Kieran, Mark W, Huang, Sui, Panigrahy, Dipak

“…Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth…”
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Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor by Gartung, Allison, Yang, Jun, Sukhatme, Vikas P., Bielenberg, Diane R., Fernandes, Djanira, Chang, Jaimie, Schmidt, Birgitta A., Hwang, Sung Hee, Zurakowski, David, Huang, Sui, Kieran, Mark W., Hammock, Bruce D., Panigrahy, Dipak

“…Although chemotherapy is a conventional cancer treatment, it may induce a protumorigenic microenvironment by triggering the release of proinflammatory…”
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Role of Collagen Matrix in Tumor Angiogenesis and Glioblastoma Multiforme Progression by Mammoto, Tadanori, Jiang, Amanda, Jiang, Elisabeth, Panigrahy, Dipak, Kieran, Mark W, Mammoto, Akiko

“…Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its progression-free survival. However, current antiangiogenic therapy…”
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Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases by Panigrahy, Dipak, Gartung, Allison, Yang, Jun, Yang, Haixia, Gilligan, Molly M, Sulciner, Megan L, Bhasin, Swati S, Bielenberg, Diane R, Chang, Jaimie, Schmidt, Birgitta A, Piwowarski, Julia, Fishbein, Anna, Soler-Ferran, Dulce, Sparks, Matthew A, Staffa, Steven J, Sukhatme, Vidula, Hammock, Bruce D, Kieran, Mark W, Huang, Sui, Bhasin, Manoj, Serhan, Charles N, Sukhatme, Vikas P

“…Cancer therapy is a double-edged sword, as surgery and chemotherapy can induce an inflammatory/immunosuppressive injury response that promotes dormancy escape…”
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Identification of fibroblast heterogeneity in the tumor microenvironment by Sugimoto, Hikaru, Mundel, Thomas M, Kieran, Mark W., Kalluri, Raghu

“…Tumors are unorganized organs that contain many different cell types. In the recent years, many studies have reported that primary tumors contain…”
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Pediatric high-grade glioma: biologically and clinically in need of new thinking by Jones, Chris, Karajannis, Matthias A, Jones, David T W, Kieran, Mark W, Monje, Michelle, Baker, Suzanne J, Becher, Oren J, Cho, Yoon-Jae, Gupta, Nalin, Hawkins, Cynthia, Hargrave, Darren, Haas-Kogan, Daphne A, Jabado, Nada, Li, Xiao-Nan, Mueller, Sabine, Nicolaides, Theo, Packer, Roger J, Persson, Anders I, Phillips, Joanna J, Simonds, Erin F, Stafford, James M, Tang, Yujie, Pfister, Stefan M, Weiss, William A

“…High-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed…”
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Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis by Zhang, Guodong, Panigrahy, Dipak, Mahakian, Lisa M., Yang, Jun, Liu, Jun-Yan, Lee, Kin Sing Stephen, Wettersten, Hiromi I., Ulu, Arzu, Hu, Xiaowen, Tam, Sarah, Hwang, Sung Hee, Ingham, Elizabeth S., Kieran, Mark W., Weiss, Robert H., Ferrara, Katherine W., Hammock, Bruce D.

“…Epidemiological and preclinical evidence supports that omega-3 dietary fatty acids (fish oil) reduce the risks of macular degeneration and cancers, but the…”
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Impact of Farnesylation Inhibitors on Survival in Hutchinson-Gilford Progeria Syndrome by GORDON, Leslie B, MASSARO, Joe, D'AGOSTINO, Ralph B, CAMPBELL, Susan E, BRAZIER, Joan, BROWN, W. Ted, KLEINMAN, Monica E, KIERAN, Mark W

“…Hutchinson-Gilford progeria syndrome is an ultrarare segmental premature aging disease resulting in early death from heart attack or stroke. There is no…”
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Clinical and treatment factors determining long‐term outcomes for adult survivors of childhood low‐grade glioma: A population‐based study by Krishnatry, Rahul, Zhukova, Nataliya, Guerreiro Stucklin, Ana S., Pole, Jason D., Mistry, Matthew, Fried, Iris, Ramaswamy, Vijay, Bartels, Ute, Huang, Annie, Laperriere, Normand, Dirks, Peter, Nathan, Paul C., Greenberg, Mark, Malkin, David, Hawkins, Cynthia, Bandopadhayay, Pratiti, Kieran, Mark W., Manley, Peter E., Bouffet, Eric, Tabori, Uri

“…BACKGROUND The determinants of outcomes for adult survivors of pediatric low‐grade glioma (PLGG) are largely unknown. METHODS This study collected…”
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Adjunct Targeted Biologic Inhibition Agents to Treat Aggressive Multivessel Intraluminal Pediatric Pulmonary Vein Stenosis by Callahan, Ryan, Kieran, Mark W., Baird, Christopher W., Colan, Steven D., Gauvreau, Kimberlee, Ireland, Christina M., Marshall, Audrey C., Sena, Laureen M., Vargas, Sara O., Jenkins, Kathy J.

“…To evaluate the use of imatinib mesylate with or without bevacizumab targeting neoproliferative myofibroblast-like cells with tyrosine kinase receptor…”
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Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson–Gilford progeria syndrome by Gordon, Leslie B, Kleinman, Monica E, Miller, David T, Neuberg, Donna S, Giobbie-Hurder, Anita, Gerhard-Herman, Marie, Smoot, Leslie B, Gordon, Catherine M, Cleveland, Robert, Snyder, Brian D, Fligor, Brian, Bishop, W. Robert, Statkevich, Paul, Regen, Amy, Sonis, Andrew, Riley, Susan, Ploski, Christine, Correia, Annette, Quinn, Nicolle, Ullrich, Nicole J, Nazarian, Ara, Liang, Marilyn G, Huh, Susanna Y, Schwartzman, Armin, Kieran, Mark W

“…Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, fatal, segmental premature aging syndrome caused by a mutation in LMNA that produces the…”
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Platelets actively sequester angiogenesis regulators by Lakka Klement, Giannoula, Yip, Tai-Tung, Cassiola, Flavia, Kikuchi, Lena, Cervi, David, Podust, Vladimir, Italiano, Joseph E., Wheatley, Erin, Abou-Slaybi, Abdo, Bender, Elise, Almog, Nava, Kieran, Mark W., Folkman, Judah

“…Clinical trials with antiangiogenic agents have not been able to validate plasma or serum levels of angiogenesis regulators as reliable markers of cancer…”
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Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells by Reitman, Zachary J., Paolella, Brenton R., Bergthold, Guillaume, Pelton, Kristine, Becker, Sarah, Jones, Robert, Sinai, Claire E., Malkin, Hayley, Huang, Ying, Grimmet, Leslie, Herbert, Zachary T., Sun, Yu, Weatherbee, Jessica L., Alberta, John A., Daley, John F., Rozenblatt-Rosen, Orit, Condurat, Alexandra L., Qian, Kenin, Khadka, Prasidda, Segal, Rosalind A., Haas-Kogan, Daphne, Filbin, Mariella G., Suva, Mario L., Regev, Aviv, Stiles, Charles D., Kieran, Mark W., Goumnerova, Liliana, Ligon, Keith L., Shalek, Alex K., Bandopadhayay, Pratiti, Beroukhim, Rameen

“…Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement. Here, we perform scRNAseq in…”
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Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival by Marinoff, Amanda E., Ma, Clement, Guo, Dongjing, Snuderl, Matija, Wright, Karen D., Manley, Peter E., Al-Sayegh, Hasan, Sinai, Claire E., Ullrich, Nicole J., Marcus, Karen, Haas-Kogan, Daphne, Goumnerova, Liliana, London, Wendy B., Kieran, Mark W., Chi, Susan N., Fangusaro, Jason, Bandopadhayay, Pratiti

“…Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the…”
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The Integration of Biology Into the Treatment of Diffuse Intrinsic Pontine Glioma: A Review of the North American Clinical Trial Perspective by Clymer, Jessica, Kieran, Mark W

“…Dramatic advances in the molecular analysis of diffuse intrinsic pontine glioma have occurred over the last decade and resulted in the identification of…”
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Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas by Bechet, Denise, Gielen, Gerrit G. H., Korshunov, Andrey, Pfister, Stefan M., Rousso, Caterina, Faury, Damien, Fiset, Pierre-Olivier, Benlimane, Naciba, Lewis, Peter W., Lu, Chao, David Allis, C., Kieran, Mark W., Ligon, Keith L., Pietsch, Torsten, Ellezam, Benjamin, Albrecht, Steffen, Jabado, Nada

“…Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in…”
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Intensive Multimodality Treatment for Children With Newly Diagnosed CNS Atypical Teratoid Rhabdoid Tumor by CHI, Susan N, ZIMMERMAN, Mary Ann, GOLDMAN, Stewart, MANLEY, Peter E, BOWERS, Daniel C, BENDEL, Anne, RUBIN, Joshua, TURNER, Christopher D, MARCUS, Karen J, GOUMNEROVA, Liliana, ULLRICH, Nicole J, KIERAN, Mark W, XIAOPAN YAO, COHEN, Kenneth J, BURGER, Peter, BIEGEL, Jaclyn A, RORKE-ADAMS, Lucy B, FISHER, Michael J, JANSS, Anna, MAZEWSKI, Claire

“…Atypical teratoid rhabdoid tumor (ATRT) of the CNS is a highly malignant neoplasm primarily affecting young children, with a historic median survival ranging…”
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Future Clinical Trials in DIPG: Bringing Epigenetics to the Clinic by Morales La Madrid, Andres, Hashizume, Rintaro, Kieran, Mark W

“…In spite of major recent advances in diffuse intrinsic pontine glioma (DIPG) molecular characterization, this body of knowledge has not yet translated into…”
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Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis by Zhang, Guodong, Panigrahy, Dipak, Hwang, Sung Hee, Yang, Jun, Mahakian, Lisa M., Wettersten, Hiromi I., Liu, Jun-Yan, Wang, Yanru, Ingham, Elizabeth S., Tam, Sarah, Kieran, Mark W., Weiss, Robert H., Ferrara, Katherine W., Hammock, Bruce D.

“…Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH)…”
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Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma by Grill, Jacques, Puget, Stephanie, Andreiuolo, Felipe, Philippe, Cathy, MacConaill, Laura, Kieran, Mark W.

“…Diffuse intrinsic pontine gliomas (DIPG) can not be cured with current treatment modalities. Targeted therapy in this disease would benefit from advanced…”
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