Search Results - "Kienitz, Marie‐Cécile"

Angiotensin receptors and α1B-adrenergic receptors regulate native IK(ACh) and phosphorylation-deficient GIRK4 (S418A) channels through different PKC isoforms by Inderwiedenstraße, Leonie, Kienitz, Marie-Cécile

“…Signaling of G protein-activated inwardly rectifying K + (GIRK) channels is an important mechanism of the parasympathetic regulation of the heart rate and…”
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CRISPR/Cas9 Genome Editing in LGMD2A/R1 Patient-Derived Induced Pluripotent Stem and Skeletal Muscle Progenitor Cells by Mavrommatis, Lampros, Zaben, Abdul, Kindler, Urs, Kienitz, Marie-Cécile, Dietz, Julienne, Jeong, Hyun-Woo, Böhme, Pierre, Brand-Saberi, Beate, Vorgerd, Matthias, Zaehres, Holm

“…Large numbers of Calpain 3 (CAPN3) mutations cause recessive forms of limb-girdle muscular dystrophy (LGMD2A/LGMDR1) with selective atrophy of the proximal…”
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NCI-H295R cell line as in vitro model of hyperaldosteronism lacks functional KCNJ5 (GIRK4; Kir3.4) channels by Kienitz, Marie-Cécile, Mergia, Evanthia, Pott, Lutz

“…•We investigated basal and G protein-activated GIRK4 currents in H295R cells.•GIRK4 protein can be detected in Western blots of H295R homogenates.•GTP-γ-S did…”
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Familial Sinus Node Disease Caused by a Gain of GIRK (G-Protein Activated Inwardly Rectifying K + Channel) Channel Function by Kuß, Johanna, Stallmeyer, Birgit, Goldstein, Matthias, Rinné, Susanne, Pees, Christiane, Zumhagen, Sven, Seebohm, Guiscard, Decher, Niels, Pott, Lutz, Kienitz, Marie-Cécile, Schulze-Bahr, Eric

“…Inherited forms of sinus node dysfunction (SND) clinically include bradycardia, sinus arrest, and chronotropic incompetence and may serve as disease models to…”
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A genetically encoded tool kit for manipulating and monitoring membrane phosphatidylinositol 4,5-bisphosphate in intact cells by Hertel, Fabian, Switalski, Agathe, Mintert-Jancke, Elisa, Karavassilidou, Katharina, Bender, Kirsten, Pott, Lutz, Kienitz, Marie-Cécile

“…Most ion channels are regulated by phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) in the cell membrane by diverse mechanisms. Important molecular…”
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A role for RGS10 in β‐adrenergic modulation of G‐protein‐activated K+ (GIRK) channel current in rat atrial myocytes by Bender, Kirsten, Nasrollahzadeh, Parastoo, Timpert, Mathias, Liu, Bing, Pott, Lutz, Kienitz, Marie‐Cécile

“…The effect of β‐adrenergic stimulation on endogenous G‐protein‐activated K+ (GIRK) current has been investigated in atrial myocytes from hearts of adult rats…”
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Altered stress stimulation of inward rectifier potassium channels in Andersen‐Tawil syndrome by Seebohm, Guiscard, Strutz‐Seebohm, Nathalie, Ursu, Oana N., Preisig‐Müller, Regina, Zuzarte, Marylou, Hill, Elaine V., Kienitz, Marie‐Cécile, Bendahhou, Said, Fauler, Michael, Tapken, Daniel, Decher, Niels, Collins, Anthony, Jurkat‐Rott, Karin, Steinmeyer, Klaus, Lehmann‐Horn, Frank, Daut, Jürgen, Tavaré, Jeremy M., Pott, Lutz, Bloch, Wilhelm, Lang, Florian

“…ABSTRACT Inward rectifier potassium channels of the Kir2 subfamily are important determinants of the electrical activity of brain and muscle cells. Genetic…”
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Voltage-dependent open-channel block of G protein-gated inward-rectifying K+ (GIRK) current in rat atrial myocytes by tamoxifen by Vanheiden, Svenja, Pott, Lutz, Kienitz, Marie-Cécile

“…Tamoxifen (Tmx) is a nonsteroidal selective estrogen receptor antagonist and is frequently used in the treatment and prevention of breast cancer. The compound…”
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Generation of a constitutive Na+-dependent inward-rectifier current in rat adult atrial myocytes by overexpression of Kir3.4 by Mintert, Elisa, Bösche, Leif I., Rinne, Andreas, Timpert, Mathias, Kienitz, Marie‐Cécile, Pott, Lutz, Bender, Kirsten

“…Apart from gating by interaction with βγ subunits from heterotrimeric G proteins upon stimulation of appropriate receptors, Kir.3 channels have been shown to…”
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Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors by Kienitz, Marie-Cécile, Vladimirova, Dilyana, Müller, Christian, Pott, Lutz, Rinne, Andreas

“…Activation of Gq protein-coupled receptors (GqPCRs) might induce divergent cellular responses, related to receptor-specific activation of different branches of…”
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G Protein-Activated (GIRK) Current in Rat Ventricular Myocytes is Masked by Constitutive Inward Rectifier Current (IK1) by Beckmann, Christian, Rinne, Andreas, Littwitz, Christoph, Mintert, Elisa, Bösche, Leif I., Kienitz, Marie-Cécile, Pott, Lutz, Bender, Kirsten

“…Inwardly-rectifying K + channel subunits are not homogenously expressed in different cardiac tissues. In ventricular myocytes (VM) the background…”
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Synergistic modulation of KCNQ1/KCNE1 K(+) channels (IKs) by phosphatidylinositol 4,5-bisphosphate (PIP2) and [ATP]i by Kienitz, Marie-Cécile, Vladimirova, Dilyana

“…Cardiac KCNQ1/KCNE1 channels (IKs) are dependent on the concentration of membrane phosphatidylinositol-4,5-bisphosphate (PIP2) and on cytosolic ATP by two…”
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Pannexin 1 Constitutes the Large Conductance Cation Channel of Cardiac Myocytes by Kienitz, Marie-Cecile, Bender, Kirsten, Dermietzel, Rolf, Pott, Lutz, Zoidl, Georg

“…A large conductance (∼300 picosiemens) channel (LCC) of unknown molecular identity, activated by Ca2+ release from the sarcoplasmic reticulum, particularly…”
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Differential effects of genetically-encoded Gβγ scavengers on receptor-activated and basal Kir3.1/Kir3.4 channel current in rat atrial myocytes by Kienitz, Marie-Cécile, Mintert-Jancke, Elisa, Hertel, Fabian, Pott, Lutz

“…Opening of G-protein-activated inward-rectifying K+ (GIRK, Kir3) channels is regulated by interaction with βγ-subunits of Pertussis-toxin-sensitive G proteins…”
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Acute desensitization of GIRK current in rat atrial myocytes is related to K+ current flow by Kirsten Bender, Marie-Cécile Wellner-Kienitz, Leif I Bösche, Andreas Rinne, Christian Beckmann, Lutz Pott

“…We have investigated the acute desensitization of acetylcholine-activated GIRK current ( I K(ACh) ) in cultured adult rat atrial myocytes. Acute…”
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Gene silencing in adult rat cardiac myocytes in vitro by adenovirus-mediated RNA interference by Rinne, Andreas, Littwitz, Christoph, Kienitz, Marie-Cécile, Gmerek, Andreas, Bösche, Leif I, Pott, Lutz, Bender, Kirsten

“…RNA interference (RNAi) by short double stranded RNA (siRNA) represents an efficient and frequently used tool for gene silencing to study gene function…”
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Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors by Mavrommatis, Lampros, Jeong, Hyun-Woo, Kindler, Urs, Gomez-Giro, Gemma, Kienitz, Marie-Cecile, Stehling, Martin, Psathaki, Olympia E, Zeuschner, Dagmar, Bixel, M Gabriele, Han, Dong, Morosan-Puopolo, Gabriela, Gerovska, Daniela, Yang, Ji Hun, Kim, Jeong Beom, Arauzo-Bravo, Marcos J, Schwamborn, Jens C, Hahn, Stephan A, Adams, Ralf H, Schöler, Hans R, Vorgerd, Matthias, Brand-Saberi, Beate, Zaehres, Holm

“…In vitro culture systems that structurally model human myogenesis and promote PAX7 + myogenic progenitor maturation have not been established. Here we report…”
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Voltage dependence of ATP-dependent K+ current in rat cardiac myocytes is affected by IK1 and IK(ACh) by Wellner‐Kienitz, Marie‐Cécile, Bender, Kirsten, Rinne, Andreas, Pott, Lutz

“…In this study we have investigated the voltage dependence of ATP-dependent K + current ( I K(ATP) ) in atrial and ventricular myocytes from hearts of adult…”
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G Protein-Independent Inhibition of GIRK Current by Adenosine in Rat Atrial Myocytes Overexpressing A1 Receptors after Adenovirus-Mediated Gene Transfer by Bösche, Leif I., Wellner‐Kienitz, Marie‐Cécile, Bender, Kirsten, Pott, Lutz

“…G protein-activated inwardly rectifying K + (GIRK) channels, important regulators of membrane excitability in the heart and central nervous system, are…”
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Autocrine signaling via A1 adenosine receptors causes downregulation of M2 receptors in adult rat atrial myocytes in vitro by Littwitz, Christoph, Timpert, Mathias, Bender, Kirsten, Pott, Lutz, Kienitz, Marie-Cécile

“…G protein-activated K + channels composed of Kir3 (GIRK) subunits contribute to regulation of heart rate and excitability. Opening of these channels in…”
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