Search Results - "Kiem, H P"

Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers by Moffett, H. F., Coon, M. E., Radtke, S., Stephan, S. B., McKnight, L., Lambert, A., Stoddard, B. L., Kiem, H. P., Stephan, M. T.

“…Therapies based on immune cells have been applied for diseases ranging from cancer to diabetes. However, the viral and electroporation methods used to create…”
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Combinatorial anti-HIV gene therapy: using a multipronged approach to reach beyond HAART by Peterson, C W, Younan, P, Jerome, K R, Kiem, H-P

“…The ‘Berlin Patient’, who maintains suppressed levels of HIV viremia in the absence of antiretroviral therapy, continues to be a standard bearer in HIV…”
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Large animal models of hematopoietic stem cell gene therapy by Trobridge, G D, Kiem, H-P

“…Large animal models have been instrumental in advancing hematopoietic stem cell (HSC) gene therapy. Here we review the advantages of large animal models, their…”
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Dose-adapted post-transplant cyclophosphamide for HLA-haploidentical transplantation in Fanconi anemia by Thakar, M S, Bonfim, C, Walters, M C, Storb, R, Pasquini, R, Burroughs, L, Sandmaier, B M, Woolfrey, A, Kiem, H-P

“…We developed a haploidentical transplantation protocol with post-transplant cyclophosphamide (CY) for in vivo T-cell depletion (TCD) using a novel…”
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Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection by Olszko, M E, Adair, J E, Linde, I, Rae, D T, Trobridge, P, Hocum, J D, Rawlings, D J, Kiem, H-P, Trobridge, G D

“…Foamy virus (FV) vectors are promising for hematopoietic stem cell (HSC) gene therapy but preclinical data on the clonal composition of FV vector-transduced…”
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Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo by Kiem, H-P, Wu, R A, Sun, G, von Laer, D, Rossi, J J, Trobridge, G D

“…Highly active antiretroviral therapy has greatly reduced the morbidity and mortality from human immunodeficiency virus (HIV) infection, but AIDS continues to…”
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Marrow grafts from HLA-identical siblings for severe aplastic anemia: does limiting the number of transplanted marrow cells reduce the risk of chronic GvHD? by Gallo, S, Woolfrey, A E, Burroughs, L M, Storer, B E, Flowers, M E D, Hari, P, Pulsipher, M A, Heimfeld, S, Kiem, H-P, Sandmaier, B M, Storb, R

“…A total of 21 patients with severe aplastic anemia (SAA) underwent marrow transplantation from HLA-identical siblings following a standard conditioning regimen…”
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Combinatorial hematopoietic stem cell transplantation and vaccination reduces viral pathogenesis following SHIV89.6P-challenge by Younan, P M, Polacino, P, Kowalski, J P, Hu, S-L, Kiem, H-P

“…Development of curative approaches for HIV-1 infected patients requires novel approaches aimed at eliminating viral reservoirs and replacing potential target…”
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Rapid 1-hour transduction of whole bone marrow leads to long-term repopulation of murine recipients with lentivirus-modified hematopoietic stem cells by KURRE, P, ANANDAKUMAR, P, KIEM, H.-P

“…Efficient gene transfer to hematopoietic stem cells by Moloney murine leukemia virus-derived retroviral vectors benefits from ex vivo culture and cytokine…”
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Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector by Becker, P S, Taylor, J A, Trobridge, G D, Zhao, X, Beard, B C, Chien, S, Adair, J, Kohn, D B, Wagner, J E, Shimamura, A, Kiem, H-P

“…One of the major hurdles for the development of gene therapy for Fanconi anemia (FA) is the increased sensitivity of FA stem cells to free radical-induced DNA…”
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In vivo selection of autologous MGMT gene-modified cells following reduced-intensity conditioning with BCNU and temozolomide in the dog model by Gori, J L, Beard, B C, Ironside, C, Karponi, G, Kiem, H-P

“…Chemotherapy with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) and temozolomide (TMZ) is commonly used for the treatment of glioblastoma multiforme (GBM) and…”
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S207: EFFICACY AND SAFETY OF A THIRD GENERATION CD20 CART (MB‐106) FOR TREATMENT OF RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA (FL) by Shadman, M., Yeung, C., Redman, M., Lee, S. Y., Lee, D. H., Ra, S., Qian, D., Ujjani, C., Dezube, B., Poh, C., Warren, E. H., Chapuis, A., Green, D., Cowan, A., Cassaday, R., Kiem, H.‐P., Chow, V., Gauthier, J., Turtle, C., Lynch, R., Smith, S., Gopal, A., Maloney, D., Till, B.

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NOD SCID repopulating cells contribute only to short-term repopulation in the baboon by Mezquita, P, Beard, B C, Kiem, H-P

“…We have previously compared the repopulation ability of gene-modified baboon CD34 + cells in an autologous transplantation versus a xenotransplant model in…”
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Treatment of Fanconi anemia patients using fludarabine and low-dose TBI, followed by unrelated donor hematopoietic cell transplantation by Thakar, M S, Kurre, P, Storb, R, Kletzel, M, Frangoul, H, Pulsipher, M A, Leisenring, W, Flowers, M E D, Sandmaier, B M, Woolfrey, A, Kiem, H-P

“…A nonmyeloablative conditioning regimen consisting of fludarabine (FLU) and 2 Gy TBI has been used extensively and with substantial engraftment success without…”
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Lentivirus-mediated gene transfer into hematopoietic repopulating cells in baboons by HORN, P. A, MORRIS, J. C, BUKOVSKY, A. A, ANDREWS, R. G, NALDINI, L, KURRE, P, KIEM, H.-P

“…Efficient transduction of hematopoietic stem cells is a prerequisite for successful hematopoietic stem cell gene therapy. Oncoretroviral vectors are the most…”
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Lentiviral vector conferring resistance to mycophenolate mofetil and sensitivity to ganciclovir for in vivo T-cell selection by SANGIOLO, D, LESNIKOVA, M, NASH, R. A, JENSEN, M. C, NIKITINE, A, KIEM, H.-P, GEORGES, G. E

“…Several clinical studies of gene-modified T cells have shown limited in vivo function of the cells, immunogenicity of the transgene, and lack of a selective…”
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Cyclosporine inhibits the development of green fluorescent protein (GFP)-specific immune responses after transplantation of GFP-expressing hematopoietic repopulating cells in dogs by Beagles, K E, Peterson, L, Zhang, X, Morris, J, Kiem, H-P

“…Green fluorescent proteins (GFPs) have been widely used to monitor gene transfer and expression after lentiviral and oncoretroviral transduction of…”
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Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation by STORB, R, YU, C, WAGNER, J. L, DEEG, H. J, NASH, R. A, KIEM, H.-P, LEISENRING, W, SHULMAN, H

“…Postgrafting cyclosporine (CSP) given for 35 days resulted in establishment of stable marrow grafts from DLA-identical canine littermates after otherwise…”
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Recombinant factor VIII expression in hematopoietic cells following lentiviral transduction by TIEDE, A, EDER, M, VON DEPKA, M, BATTMER, K, LUTHER, S, KIEM, H-P, GANSER, A, SCHERR, M

“…Autologous transplantation of gene-modified hematopoietic stem cells may provide a therapeutic strategy for several monogeneic disorders. In previous studies,…”
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Low‐dose cyclophosphamide conditioning for haematopoietic cell transplantation from HLA‐matched related donors in patients with Fanconi anaemia by Zanis‐Neto, J., Flowers, M. E. D., Medeiros, C. R., Bitencourt, M. A., Bonfim, C. M., Setúbal, D. C., Funke, V., Sanders, J., Deeg, H. J., Kiem, H. P., Martin, P., Leisenring, W., Storb, R., Pasquini, R.

“…Summary Allogeneic haematopoietic cell transplantation (HCT) is effective therapy for Fanconi anaemia (FA). FA patients do not tolerate conditioning with 200…”
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