Search Results - "Kielland, Nicola"

Modern Synthetic Avenues for the Preparation of Functional Fluorophores by de Moliner, Fabio, Kielland, Nicola, Lavilla, Rodolfo, Vendrell, Marc

“…Biomedical research relies on the fast and accurate profiling of specific biomolecules and cells in a non‐invasive manner. Functional fluorophores are powerful…”
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Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue by Mendive-Tapia, Lorena, Zhao, Can, Akram, Ahsan R., Preciado, Sara, Albericio, Fernando, Lee, Martin, Serrels, Alan, Kielland, Nicola, Read, Nick D, Lavilla, Rodolfo, Vendrell, Marc

“…Fluorescent antimicrobial peptides are promising structures for in situ , real-time imaging of fungal infection. Here we report a fluorogenic probe to image…”
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New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues by Mendive-Tapia, Lorena, Preciado, Sara, García, Jesús, Ramón, Rosario, Kielland, Nicola, Albericio, Fernando, Lavilla, Rodolfo

“…Natural peptides show high degrees of specificity in their biological action. However, their therapeutical profile is severely limited by their conformational…”
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A Powerful Aluminum Catalyst for the Synthesis of Highly Functional Organic Carbonates by Whiteoak, Christopher J, Kielland, Nicola, Laserna, Victor, Escudero-Adán, Eduardo C, Martin, Eddy, Kleij, Arjan W

“…An aluminum complex based on an amino triphenolate ligand scaffold shows unprecedented high activity (initial TOFs up to 36 000 h–1), broad substrate scope,…”
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Multicomponent Reactions for de Novo Synthesis of BODIPY Probes: In Vivo Imaging of Phagocytic Macrophages by Vázquez-Romero, Ana, Kielland, Nicola, Arévalo, María J, Preciado, Sara, Mellanby, Richard J, Feng, Yi, Lavilla, Rodolfo, Vendrell, Marc

“…Multicomponent reactions are excellent tools to generate complex structures with broad chemical diversity and fluorescent properties. Herein we describe the…”
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Electrophilic, Activation-Free Fluorogenic Reagent for Labeling Bioactive Amines by Sintes, Miquel, De Moliner, Fabio, Caballero-Lima, David, Denning, David W, Read, Nick D, Kielland, Nicola, Vendrell, Marc, Lavilla, Rodolfo

“…Herein we report the preparation of BODIPY mesoionic acid fluorides through a short sequence involving an isocyanide multicomponent reaction as the key…”
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Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases by Ghashghaei, Ouldouz, Kielland, Nicola, Revés, Marc, Taylor, Martin C, Kelly, John M, Di Pietro, Ornella, Muñoz-Torrero, Diego, Pérez, Belén, Lavilla, Rodolfo

“…Imidazolium salts are privileged compounds in organic chemistry, and have valuable biological properties. Recent studies show that symmetric imidazolium salts…”
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Stereoselective Synthesis with Carbon Dioxide by Kielland, Nicola, Whiteoak, Christopher J., Kleij, Arjan W.

“…Homogeneous catalysis employing carbon dioxide (CO2) as a carbon‐based renewable feedstock has been and continues to be a flourishing area of research,…”
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Highly Active Aluminium Catalysts for the Formation of Organic Carbonates from CO2 and Oxiranes by Whiteoak, Christopher J., Kielland, Nicola, Laserna, Victor, Castro-Gómez, Fernando, Martin, Eddy, Escudero-Adán, Eduardo C., Bo, Carles, Kleij, Arjan W.

“…AlIII complexes of amino‐tris(phenolate) ligand scaffolds have been prepared to attain highly Lewis acidic catalysts. Combination of the aforementioned systems…”
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Modular Access to Tetrasubstituted Imidazolium Salts through Acid-Catalyzed Addition of Isocyanides to Propargylamines by Ghashghaei, Ouldouz, Revés, Marc, Kielland, Nicola, Lavilla, Rodolfo

“…Propargylamines, prepared through A3‐coupling of primary amines, aldehydes and terminal alkynes, react with isocyanides in an HCl‐catalyzed process to yield…”
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Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride by Kielland, Nicola, Vendrell, Marc, Lavilla, Rodolfo, Chang, Young-Tae

“…Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging…”
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Ugi Multicomponent Reaction Followed by an Intramolecular Nucleophilic Substitution:  Convergent Multicomponent Synthesis of 1-Sulfonyl 1,4-Diazepan-5-ones and of Their Benzo-Fused Derivatives by Banfi, Luca, Basso, Andrea, Guanti, Giuseppe, Kielland, Nicola, Repetto, Claudio, Riva, Renata

“…A short, two-step approach to the synthesis of diazepane or diazocane systems, based on a Ugi multicomponent reaction followed by a subsequent intramolecular…”
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Multiple Multicomponent Reactions: Unexplored Substrates, Selective Processes, and Versatile Chemotypes in Biomedicine by Ghashghaei, Ouldouz, Caputo, Samantha, Sintes, Miquel, Revés, Marc, Kielland, Nicola, Estarellas, Carolina, Luque, F. Javier, Aviñó, Anna, Eritja, Ramón, Serna‐Gallego, Ana, Marrugal‐Lorenzo, José Antonio, Pachón, Jerónimo, Sánchez‐Céspedes, Javier, Treadwell, Ryan, de Moliner, Fabio, Vendrell, Marc, Lavilla, Rodolfo

“…Multiple multicomponent reactions rapidly assemble complex structures. Despite being very productive, the lack of selectivity and the reduced number of viable…”
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Insertion of Isocyanides into N−Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds by Kishore, Kranti G., Ghashghaei, Ouldouz, Estarellas, Carolina, Mestre, M. Mar, Monturiol, Cristina, Kielland, Nicola, Kelly, John M., Francisco, Amanda Fortes, Jayawardhana, Shiromani, Muñoz-Torrero, Diego, Pérez, Belén, Luque, F. Javier, Gámez-Montaño, Rocío, Lavilla, Rodolfo

“…Trimethylsilyl chloride is an efficient activating agent for azines in isocyanide‐based reactions, which then proceed through a key insertion of the isocyanide…”
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Tetrasubstituted imidazolium salts as potent antiparasitic agents against African and American trypanosomiases by Ghashghaei, Ouldouz, Kielland, Nicola, Revés, Marc, Taylor, Martin C, Kelly, John M, Di Pietro, Ornella, Muñoz-Torrero López-Ibarra, Diego, Pérez, Belén, Lavilla Grífols, Rodolfo

“…Imidazolium salts are privileged compounds in organic chemistry, and have valuable biological properties. Recent studies show that symmetric imidazolium salts…”
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Two-electron connection between tryptophan and phenylalanine/tyrosine residues: linked, constrained and stapled peptides through C-H activation processes by Mendive Tapia, Lorena, Preciado Gallego, Sara, García, Jesús, Ramón, Rosario, Kielland, Nicola, Albericio Palomera, Fernando, Lavilla Grífols, Rodolfo

“…Natural peptides show high degrees of specificity in their biological action. However, their therapeutical profile is severely limited by their conformational…”
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A multicomponent reaction platform towards multimodal near-infrared BODIPY dyes for STED and fluorescence lifetime imaging by Fernandez, Antonio, Kielland, Nicola, Makda, Ashraff, Carragher, Neil O, González-García, M. Carmen, Espinar-Barranco, Laura, González-Vera, Juan A, Orte, Angel, Lavilla, Rodolfo, Vendrell, Marc

“…We report a platform combining multicomponent reaction synthesis and automated cell-based screening to develop biocompatible NIR-BODIPY fluorophores. From a…”
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Scope and Post-Transformations for the Borane-Isocyanide Multicomponent Reactions: Concise Access to Structurally Diverse Heterocyclic Compounds by Kielland, Nicola, Vicente-García, Esther, Revés, Marc, Isambert, Nicolas, Arévalo, María José, Lavilla, Rodolfo

“…A recently described family of multicomponent reactions (MCRs) involving isocyanides, aldehydes, dipolarophiles and alkylboranes that yield highly substituted…”
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Moderne Strategien zur Synthese funktioneller Fluorophore by de Moliner, Fabio, Kielland, Nicola, Lavilla, Rodolfo, Vendrell, Marc

“…Die biomedizinische Forschung ist auf die schnelle, akkurate und nicht‐invasive Charakterisierung spezifischer Biomoleküle und Zellen angewiesen. Funktionelle…”
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Highly Active Aluminium Catalysts for the Formation of Organic Carbonates from CO 2 and Oxiranes by Whiteoak, Christopher J., Kielland, Nicola, Laserna, Victor, Castro‐Gómez, Fernando, Martin, Eddy, Escudero‐Adán, Eduardo C., Bo, Carles, Kleij, Arjan W.

“…Abstract Al III complexes of amino‐tris(phenolate) ligand scaffolds have been prepared to attain highly Lewis acidic catalysts. Combination of the…”
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