Search Results - "Kielkopf, C L"

U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing by Okeyo-Owuor, T, White, B S, Chatrikhi, R, Mohan, D R, Kim, S, Griffith, M, Ding, L, Ketkar-Kulkarni, S, Hundal, J, Laird, K M, Kielkopf, C L, Ley, T J, Walter, M J, Graubert, T A

“…We previously identified missense mutations in the U2AF1 splicing factor affecting codons S34 (S34F and S34Y) or Q157 (Q157R and Q157P) in 11% of the patients…”
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Structure of a photoactive rhodium complex intercalated into DNA by Barton, Jacqueline K, Rees, Douglas C, Kielkopf, Clara L, Erkkila, Kathryn E, Hudson, Brian P

“…Intercalating complexes of rhodium(III) are strong photo-oxidants that promote DNA strand cleavage or electron transfer through the double helix. The 1.2 A…”
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Structural Basis for NADH/NAD+ Redox Sensing by a Rex Family Repressor by McLaughlin, Krystle J., Strain-Damerell, Claire M., Xie, Kefang, Brekasis, Dimitris, Soares, Alexei S., Paget, Mark S.B., Kielkopf, Clara L.

“…Nicotinamide adenine dinucleotides have emerged as key signals of the cellular redox state. Yet the structural basis for allosteric gene regulation by the…”
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A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA by KIELKOPF, C. L, WHITE, S, SZEWCZYK, J. W, TURNER, J. M, BAIRD, E. E, DERVAN, P. B, REES, D. C

“…Polyamide dimers containing three types of aromatic rings-pyrrole, imidazole, and hydroxypyrrole-afford a small-molecule recognition code that discriminates…”
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Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove by Kielkopf, C L, Bremer, R E, White, S, Szewczyk, J W, Turner, J M, Baird, E E, Dervan, P B, Rees, D C

“…Synthetic polyamides composed of three types of aromatic amino acids, N-methylimidazole (Im), N-methylpyrrole (Py) and N-methyl-3-hydroxypyrrole (Hp) bind…”
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U2AF homology motifs: protein recognition in the RRM world by Kielkopf, Clara L, Lücke, Stephan, Green, Michael R

“…Recent structures of the heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) have revealed two unexpected examples of RNA recognition motif…”
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Structural basis for GC recognition in the DNA minor groove by Kielkopf, Clara L, Baird, Eldon E, Dervan, Peter B, Rees, Douglas C

“…Small molecules that target specific DNA sequences offer a potentially general approach for the regulation of gene expression. Pyrrole-imidazole polyamides…”
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Structural basis for G•C recognition in the DNA minor groove by Kielkopf, Clara L., Baird, Eldon E., Dervan, Peter B., Rees, Douglas C.

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Different Requirements of the Kinase and UHM Domains of KIS for Its Nuclear Localization and Binding to Splicing Factors by Manceau, Valérie, Kielkopf, Clara L., Sobel, André, Maucuer, Alexandre

“…The protein kinase KIS is made by the juxtaposition of a unique kinase domain and a C-terminal domain with a U2AF homology motif (UHM), a sequence motif for…”
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A Structural Basis for Recognition of A·T and T·A Base Pairs in the Minor Groove of B-DNA by Kielkopf, Clara L., White, Sarah, Szewczyk, Jason W., Turner, James M., Baird, Eldon E., Dervan, Peter B., Rees, Douglas C.

“…Polyamide dimers containing three types of aromatic rings-pyrrole, imidazole, and hydroxypyrrole-afford a small-molecule recognition code that discriminates…”
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X-Ray Structure of a Rex-Family Repressor/NADH Complex Insights into the Mechanism of Redox Sensing by Sickmier, E. Allen, Brekasis, Dimitris, Paranawithana, Shanthi, Bonanno, Jeffrey B., Paget, Mark S.B., Burley, Stephen K., Kielkopf, Clara L.

“…The redox-sensing repressor Rex regulates transcription of respiratory genes in response to the intra cellular NADH/NAD + redox poise. As a step toward…”
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Conformational flexibility of B-DNA at 0.74 A resolution: d(CCAGTACTGG)(2) by Kielkopf, C L, Ding, S, Kuhn, P, Rees, D C

“…The affinity and specificity of a ligand for its DNA site is a function of the conformational changes between the isolated and complexed states. Although the…”
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A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer by Kielkopf, C L, Rodionova, N A, Green, M R, Burley, S K

“…U2 auxiliary factor (U2AF) is an essential splicing factor that recognizes the 3' splice site and recruits the U2 snRNP to the branch point. The X-ray…”
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Alternative Conformations at the RNA-binding Surface of the N-terminal U2AF super(6) super(5) RNA Recognition Motif by Thickman, K R, Sickmier, E A, Kielkopf, CL

“…The essential pre-mRNA splicing factor, U2 auxiliary factor 65KD (U2AF super(6) super(5)) recognizes the polypyrimidine tract (Py-tract) consensus sequence of…”
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Structure of a DNA Repair Substrate Containing an Alkyl Interstrand Cross-Link at 1.65 Å Resolution by Swenson, Matthew C, Paranawithana, Shanthi R, Miller, Paul S, Kielkopf, Clara L

“…Chemotherapeutic alkylating agents, such as bifunctional nitrogen mustards and cisplatins, generate interstrand DNA cross-links that inhibit cell proliferation…”
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X-ray Structures of Threonine Aldolase Complexes:  Structural Basis of Substrate Recognition by Kielkopf, Clara L, Burley, Stephen K

“…l-Threonine acetaldehyde-lyase (threonine aldolase, TA) is a pyridoxal-5‘-phosphate-dependent (PLP) enzyme that catalyzes conversion of l-threonine or…”
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Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution by Kumar, Amit O, Swenson, Matthew C, Benning, Matthew M, Kielkopf, Clara L

“…T-cell-restricted intracellular antigen-1 (TIA-1) regulates alternative pre-mRNA splicing in the nucleus, and mRNA translation in the cytoplasm, by recognizing…”
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Multiple U2AF super(6) super(5) Binding Sites within SF3b155: Thermodynamic and Spectroscopic Characterization of Protein-Protein Interactions among pre-mRNA Splicing Factors by Thickman, K R, Swenson, M C, Kabogo, J M, Gryczynski, Z, Kielkopf, CL

“…Essential, protein-protein complexes between the large subunit of the U2 small nuclear RNA auxiliary factor (U2AF super(6) super(5)) with the splicing factor 1…”
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A Novel Peptide Recognition Mode Revealed by the X-Ray Structure of a Core U2AF super(35)/U2AF super(65) Heterodimer by Kielkopf, CL, Rodionova, NA, Green, M R, Burley, S K

“…U2 auxiliary factor (U2AF) is an essential splicing factor that recognizes the 3' splice site and recruits the U2 snRNP to the branch point. The X-ray…”
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Conformational Flexibility of B -DNA at 0.74 Aa Resolution: d(CCAGTACTGG) sub(2) by Kielkopf, CL, Ding, S, Kuhn, P, Rees, D C

“…The affinity and specificity of a ligand for its DNA site is a function of the conformational changes between the isolated and complexed states. Although the…”
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