Search Results - "Kielczewski, Jennifer L."

Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site by Horai, Reiko, Zárate-Bladés, Carlos R., Dillenburg-Pilla, Patricia, Chen, Jun, Kielczewski, Jennifer L., Silver, Phyllis B., Jittayasothorn, Yingyos, Chan, Chi-Chao, Yamane, Hidehiro, Honda, Kenya, Caspi, Rachel R.

“…Activated retina-specific T cells that have acquired the ability to break through the blood-retinal barrier are thought to be causally involved in autoimmune…”
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Pseudovirus rVSVΔG-ZEBOV-GP Infects Neurons in Retina and CNS, Causing Apoptosis and Neurodegeneration in Neonatal Mice by McWilliams, Ian L., Kielczewski, Jennifer L., Ireland, Derek D.C., Sykes, Jacob S., Lewkowicz, Aaron P., Konduru, Krishnamurthy, Xu, Biying C., Chan, Chi-Chao, Caspi, Rachel R., Manangeeswaran, Mohanraj, Verthelyi, Daniela

“…Zaire Ebola virus (ZEBOV) survivors experience visual and CNS sequelae that suggests the ZEBOV glycoprotein can mediate neurotropism. Replication-competent…”
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EPCs and pathological angiogenesis: When good cells go bad by Calzi, Sergio Li, Neu, Matthew B., Shaw, Lynn C., Kielczewski, Jennifer L., Moldovan, Nicanor I., Grant, Maria B.

“…Bone-marrow-derived endothelial progenitor cells (EPCs) contribute to angiogenesis-mediated pathological neovascularization, and recent studies have begun to…”
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The Effect of Experimental Glaucoma and Optic Nerve Transection on Amacrine Cells in the Rat Retina by Kielczewski, Jennifer L, Pease, Mary Ellen, Quigley, Harry A

“…To detect alterations in amacrine cells associated with retinal ganglion cell (RGC) depletion caused by experimental optic nerve transection and glaucoma…”
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Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3 by Jarajapu, Yagna P R, Cai, Jun, Yan, Yuanqing, Li Calzi, Sergio, Kielczewski, Jennifer L, Hu, Ping, Shaw, Lynn C, Firth, Sue M, Chan-Ling, Tailoi, Boulton, Michael E, Baxter, Robert C, Grant, Maria B

“…Previously, we showed that insulin growth factor (IGF)-1 binding protein-3 (IGFBP-3), independent of IGF-1, reduces pathological angiogenesis in a mouse model…”
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Tertiary Lymphoid Tissue Forms in Retinas of Mice with Spontaneous Autoimmune Uveitis and Has Consequences on Visual Function by Kielczewski, Jennifer L, Horai, Reiko, Jittayasothorn, Yingyos, Chan, Chi-Chao, Caspi, Rachel R

“…During chronic inflammation, tertiary lymphoid tissue (TLT) can form within an inflamed organ, including the CNS. However, little is known about TLT formation…”
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Interleukin 22 ameliorates neuropathology and protects from central nervous system autoimmunity by Mattapallil, Mary J., Kielczewski, Jennifer L., Zárate-Bladés, Carlos R., St Leger, Anthony J., Raychaudhuri, Kumarkrishna, Silver, Phyllis B., Jittayasothorn, Yingyos, Chan, Chi-Chao, Caspi, Rachel R.

“…IL-22 has opposing effects in different tissues, from pro-inflammatory (skin, joints) to protective (liver, intestine) but little is known about its effects on…”
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ZIKA virus infection causes persistent chorioretinal lesions by Manangeeswaran, Mohanraj, Kielczewski, Jennifer L., Sen, H. Nida, Xu, Biying C., Ireland, Derek. D.C., McWilliams, Ian L., Chan, Chi-Chao, Caspi, Rachel R., Verthelyi, Daniela

“…Zika-infected patients can have eye involvement ranging from mild conjunctivitis to severe chorioretinal lesions, however the possible long-term sequelae of…”
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Ebola virus-induced eye sequelae: a murine model for evaluating glycoprotein-targeting therapeutics by Lee, Ha-Na, Xu, Biying, Lewkowicz, Aaron P., Engel, Kaliroi, Kelley-Baker, Logan, McWilliams, Ian L., Ireland, Derek D.C., Kielczewski, Jennifer L., Li, Jinbo, Fariss, Robert N., Campos, Mercedes M., Baum, Alina, Kyratsous, Christos, Pascal, Kristen, Chan, Chi-Chao, Caspi, Rachel R., Manangeeswaran, Mohanraj, Verthelyi, Daniela

“…Ebola virus disease (EVD) survivors experience ocular sequelae including retinal lesions, cataracts, and vision loss. While monoclonal antibodies targeting the…”
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Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair by Enhancing Nitric Oxide Generation by Kielczewski, Jennifer L, Jarajapu, Yagna P.R, McFarland, Evan L, Cai, Jun, Afzal, Aqeela, Li Calzi, Sergio, Chang, Kyung Hee, Lydic, Todd, Shaw, Lynn C, Busik, Julia, Hughes, Jeffrey, Cardounel, Arturo J, Wilson, Kenneth, Lyons, Timothy J, Boulton, Michael E, Mames, Robert N, Chan-Ling, Tailoi, Grant, Maria B

“…RATIONALE:Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior,…”
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Novel Protective Properties of IGFBP-3 Result in Enhanced Pericyte Ensheathment, Reduced Microglial Activation, Increased Microglial Apoptosis, and Neuronal Protection after Ischemic Retinal Injury by Kielczewski, Jennifer L, Hu, Ping, Shaw, Lynn C, Li Calzi, Sergio, Mames, Robert N, Gardiner, Tom A, McFarland, Evan, Chan-Ling, Tailoi, Grant, Maria B

“…This study was conducted to determine the perivascular cell responses to increased endothelial cell expression of insulin-like growth factor binding protein-3…”
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Characteristics of Progenitor Cells Derived from Adult Ciliary Body in Mouse, Rat, and Human Eyes by Xu, Hangxiu, Iglesia, Drina D. Sta, Kielczewski, Jennifer L, Valenta, Danielle F, Pease, Mary E, Zack, Donald J, Quigley, Harry A

“…To isolate and characterize progenitor cells derived from adult mammalian ciliary body. The authors isolated progenitor cells from the ciliary body of adult…”
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An ocular view of the IGF–IGFBP system by Nguyen, Dung V, Li Calzi, Sergio, Shaw, Lynn C, Kielczewski, Jennifer L, Korah, Hannah E, Grant, Maria B

“…Abstract IGFs and their binding proteins have been shown to exhibit both protective and deleterious effects in ocular disease. Recent studies have…”
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Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase) by Kielczewski, Jennifer L, Li Calzi, Sergio, Shaw, Lynn C, Cai, Jun, Qi, Xiaoping, Ruan, Qing, Wu, Lin, Liu, Li, Hu, Ping, Chan-Ling, Tailoi, Mames, Robert N, Firth, Sue, Baxter, Robert C, Turowski, Patric, Busik, Julia V, Boulton, Michael E, Grant, Maria B

“…To examine the effect of free insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), independent of the effect of insulin-like growth factors, in…”
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Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype by Mattapallil, Mary J, Silver, Phyllis B, Cortes, Lizette M, St Leger, Anthony J, Jittayasothorn, Yingyos, Kielczewski, Jennifer L, Moon, James J, Chan, Chi-Chao, Caspi, Rachel R

“…Experimental autoimmune uveitis (EAU) induced in mice using the retinal antigen interphotoreceptor retinoid binding protein (IRBP) is an animal model for…”
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Regulation of Adult Hematopoietic Stem Cells Fate for Enhanced Tissue-specific Repair by Sengupta, Nilanjana, Caballero, Sergio, Sullivan, Sean M, Chang, Lung-Ji, Afzal, Aqeela, Li Calzi, Sergio, Kielczewski, Jennifer L, Prabarakan, Sabrina, Ellis, E Ann, Moldovan, Leni, Moldovan, Nicanor I, Boulton, Michael E, Grant, Maria B

“…The ability to control the differentiation of adult hematopoietic stem cells (HSCs) would promote development of new cell-based therapies to treat multiple…”
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Ebola virus-induced eye sequelae: a murine model for evaluating glycoprotein-targeting therapeuticsResearch in context by Ha-Na Lee, Biying Xu, Aaron P. Lewkowicz, Kaliroi Engel, Logan Kelley-Baker, Ian L. McWilliams, Derek D.C. Ireland, Jennifer L. Kielczewski, Jinbo Li, Robert N. Fariss, Mercedes M. Campos, Alina Baum, Christos Kyratsous, Kristen Pascal, Chi-Chao Chan, Rachel R. Caspi, Mohanraj Manangeeswaran, Daniela Verthelyi

“…Background: Ebola virus disease (EVD) survivors experience ocular sequelae including retinal lesions, cataracts, and vision loss. While monoclonal antibodies…”
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Abstract 4883: Insulin-like Growth Factor Binding Protein-3 (IGFBP3) Modulates Vascular Tone via Scavenging Receptor-B1 (SRB1)-Dependent Nitric Oxide Release by Jarajapu, Yagna P, Kielczewski, Jennifer L, Baxter, Robert C, Grant, Maria B

“…Abstract only Purpose: We recently reported the vascular protective effect of IGFBP3 in experimental models of ischemic vascular injury involving increased…”
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Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2 b Haplotype by Mattapallil, Mary J., Silver, Phyllis B., Cortes, Lizette M., St. Leger, Anthony J., Jittayasothorn, Yingyos, Kielczewski, Jennifer L., Moon, James J., Chan, Chi-Chao, Caspi, Rachel R.

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Abstract 1746: Insulin Like Growth Factor Binding Protein-3 (IGFBP-3) Mediates Vascular Repair By HDL Receptor Activation And Sphingosine Kinase (SK-1)/Sphingosine 1-Phosphate (S1P) Dependent Nitric Oxide (NO) Generation by Calzi, Sergio Li, Kielczewski, Jennifer L, McFarland, Evan, Chang, Kyung Hee, Afzal, Aqeela, Shaw, Lynn C, Jarajapu, Yagna, Chan-Ling, Tailoi, Grant, Maria B

“…Abstract only Purpose: We demonstrated that IGFBP-3 stimulates hematopoietic stem cells (HSC) to differentiate into endothelial cells, form capillaries, and…”
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