Search Results - "Kiehr, B"

Combination of 'omics' data to investigate the mechanism(s) of hydrazine-induced hepatotoxicity in Rats and to identify potential biomarkers by Klenø, T. G., Kiehr, B., Baunsgaard, D., Sidelmann, U. G.

“…To gain novel insight into the molecular mechanisms underlying hydrazine-induced hepatotoxicity, mRNAs, proteins and endogenous metabolites were identified…”
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Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo by Kurtzhals, P, Havelund, S, Jonassen, I, Kiehr, B, Larsen, U D, Ribel, U, Markussen, J

“…Albumin is a multifunctional transport protein that binds a wide variety of endogenous substances and drugs. Insulins with affinity for albumin were engineered…”
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Characterization of high molecular weight plasma protein complexes induced by clotting factor rFXIII‐treatment in the cynomolgus monkey by SCHAAL‐JENSEN, R., KIEHR, B., BOESEN, H. T., KRABBE, J. S., SOMMER, C., JACOBSEN, H., OLEKSIEWICZ, M. B.

“…Background: In cynomolgus monkeys, suprapharmacological doses of clotting recombinant factor XIII (rFXIII) cause a generalized coagulopathy, associated with…”
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Preclinical toxicity biomarkers for combination treatment with clotting factors rFXIII and rFVIIa by Oleksiewicz, M. B., Schaal-Jensen, R., Kiehr, B., Steenbuch Krabbe, J., Sommer, C.

“…Abstract Combination treatment with the clotting factors recombinant activated factor VII (rFVIIa), serine protease, and recombinant factor XIII (rFXIII),…”
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Levormeloxifene: safety, pharmacodynamics and pharmacokinetics in healthy postmenopausal women following single and multiple doses of a new selective oestrogen receptor modulator by Skrumsager, Birte K., Kiehr, Benedicte, Pedersen, Poul Christian, Gerrits, Mireille, Watson, Norma, Bjarnason, Ketil

“…Aims  The safety, pharmacodynamics and pharmacokinetics of levormeloxifene, a selective oestrogen receptor modulator (SERM), were investigated in…”
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Levormeloxifene: Safety & Pharmacokinetics in Young Versus Elderly Postmenopausal Women by Skrumsager, B.K., Müller, M., Kiehr, B.

“…Clinical Pharmacology & Therapeutics (1999) 65, 192–192; doi:…”
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Pharmacokinetics and allometric scaling of levormeloxifene, a selective oestrogen receptor modulator by Østerberg, O., Kiehr, B., Erichsen, L., Poulsen, H.E., Ingwersen, S.H.

“…The pharmacokinetics of a new selective oestrogen receptor modulator levormeloxifene was investigated in mice, rats, cynomolgus monkeys and humans by…”
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Albumin binding and time action of acylated insulins in various species by Kurtzhals, P, Havelund, S, Jonassen, I, Kiehr, B, Ribel, U, Markussen, J

“…Insulins acylated with fatty acids at the epsilon-amino group of LysB29 constitute a new class of insulin analogs, which are prolonged-acting due to albumin…”
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Metabolism, Disposition, Excretion, and Pharmacokinetics of Levormeloxifene, A Selective Estrogen Receptor Modulator, in the Rat by MOUNTFIELD, R. J, KIEHR, B, JOHN, B. A

“…The tissue distribution, pharmacokinetics, metabolism, and excretion of the selective estrogen receptor modulator levormeloxifene have been investigated after…”
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Assay for levormeloxifene, a selective estrogen receptor modulator, in human and monkey plasma employing high-performance liquid chromatography and solid-phase extraction by Kiehr, Benedicte, Christensen, Michael S

“…Assays for levormeloxifene, a new selective estrogen receptor modulator, and its 7-desmethyl metabolite in human and cynomolgus monkey plasma are described…”
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Pharmacokinetics of levormeloxifene in young versus elderly postmenopausal women by Kiehr, Benedicte, Skrumsager, Birte K., Müller, Margarete, Pedersen, Poul C.

“…Background: Physiologic changes of aging may affect processes of drug absorption and distribution, in some cases necessitating age-dependent dose adjustment…”
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The cobalt(III)-insulin hexamer is a prolonged-acting insulin prodrug by Kurtzhals, P, Kiehr, B, Sørensen, A R

“…The insulin hexamer has two high-affinity metal ion binding sites, each involving three HisB10 residues, one from each dimer. Insulin hexamers containing Co2+…”
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Non-linear mixed effects modeling of sparse concentration data from rats: application to a glycogen phosphorylase inhibitor by Ingwersen, Steen H, Kiehr, Benedicte, Iversen, Lars, Andersen, Michael P, Petersen, Yvonne, Rytved, Klaus A

“…We investigated the use of non-linear mixed effects modeling in two preclinical studies of the glycogen phosphorylase inhibitor…”
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