Search Results - "Kiehntopf, Michael"

Antioxidants Prevent Health-Promoting Effects of Physical Exercise in Humans by Ristow, Michael, Zarse, Kim, Oberbach, Andreas, Klöting, Nora, Birringer, Marc, Kiehntopf, Michael, Stumvoll, Michael, Kahn, C. Ronald, Blüher, Matthias

“…Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance. However, exercise also increases mitochondrial formation of…”
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Multiplex quantification of C-terminal alpha-1-antitrypsin peptides provides a novel approach for characterizing systemic inflammation by Bigalke, Arite, Sponholz, Christoph, Schnabel, Claudia, Bauer, Michael, Kiehntopf, Michael

“…C-terminal peptides (CAAPs) of the highly abundant serine protease alpha-1-antitrypsin (A1AT) have been identified at various lengths in several human…”
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Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients by Schmerler, Diana, Neugebauer, Sophie, Ludewig, Katrin, Bremer-Streck, Sibylle, Brunkhorst, Frank Martin, Kiehntopf, Michael

“…The occurrence of systemic inflammatory response syndrome (SIRS) remains a major problem in intensive care units with high morbidity and mortality. The…”
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Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis by Brunkhorst, Frank M, Engel, Christoph, Bloos, Frank, Meier-Hellmann, Andreas, Ragaller, Max, Weiler, Norbert, Moerer, Onnen, Gruendling, Matthias, Oppert, Michael, Grond, Stefan, Olthoff, Derk, Jaschinski, Ulrich, John, Stefan, Rossaint, Rolf, Welte, Tobias, Schaefer, Martin, Kern, Peter, Kuhnt, Evelyn, Kiehntopf, Michael, Hartog, Christiane, Natanson, Charles, Loeffler, Markus, Reinhart, Konrad

“…Optimal glucose control and fluid resuscitation in patients with septic shock remain a challenge. In this study involving more than 500 patients, the potential…”
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Simultaneous Quantification of Nine Antimicrobials by LC-MS/MS for Therapeutic Drug Monitoring in Critically Ill Patients by Neugebauer, Sophie, Wichmann, Christina, Bremer-Streck, Sibylle, Hagel, Stefan, Kiehntopf, Michael

“…Adequate antibiotic treatment is a prerequisite for the successful treatment of systemic infections. Based on accumulating scientific evidence, a fixed dosage…”
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Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance by Caratti, Giorgio, Stifel, Ulrich, Caratti, Bozhena, Jamil, Ali J. M., Chung, Kyoung-Jin, Kiehntopf, Michael, Gräler, Markus H., Blüher, Matthias, Rauch, Alexander, Tuckermann, Jan P.

“…Insulin resistance (IR) during obesity is linked to adipose tissue macrophage (ATM)-driven inflammation of adipose tissue. Whether anti-inflammatory…”
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Nutrient Intake and Nutrition Status in Vegetarians and Vegans in Comparison to Omnivores - the Nutritional Evaluation (NuEva) Study by Dawczynski, Christine, Weidauer, Thomas, Richert, Cora, Schlattmann, Peter, Dawczynski, Kristin, Kiehntopf, Michael

“…In recent years, vegetarian and vegan diets became increasingly important as they are associated with beneficial health outcomes. Therefore, the NuEva study…”
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Validation of Nutritional Approaches to Modulate Cardiovascular and Diabetic Risk Factors in Patients with Hypertriglyceridemia or Prediabetes-The MoKaRi II Randomized Controlled Study by Braun, Theresa S, Drobner, Timo, Kipp, Kristin, Kiehntopf, Michael, Schlattmann, Peter, Lorkowski, Stefan, Dawczynski, Christine

“…Hypertriglyceridemia and diabetes mellitus type 2 are among the most important metabolic diseases globally. Diet plays a vital role in the development and…”
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Immunoadsorption to treat patients with severe post‐COVID syndrome by Giszas, Benjamin, Reuken, Philipp A., Katzer, Katrin, Kiehntopf, Michael, Schmerler, Diana, Rummler, Silke, Stallmach, Andreas, Klink, Anne

“…Introduction Following SARS‐CoV‐2‐infection up to 21% of patients will develop post‐COVID‐syndrome. Autoantibodies (AAbs) targeting neuronal‐ß‐adrenergic and…”
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Consequences of a high phosphorus intake on mineral metabolism and bone remodeling in dependence of calcium intake in healthy subjects - a randomized placebo-controlled human intervention study by Trautvetter, Ulrike, Jahreis, Gerhard, Kiehntopf, Michael, Glei, Michael

“…Epidemiological studies reported an association between plasma phosphate concentrations and a higher risk for death and cardiovascular events in subjects free…”
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Evaluation of Influencing Factors on Metabolism of Land-Based n-3 Poly Unsaturated Fatty Acids—The KoALA Study by Drobner, Timo, Braun, Theresa S., Kiehntopf, Michael, Schlattmann, Peter, Lorkowski, Stefan, Dawczynski, Christine

“…This study aimed to investigate the impact of influencing factors (sex, eicosapentaenoic acid (EPA) status at baseline, linoleic acid (LA) intake, milk fat…”
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Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk by Leonhardt, Julia, Dorresteijn, Mirrin J, Neugebauer, Sophie, Mihaylov, Diana, Kunze, Julia, Rubio, Ignacio, Hohberger, Frank-Stephan, Leonhardt, Silke, Kiehntopf, Michael, Stahl, Klaus, Bode, Christian, David, Sascha, Wagener, Frank A D T G, Pickkers, Peter, Bauer, Michael

“…Sepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better understanding of the underlying…”
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The Role of the N-Terminal Domain of Thrombomodulin and the Potential of Recombinant Human Thrombomodulin as a Therapeutic Intervention for Shiga Toxin-Induced Hemolytic-Uremic Syndrome by Kröller, Sarah, Schober, Jana, Krieg, Nadine, Dennhardt, Sophie, Pirschel, Wiebke, Kiehntopf, Michael, Conway, Edward M, Coldewey, Sina M

“…Hemolytic-uremic syndrome (HUS) is a rare complication of an infection with Shiga toxin (Stx)-producing (STEC-HUS), characterized by severe acute kidney…”
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Imbalance of von Willebrand factor and its cleaving protease ADAMTS13 during systemic inflammation superimposed on advanced cirrhosis by Reuken, Philipp A., Kussmann, Anna, Kiehntopf, Michael, Budde, Ulrich, Stallmach, Andreas, Claus, Ralf A., Bruns, Tony

“…Background & Aims Systemic inflammation in advanced cirrhosis represents a spectrum ranging from subclinical pathological bacterial translocation and immune…”
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Impact of Regular Intake of Microalgae on Nutrient Supply and Cardiovascular Risk Factors: Results from the NovAL Intervention Study by Sandgruber, Fabian, Höger, Anna-Lena, Kunze, Julia, Schenz, Benjamin, Griehl, Carola, Kiehntopf, Michael, Kipp, Kristin, Kühn, Julia, Stangl, Gabriele I, Lorkowski, Stefan, Dawczynski, Christine

“…A 14-day randomized controlled study with a parallel design was conducted with 80 healthy participants. Intervention groups I (IG1) and II (IG2) received a…”
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Candida albicans β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages by Leonhardt, Julia, Große, Silke, Marx, Christian, Siwczak, Fatina, Stengel, Sven, Bruns, Tony, Bauer, Reinhard, Kiehntopf, Michael, Williams, David L, Wang, Zhao-Qi, Mosig, Alexander S, Weis, Sebastian, Bauer, Michael, Heller, Regine

“…β-Glucan derived from cell walls of is a potent immune modulator. It has been shown to induce trained immunity in monocytes via epigenetic and metabolic…”
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Integrated Analysis of the Cerebrospinal Fluid Peptidome and Proteome by Zougman, Alexandre, Pilch, Bartosz, Podtelejnikov, Alexandre, Kiehntopf, Michael, Schnabel, Claudia, Kumar, Chanchal, Mann, Matthias

“…Cerebrospinal fluid (CSF) is the only body fluid in direct contact with the brain and thus is a potential source of biomarkers. Furthermore, CSF serves as a…”
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Lupin protein positively affects plasma LDL cholesterol and LDL:HDL cholesterol ratio in hypercholesterolemic adults after four weeks of supplementation: a randomized, controlled crossover study by Bähr, Melanie, Fechner, Anita, Krämer, Julia, Kiehntopf, Michael, Jahreis, Gerhard

“…A couple of studies indicate a favorable impact of lupin protein on cardiovascular risk factors in humans. These studies, however, used relatively high doses…”
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Persistent humoral and CD4+ TH cell immunity after mild SARS-COV-2 infection—The CoNAN long-term study by Schnizer, Clara, Andreas, Nico, Vivas, Wolfgang, Kamradt, Thomas, Baier, Michael, Kiehntopf, Michael, Glöckner, Stefan, Scherag, André, Löffler, Bettina, Kolanos, Steffi, Guerra, Joel, Pletz, Mathias W., Weis, Sebastian

“…Understanding persistent cellular and humoral immune responses to SARS-CoV-2 will be of major importance to terminate the ongoing pandemic. Here, we assessed…”
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Role of catecholamines in maternal-fetal stress transfer in sheep by Rakers, Florian, MD, Bischoff, Sabine, DVM, Schiffner, Rene, MD, Haase, Michelle, MD, Rupprecht, Sven, MD, Kiehntopf, Michael, MD, PhD, Kühn-Velten, W. Nikolaus, MD, PhD, Schubert, Harald, PhD, Witte, Otto W., MD, PhD, Nijland, Mark J., PhD, Nathanielsz, Peter W., MD, PhD, Schwab, Matthias, MD, PhD

“…Objective We sought to evaluate whether in addition to cortisol, catecholamines also transfer psychosocial stress indirectly to the fetus by decreasing uterine…”
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