Search Results - "Kieffer, Tara L."

Telaprevir and pegylated interferon–alpha‐2a inhibit wild‐type and resistant genotype 1 hepatitis C virus replication in patients by Kieffer, Tara L., Sarrazin, Christoph, Miller, Janice S., Welker, Martin W., Forestier, Nicole, Reesink, Hendrik W., Kwong, Ann D., Zeuzem, Stefan

“…Telaprevir (VX‐950) is an orally active, specifically targeted antiviral therapy for hepatitis C virus (HCV) that has been shown to profoundly reduce plasma…”
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Evolution of Treatment-Emergent Resistant Variants in Telaprevir Phase 3 Clinical Trials by Sullivan, James C., De Meyer, Sandra, Bartels, Doug J., Dierynck, Inge, Zhang, Eileen Z., Spanks, Joan, Tigges, Ann M., Ghys, Anne, Dorrian, Jennifer, Adda, Nathalie, Martin, Emily C., Beumont, Maria, Jacobson, Ira M., Sherman, Kenneth E., Zeuzem, Stefan, Picchio, Gaston, Kieffer, Tara L.

“…Background. Telaprevir (TVR), a hepatitis C virus (HCV) NS3/4A protease inhibitor, has been approved to treat genotype 1 HCV. To understand the clinical impact…”
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Hepatitis C Virus Variants with Decreased Sensitivity to Direct-Acting Antivirals (DAAs) Were Rarely Observed in DAA-Naive Patients prior to Treatment by Bartels, Doug J, Sullivan, James C, Zhang, Eileen Z, Tigges, Ann M, Dorrian, Jennifer L, De Meyer, Sandra, Takemoto, Darin, Dondero, Elizabeth, Kwong, Ann D, Picchio, Gaston, Kieffer, Tara L

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Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials by Kieffer, Tara L, De Meyer, Sandra, Bartels, Doug J, Sullivan, James C, Zhang, Eileen Z, Tigges, Ann, Dierynck, Inge, Spanks, Joan, Dorrian, Jennifer, Jiang, Min, Adiwijaya, Bambang, Ghys, Anne, Beumont, Maria, Kauffman, Robert S, Adda, Nathalie, Jacobson, Ira M, Sherman, Kenneth E, Zeuzem, Stefan, Kwong, Ann D, Picchio, Gaston

“…In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased…”
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Natural Prevalence of Hepatitis C Virus Variants with Decreased Sensitivity to NS3·4A Protease Inhibitors in Treatment-Naive Subjects by Bartels, Doug J., Zhou, Yi, Zhang, Eileen Z., Marcial, Michelle, Byrn, Randal A., Pfeiffer, Thomas, Tigges, Ann M., Adiwijaya, Bambang S., Lin, Chao, Kwong, Ann D., Kieffer, Tara L.

“…Background. The prevalence and clinical implications of naturally occurring variants that are resistant to hepatitis C virus (HCV) protease inhibitors in…”
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Antiviral effects and safety of telaprevir, peginterferon alfa-2a, and ribavirin for 28 days in hepatitis C patients by Lawitz, Eric, Rodriguez-Torres, Maribel, Muir, Andrew J, Kieffer, Tara L, McNair, Lindsay, Khunvichai, Ariya, McHutchison, John G

“…Background/Aims This study assessed the safety and antiviral effects of telaprevir (VX-950) in combination with peginterferon alfa-2a and ribavirin. Methods…”
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Deep-Sequencing Analysis of the Gene Encoding the Hepatitis C Virus Nonstructural 3-4A Protease Confirms a Low Prevalence of Telaprevir-Resistant Variants at Baseline and the End of the REALIZE Study by Dierynck, Inge, Thys, Kim, Ghys, Anne, Sullivan, James C., Kieffer, Tara L., Aerssens, Jeroen, Picchio, Gaston, De Meyer, Sandra

“…Background. Population sequencing (PS) has shown that telaprevir-resistant variants are not typically detectable at baseline (prevalence, ≤5% of patients), and…”
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G→A Hypermutation in Protease and Reverse Transcriptase Regions of Human Immunodeficiency Virus Type 1 Residing in Resting CD4+ T Cells In Vivo by Kieffer, Tara L, Kwon, Patty, Nettles, Richard E, Han, Yefei, Ray, Stuart C, Siliciano, Robert F

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In Vitro Phenotypic Characterization of Hepatitis C Virus NS3 Protease Variants Observed in Clinical Studies of Telaprevir by MIN JIANG, MANI, Nagraj, MÜH, Ute, HANZELKA, Brian, TIGGES, Ann, RIJNBRAND, Rene, KIEFFER, Tara L, CHAO LIN, ARDZINSKI, Andrzej, NELSON, Michelle, REAGAN, Dugan, BARTELS, Doug, YI ZHOU, NICOLAS, Olivier, GOVINDA RAO, B

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Genotypic Analysis of HIV-1 Drug Resistance at the Limit of Detection: Virus Production without Evolution in Treated Adults with Undetectable HIV Loads by Kieffer, Tara L., Finucane, Mariel M., Nettles, Richard E., Quinn, Thomas C., Broman, Karl W., Ray, Stuart C., Persaud, Deborah, Siliciano, Robert F.

“…Human immunodeficiency virus (HIV) production continues in patients receiving highly active antiretroviral therapy (HAART) with undetectable (<50 copies/mL)…”
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A viral dynamic model for treatment regimens with direct-acting antivirals for chronic hepatitis C infection by Adiwijaya, Bambang S, Kieffer, Tara L, Henshaw, Joshua, Eisenhauer, Karen, Kimko, Holly, Alam, John J, Kauffman, Robert S, Garg, Varun

“…We propose an integrative, mechanistic model that integrates in vitro virology data, pharmacokinetics, and viral response to a combination regimen of a…”
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Molecular Characterization of Preintegration Latency in Human Immunodeficiency Virus Type 1 Infection by Pierson, Theodore C, Zhou, Yan, Kieffer, Tara L, Ruff, Christian T, Buck, Christopher, Siliciano, Robert F

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Evaluation of persistence of resistant variants with ultra-deep pyrosequencing in chronic hepatitis C patients treated with telaprevir by Thomas, Xiomara V, de Bruijne, Joep, Sullivan, James C, Kieffer, Tara L, Ho, Cynthia K Y, Rebers, Sjoerd P, de Vries, Michel, Reesink, Hendrik W, Weegink, Christine J, Molenkamp, Richard, Schinkel, Janke

“…Telaprevir, a hepatitis C virus NS3/4A protease inhibitor has significantly improved sustained viral response rates when given in combination with pegylated…”
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Marked Intraindividual Variability in Antiretroviral Concentrations May Limit the Utility of Therapeutic Drug Monitoring by Nettles, Richard E., Kieffer, Tara L., Parsons, Teresa, Johnson, James, Cofrancesco, Joseph, Gallant, Joel E., Carson, Kathryn A., Siliciano, Robert F., Flexner, Charles

“…Background. Effective therapeutic drug monitoring for antiretrovirals requires a better understanding of intraindividual variability in pharmacokinetics…”
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Modeling viral evolutionary dynamics after telaprevir-based treatment by Haseltine, Eric L, De Meyer, Sandra, Dierynck, Inge, Bartels, Doug J, Ghys, Anne, Davis, Andrew, Zhang, Eileen Z, Tigges, Ann M, Spanks, Joan, Picchio, Gaston, Kieffer, Tara L, Sullivan, James C

“…For patients infected with hepatitis C virus (HCV), the combination of the direct-acting antiviral agent telaprevir, pegylated-interferon alfa (Peg-IFN), and…”
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Development of a sensitive RT-PCR method for amplifying and sequencing near full-length HCV genotype 1 RNA from patient samples by Zhang, Eileen Z, Bartels, Doug J, Frantz, J Dan, Seepersaud, Sheila, Lippke, Judith A, Shames, Benjamin, Zhou, Yi, Lin, Chao, Kwong, Ann, Kieffer, Tara L

“…BACKGROUND: Direct-acting antiviral (DAAs) agents for hepatitis C virus (HCV) span a variety of targets, including proteins encoded by the NS3/4A, NS4B, NS5A,…”
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Intrinsic Stability of Episomal Circles Formed during Human Immunodeficiency Virus Type 1 Replication by Pierson, Theodore C, Kieffer, Tara L, Ruff, Christian T, Buck, Christopher, Gange, Stephen J, Siliciano, Robert F

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Genotypic Resistance in HIV-1—Infected Patients with Persistently Detectable Low-Level Viremia while Receiving Highly Active Antiretroviral Therapy by Nettles, Richard E., Kieffer, Tara L., Simmons, Rachel P., Cofrancesco, Joseph, Moore, Richard D., Gallant, Joel E., Persaud, Deborah, Siliciano, Robert F.

“…Background. Technical limitations in the sensitivity of commercial genotyping methods may prevent clinicians from determining whether drug-resistant human…”
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Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection by Jacobson, Ira M, McHutchison, John G, Dusheiko, Geoffrey, Di Bisceglie, Adrian M, Reddy, K. Rajender, Bzowej, Natalie H, Marcellin, Patrick, Muir, Andrew J, Ferenci, Peter, Flisiak, Robert, George, Jacob, George, Shelley, Rizzetto, Mario, Shouval, Daniel, Sola, Ricard, Terg, Ruben A, Yoshida, Eric M, Adda, Nathalie, Bengtsson, Leif, Sankoh, Abdul J, Kieffer, Tara L, Kauffman, Robert S, M.D, Stefan Zeuzem

“…In patients with HCV infection and no previous treatment, the addition of telaprevir to peginterferon–ribavirin resulted in higher response rates than those…”
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In Vivo Clearance of an Intracellular Bacterium, Francisella tularensis LVS, Is Dependent on the p40 Subunit of Interleukin-12 (IL-12) but Not on IL-12 p70 by ELKINS, Karen L, COOPER, Allison, COLOMBINI, Susan M, COWLEY, Siobhan C, KIEFFER, Tara L

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