Search Results - "Kieffer, Dorothy A"

High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease by Vaziri, Nosratola D, Liu, Shu-Man, Lau, Wei Ling, Khazaeli, Mahyar, Nazertehrani, Sohrab, Farzaneh, Seyed H, Kieffer, Dorothy A, Adams, Sean H, Martin, Roy J

“…Inflammation is a major mediator of CKD progression and is partly driven by altered gut microbiome and intestinal barrier disruption, events which are caused…”
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Impact of Dietary Fibers on Nutrient Management and Detoxification Organs: Gut, Liver, and Kidneys by Kieffer, Dorothy A, Martin, Roy J, Adams, Sean H

“…Increased dietary fiber (DF) intake elicits a wide range of physiologic effects, not just locally in the gut, but systemically. DFs can greatly alter the gut…”
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Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity by Lackey, Denise E, Lynch, Christopher J, Olson, Kristine C, Mostaedi, Rouzbeh, Ali, Mohamed, Smith, William H, Karpe, Fredrik, Humphreys, Sandy, Bedinger, Daniel H, Dunn, Tamara N, Thomas, Anthony P, Oort, Pieter J, Kieffer, Dorothy A, Amin, Rajesh, Bettaieb, Ahmed, Haj, Fawaz G, Permana, Paska, Anthony, Tracy G, Adams, Sean H

“…Elevated blood branched-chain amino acids (BCAA) are often associated with insulin resistance and type 2 diabetes, which might result from a reduced cellular…”
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Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats by Zybailov, Boris L, Glazko, Galina V, Rahmatallah, Yasir, Andreyev, Dmitri S, McElroy, Taylor, Karaduta, Oleg, Byrum, Stephanie D, Orr, Lisa, Tackett, Alan J, Mackintosh, Samuel G, Edmondson, Ricky D, Kieffer, Dorothy A, Martin, R J, Adams, Sean H, Vaziri, Nosratola D, Arthur, John M

“…Resistant starch is a prebiotic metabolized by the gut bacteria. It has been shown to attenuate chronic kidney disease (CKD) progression in rats. Previous…”
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Wilson disease: At the crossroads between genetics and epigenetics—A review of the evidence by Kieffer, Dorothy A., Medici, Valentina

“…Environmental factors, including diet, exercise, stress, and toxins, profoundly impact disease phenotypes. This review examines how Wilson disease (WD), an…”
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Hepatocellular Carcinoma and Associated Clinical Features in Latino and Caucasian Patients from a Single Center by Kuftinec, Gabriela N, Levy, Robert, Kieffer, Dorothy A, Medici, Valentina

“…AbstractIntroduction and aimHepatocellular carcinoma (HCC) is the most common type of liver cancer in adults and has seen a rapid increase in incidence in the…”
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Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers by Mordaunt, Charles E, Kieffer, Dorothy A, Shibata, Noreene M, Członkowska, Anna, Litwin, Tomasz, Weiss, Karl-Heinz, Zhu, Yihui, Bowlus, Christopher L, Sarkar, Souvik, Cooper, Stewart, Wan, Yu-Jui Yvonne, Ali, Mohamed R, LaSalle, Janine M, Medici, Valentina

“…Wilson disease (WD) is an autosomal recessive disease caused by mutations in ATP7B encoding a copper transporter. Consequent copper accumulation results in a…”
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Plasma Oxylipin Profile Discriminates Ethnicities in Subjects with Non-Alcoholic Steatohepatitis: An Exploratory Analysis by Mazi, Tagreed A, Borkowski, Kamil, Fiehn, Oliver, Bowlus, Christopher L, Sarkar, Souvik, Matsukuma, Karen, Ali, Mohamed R, Kieffer, Dorothy A, Wan, Yu-Jui Y, Stanhope, Kimber L, Havel, Peter J, Newman, John W, Medici, Valentina

“…Non-alcoholic fatty liver disease (NAFLD) is a common liver pathology that includes steatosis, or non-alcoholic fatty liver (NAFL), and non-alcoholic…”
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Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats by Kieffer, Dorothy A, Piccolo, Brian D, Vaziri, Nosratola D, Liu, Shuman, Lau, Wei L, Khazaeli, Mahyar, Nazertehrani, Sohrab, Moore, Mary E, Marco, Maria L, Martin, Roy J, Adams, Sean H

“…Patients and animals with chronic kidney disease (CKD) exhibit profound alterations in the gut environment including shifts in microbial composition, increased…”
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Ethnicity-specific alterations of plasma and hepatic lipidomic profiles are related to high NAFLD rate and severity in Hispanic Americans, a pilot study by Mazi, Tagreed A., Borkowski, Kamil, Newman, John W., Fiehn, Oliver, Bowlus, Christopher L., Sarkar, Souvik, Matsukuma, Karen, Ali, Mohamed R., Kieffer, Dorothy A., Wan, Yu-Jui Y., Stanhope, Kimber L., Havel, Peter J., Medici, Valentina

“…Nonalcoholic fatty liver disease (NAFLD) is a progressive condition that includes steatosis (NAFL) and nonalcoholic steatohepatitis (NASH). In the U.S.,…”
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Mice Fed a High-Fat Diet Supplemented with Resistant Starch Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria by Kieffer, Dorothy A, Piccolo, Brian D, Marco, Maria L, Kim, Eun Bae, Goodson, Michael L, Keenan, Michael J, Dunn, Tamara N, Knudsen, Knud Erik Bach, Martin, Roy J, Adams, Sean H

“…High-amylose-maize resistant starch type 2 (HAMRS2) is a fermentable dietary fiber known to alter the gut milieu, including the gut microbiota, which may…”
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Metabolomics profiles of patients with Wilson disease reveal a distinct metabolic signature by Sarode, Gaurav V., Kim, Kyoungmi, Kieffer, Dorothy A., Shibata, Noreene M., Litwin, Tomas, Czlonkowska, Anna, Medici, Valentina

“…Introduction Wilson disease (WD) is characterized by excessive intracellular copper accumulation in liver and brain due to defective copper biliary excretion…”
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Effects of obesity, energy restriction and neutering on the faecal microbiota of cats by Fischer, Manuela M., Kessler, Alexandre M., Kieffer, Dorothy A., Knotts, Trina A., Kim, Kyoungmi, Wei, Alfreda, Ramsey, Jon J., Fascetti, Andrea J.

“…Surveys report that 25–57 % of cats are overweight or obese. The most evinced cause is neutering. Weight loss often fails; thus, new strategies are needed…”
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Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease by Mordaunt, Charles E, Shibata, Noreene M, Kieffer, Dorothy A, Członkowska, Anna, Litwin, Tomasz, Weiss, Karl Heinz, Gotthardt, Daniel N, Olson, Kristin, Wei, Dongguang, Cooper, Stewart, Wan, Yu-Jui Yvonne, Ali, Mohamed R, LaSalle, Janine M, Medici, Valentina

“…Abstract Wilson disease (WD) is caused by mutations in the copper transporter ATP7B, leading to copper accumulation in the liver and brain. Excess copper…”
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mtDNA depletion‐like syndrome in Wilson disease by Medici, Valentina, Sarode, Gaurav V., Napoli, Eleonora, Song, Gyu‐Young, Shibata, Noreene M., Guimarães, Andre O., Mordaunt, Charles E., Kieffer, Dorothy A., Mazi, Tagreed A., Czlonkowska, Anna, Litwin, Tomasz, LaSalle, Janine M., Giulivi, Cecilia

“…Background and Aims Wilson disease (WD) is caused by mutations in the copper transporter ATP7B, with its main pathology attributed to copper‐mediated oxidative…”
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Obese Mice Fed a Diet Supplemented with Enzyme-Treated Wheat Bran Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria by Kieffer, Dorothy A, Piccolo, Brian D, Marco, Maria L, Kim, Eun Bae, Goodson, Michael L, Keenan, Michael J, Dunn, Tamara N, Knudsen, Knud Erik Bach, Adams, Sean H, Martin, Roy J

“…Enzyme-treated wheat bran (ETWB) contains a fermentable dietary fiber previously shown to decrease liver triglycerides (TGs) and modify the gut microbiome in…”
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Correction to: Metabolomics profiles of patients with Wilson disease reveal a distinct metabolic signature by Sarode, Gaurav V., Kim, Kyoungmi, Kieffer, Dorothy A., Shibata, Noreene M., Litwin, Tomas, Czlonkowska, Anna, Medici, Valentina

“…In the originally published version of this article, there was an error. The metabolomics platform used for the analysis is GC-TOF-MS, Gas Chromatography…”
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Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model by Medici, Valentina, Kieffer, Dorothy A., Shibata, Noreene M., Chima, Harpreet, Kim, Kyoungmi, Canovas, Angela, Medrano, Juan F., Islas-Trejo, Alma D., Kharbanda, Kusum K., Olson, Kristin, Su, Ruijun J., Islam, Mohammad S., Syed, Raisa, Keen, Carl L., Miller, Amy Y., Rutledge, John C., Halsted, Charles H., LaSalle, Janine M.

“…Wilson disease (WD), a genetic disorder affecting copper transport, is characterized by hepatic and neurological manifestations with variable and often…”
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Acute Treatment With XMetA Activates Hepatic Insulin Receptors and Lowers Blood Glucose in Normal Mice by Bedinger, Daniel H., Kieffer, Dorothy A., Goldfine, Ira D., Roell, Marina K., Adams, Sean H.

“…ABSTRACT It has been proposed that monoclonal antibodies may become therapeutics for metabolic diseases such as diabetes mellitus. We have previously…”
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Hepatocellular Carcinoma and Associated Clinical Features in Latino and Caucasian Patients from a Single Center by Kuftinec, Gabriela N, Levy, Robert, Kieffer, Dorothy A, Medici, Valentina

“…Hepatocellular carcinoma (HCC) is the most common type of liver cancer in adults and has seen a rapid increase in incidence in the United States. Racial and…”
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