Search Results - "Kieffer, Collin"

Deletion of Intestinal SHP Impairs Short-term Response to Cholic Acid Challenge in Male Mice by Nguyen, James T, Riessen, Ryan, Zhang, Tongyu, Kieffer, Collin, Anakk, Sayeepriyadarshini

“…Abstract Small heterodimer partner (SHP) is a crucial regulator of bile acid (BA) transport and synthesis; however, its intestine-specific role is not fully…”
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Mechanisms of virus dissemination in bone marrow of HIV-1-infected humanized BLT mice by Ladinsky, Mark S, Khamaikawin, Wannisa, Jung, Yujin, Lin, Samantha, Lam, Jennifer, An, Dong Sung, Bjorkman, Pamela J, Kieffer, Collin

“…Immune progenitor cells differentiate in bone marrow (BM) and then migrate to tissues. HIV-1 infects multiple BM cell types, but virus dissemination within BM…”
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High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike by Tan, Timothy J. C., Mou, Zongjun, Lei, Ruipeng, Ouyang, Wenhao O., Yuan, Meng, Song, Ge, Andrabi, Raiees, Wilson, Ian A., Kieffer, Collin, Dai, Xinghong, Matreyek, Kenneth A., Wu, Nicholas C.

“…Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-19 vaccines. All COVID-19 vaccines in the US encode spike with…”
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Longitudinal imaging of HIV-1 spread in humanized mice with parallel 3D immunofluorescence and electron tomography by Kieffer, Collin, Ladinsky, Mark S, Ninh, Allen, Galimidi, Rachel P, Bjorkman, Pamela J

“…Dissemination of HIV-1 throughout lymphoid tissues leads to systemic virus spread following infection. We combined tissue clearing, 3D-immunofluorescence, and…”
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Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice by Ventura, John D, Beloor, Jagadish, Allen, Edward, Zhang, Tongyu, Haugh, Kelsey A, Uchil, Pradeep D, Ochsenbauer, Christina, Kieffer, Collin, Kumar, Priti, Hope, Thomas J, Mothes, Walther

“…Non-invasive bioluminescent imaging (NIBLI) of HIV-1 infection dynamics allows for real-time monitoring of viral spread and the localization of infected cell…”
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Electron cryotomography of immature HIV-1 virions reveals the structure of the CA and SP1 Gag shells by Wright, Elizabeth R, Schooler, Jordan B, Ding, H Jane, Kieffer, Collin, Fillmore, Christopher, Sundquist, Wesley I, Jensen, Grant J

“…The major structural elements of retroviruses are contained in a single polyprotein, Gag, which in human immunodeficiency virus type 1 (HIV‐1) comprises the…”
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Two Distinct Modes of ESCRT-III Recognition Are Required for VPS4 Functions in Lysosomal Protein Targeting and HIV-1 Budding by Kieffer, Collin, Skalicky, Jack J., Morita, Eiji, De Domenico, Ivana, Ward, Diane M., Kaplan, Jerry, Sundquist, Wesley I.

“…The ESCRT pathway mediates membrane remodeling during enveloped virus budding, cytokinesis, and intralumenal endosomal vesicle formation. Late in the pathway,…”
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In vitro characterization of engineered red blood cells as viral traps against HIV-1 and SARS-CoV-2 by Hoffmann, Magnus A.G., Kieffer, Collin, Bjorkman, Pamela J.

“…Engineered red blood cells (RBCs) expressing viral receptors could be used therapeutically as viral traps, as RBCs lack nuclei and other organelles required…”
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Electron tomography of HIV-1 infection in gut-associated lymphoid tissue by Ladinsky, Mark S, Kieffer, Collin, Olson, Gregory, Deruaz, Maud, Vrbanac, Vladimir, Tager, Andrew M, Kwon, Douglas S, Bjorkman, Pamela J

“…Critical aspects of HIV-1 infection occur in mucosal tissues, particularly in the gut, which contains large numbers of HIV-1 target cells that are depleted…”
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Dioxin exposure blocks lactation through a direct effect on mammary epithelial cells mediated by the aryl hydrocarbon receptor repressor by Basham, Kaitlin J, Leonard, Christopher J, Kieffer, Collin, Shelton, Dawne N, McDowell, Maria E, Bhonde, Vasudev R, Looper, Ryan E, Welm, Bryan E

“…In mammals, lactation is a rich source of nutrients and antibodies for newborn animals. However, millions of mothers each year experience an inability to…”
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Chemical Genetic Screen Reveals a Role for Desmosomal Adhesion in Mammary Branching Morphogenesis by Basham, Kaitlin J., Kieffer, Collin, Shelton, Dawne N., Leonard, Christopher J., Bhonde, Vasudev R., Vankayalapati, Hariprasad, Milash, Brett, Bearss, David J., Looper, Ryan E., Welm, Bryan E.

“…During the process of branching morphogenesis, the mammary gland undergoes distinct phases of remodeling to form an elaborate ductal network that ultimately…”
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Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor by Basham, Kaitlin J., Bhonde, Vasudev R., Kieffer, Collin, Mack, James B.C., Hess, Matthew, Welm, Bryan E., Looper, Ryan E.

“…Bis-aryloxadiazoles are common scaffolds in medicinal chemistry due to their wide range of biological activities. Previously, we identified a…”
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Biochemical and Structural Studies of Yeast Vps4 Oligomerization by Gonciarz, Malgorzata D., Whitby, Frank G., Eckert, Debra M., Kieffer, Collin, Heroux, Annie, Sundquist, Wesley I., Hill, Christopher P.

“…The ESCRT (endosomal sorting complexes required for transport) pathway functions in vesicle formation at the multivesicular body, the budding of enveloped RNA…”
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Exploiting the Enzymatic Recognition of an Unnatural Base Pair to Develop a Universal Genetic Analysis System by Moser, Michael J, Marshall, David J, Grenier, Jennifer K, Kieffer, Collin D, Killeen, Anthony A, Ptacin, Jerod L, Richmond, Craig S, Roesch, Eric B, Scherrer, Christopher W, Sherrill, Christopher B, Van Hout, Cris V, Zanton, Sara J, Prudent, James R

“…With the invention of the DNA chip, genome-wide analysis is now a reality. Unfortunately, solid-phase detection systems such as the DNA chip suffer from a…”
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Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation by Blanco, Alexandra, Coronado, Robert A, Arun, Neha, Ma, Kelly, Dar, Roy D, Kieffer, Collin

“…HIV latency regulation in monocytes and macrophages can vary according to signals directing differentiation, polarization, and function. To investigate these…”
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ESCRT-III recognition by VPS4 ATPases by STUCHELL-BRERETON, Melissa D, SKALICKY, Jack J, KIEFFER, Collin, KARREN, Mary Anne, GHAFFARIAN, Sanaz, SUNDQUIST, Wesley I

“…The ESCRT (endosomal sorting complex required for transport) pathway is required for terminal membrane fission events in several important biological…”
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3D Visualization of Immune Cell Populations in HIV-Infected Tissues via Clearing, Immunostaining, Confocal, and Light Sheet Fluorescence Microscopy by Zhang, Tongyu, Gupta, Auroni, Frederick, Deborah, Layman, Laura, Smith, Davey M, Gianella, Sara, Kieffer, Collin

“…Human Immunodeficiency Virus (HIV), the causative agent of Acquired Immune Deficiency Syndrome (AIDS), is a major global health concern with nearly 40 million…”
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Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning by Ouyang, Wenhao O, Tan, Timothy J C, Lei, Ruipeng, Song, Ge, Kieffer, Collin, Andrabi, Raiees, Matreyek, Kenneth A, Wu, Nicholas C

“…Increasing the expression level of the SARS-CoV-2 spike (S) protein has been critical for COVID-19 vaccine development. While previous efforts largely focused…”
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Electron Tomography of HIV-1 Infection in Gut-Associated Lymphoid Tissue: e1003899 by Ladinsky, Mark S, Kieffer, Collin, Olson, Gregory, Deruaz, Maud, Vrbanac, Vladimir, Tager, Andrew M, Kwon, Douglas S, Bjorkman, Pamela J

“…Critical aspects of HIV-1 infection occur in mucosal tissues, particularly in the gut, which contains large numbers of HIV-1 target cells that are depleted…”
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Targeting the PyMT Oncogene to Diverse Mammary Cell Populations Enhances Tumor Heterogeneity and Generates Rare Breast Cancer Subtypes by Smith, Brittni A, Shelton, Dawne N, Kieffer, Collin, Milash, Brett, Usary, Jerry, Perou, Charles M, Bernard, Philip S, Welm, Bryan E

“…Human breast cancer is a heterogeneous disease composed of different histologies and molecular subtypes, many of which are not replicated in animal models…”
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