Search Results - "Kiebler, A"

RNA-binding proteins balance brain function in health and disease by Schieweck, Rico, Ninkovic, Jovica, Kiebler, Michael A.

“…Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA decay provides an important regulatory layer in many if not all…”
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Mechanisms of dendritic mRNA transport and its role in synaptic tagging by Doyle, Michael, Kiebler, Michael A

“…The localization of RNAs critically contributes to many important cellular processes in an organism, such as the establishment of polarity, asymmetric division…”
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The multifunctional Staufen proteins: conserved roles from neurogenesis to synaptic plasticity by Heraud-Farlow, Jacki E, Kiebler, Michael A

“…Highlights • Staufen (Stau) proteins have evolutionarily conserved functions in the brain. • Stau proteins asymmetrically segregate mRNAs during mouse and fly…”
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RNA supply drives physiological granule assembly in neurons by Bauer, Karl E., Bargenda, Niklas, Schieweck, Rico, Illig, Christin, Segura, Inmaculada, Harner, Max, Kiebler, Michael A.

“…Membraneless cytoplasmic condensates of mRNAs and proteins, known as RNA granules, play pivotal roles in the regulation of mRNA fate. Their maintenance…”
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An Asymmetrically Localized Staufen2-Dependent RNA Complex Regulates Maintenance of Mammalian Neural Stem Cells by Vessey, John P., Amadei, Gianluca, Burns, Sarah E., Kiebler, Michael A., Kaplan, David R., Miller, Freda D.

“…The cellular mechanisms that regulate self-renewal versus differentiation of mammalian somatic tissue stem cells are still largely unknown. Here, we asked…”
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mTOR and MAPK: from localized translation control to epilepsy by Pernice, Helena F, Schieweck, Rico, Kiebler, Michael A, Popper, Bastian

“…Epilepsy is one of the most common neurological diseases characterized by excessive hyperexcitability of neurons. Molecular mechanisms of epilepsy are diverse…”
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Synaptically-targeted long non-coding RNA SLAMR promotes structural plasticity by increasing translation and CaMKII activity by Espadas, Isabel, Wingfield, Jenna L., Nakahata, Yoshihisa, Chanda, Kaushik, Grinman, Eddie, Ghosh, Ilika, Bauer, Karl E., Raveendra, Bindu, Kiebler, Michael A., Yasuda, Ryohei, Rangaraju, Vidhya, Puthanveettil, Sathyanarayanan

“…Long noncoding RNAs (lncRNAs) play crucial roles in maintaining cell homeostasis and function. However, it remains largely unknown whether and how neuronal…”
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Posttranscriptional Gene Regulation of the GABA Receptor to Control Neuronal Inhibition by Schieweck, Rico, Kiebler, Michael A

“…Behavior and higher cognition rely on the transfer of information between neurons through specialized contact sites termed synapses. Plasticity of neuronal…”
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Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses by Bauer, Karl E., Segura, Inmaculada, Gaspar, Imre, Scheuss, Volker, Illig, Christin, Ammer, Georg, Hutten, Saskia, Basyuk, Eugénia, Fernández-Moya, Sandra M., Ehses, Janina, Bertrand, Edouard, Kiebler, Michael A.

“…mRNA transport restricts translation to specific subcellular locations, which is the basis for many cellular functions. However, the precise process of mRNA…”
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The GTP-Binding Protein Septin 7 Is Critical for Dendrite Branching and Dendritic-Spine Morphology by Xie, Yunli, Vessey, John P., Konecna, Anetta, Dahm, Ralf, Macchi, Paolo, Kiebler, Michael A.

“…Septins, a highly conserved family of GTP-binding proteins, were originally identified in a genetic screen for S. cerevisiae mutants defective in cytokinesis…”
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Interactome of Two Diverse RNA Granules Links mRNA Localization to Translational Repression in Neurons by Fritzsche, Renate, Karra, Daniela, Bennett, Keiryn L., Ang, Foong yee, Heraud-Farlow, Jacki E., Tolino, Marco, Doyle, Michael, Bauer, Karl E., Thomas, Sabine, Planyavsky, Melanie, Arn, Eric, Bakosova, Anetta, Jungwirth, Kerstin, Hörmann, Alexandra, Palfi, Zsofia, Sandholzer, Julia, Schwarz, Martina, Macchi, Paolo, Colinge, Jacques, Superti-Furga, Giulio, Kiebler, Michael A.

“…Transport of RNAs to dendrites occurs in neuronal RNA granules, which allows local synthesis of specific proteins at active synapses on demand, thereby…”
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Fear extinction is regulated by the activity of long noncoding RNAs at the synapse by Liau, Wei-Siang, Zhao, Qiongyi, Bademosi, Adekunle, Gormal, Rachel S., Gong, Hao, Marshall, Paul R., Periyakaruppiah, Ambika, Madugalle, Sachithrani U., Zajaczkowski, Esmi L., Leighton, Laura J., Ren, Haobin, Musgrove, Mason, Davies, Joshua, Rauch, Simone, He, Chuan, Dickinson, Bryan C., Li, Xiang, Wei, Wei, Meunier, Frédéric A., Fernández-Moya, Sandra M., Kiebler, Michael A., Srinivasan, Balakumar, Banerjee, Sourav, Clark, Michael, Spitale, Robert C., Bredy, Timothy W.

“…Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules that are involved in many aspects of brain function. Emerging evidence…”
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Meet the players: local translation at the synapse by Fernandez-Moya, Sandra M, Bauer, Karl E, Kiebler, Michael A

“…It is widely believed that activity-dependent synaptic plasticity is the basis for learning and memory. Both processes are dependent on new protein synthesis…”
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Pumilio2 Promotes Growth of Mature Neurons by Schieweck, Rico, Schöneweiss, Elisa-Charlott, Harner, Max, Rieger, Daniela, Illig, Christin, Saccà, Barbara, Popper, Bastian, Kiebler, Michael A.

“…RNA-binding proteins (RBPs) are essential regulators controlling both the cellular transcriptome and translatome. These processes enable cellular plasticity,…”
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Staufen2 Regulates Neuronal Target RNAs by Heraud-Farlow, Jacki E., Sharangdhar, Tejaswini, Li, Xiao, Pfeifer, Philipp, Tauber, Stefanie, Orozco, Denise, Hörmann, Alexandra, Thomas, Sabine, Bakosova, Anetta, Farlow, Ashley R., Edbauer, Dieter, Lipshitz, Howard D., Morris, Quaid D., Bilban, Martin, Doyle, Michael, Kiebler, Michael A.

“…RNA-binding proteins play crucial roles in directing RNA translation to neuronal synapses. Staufen2 (Stau2) has been implicated in both dendritic RNA…”
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Altered Glutamate Receptor Ionotropic Delta Subunit 2 Expression in Stau2-Deficient Cerebellar Purkinje Cells in the Adult Brain by Pernice, Helena F, Schieweck, Rico, Jafari, Mehrnoosh, Straub, Tobias, Bilban, Martin, Kiebler, Michael A, Popper, Bastian

“…Staufen2 (Stau2) is an RNA-binding protein that is involved in dendritic spine morphogenesis and function. Several studies have recently investigated the role…”
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Dendritic Localization of the Translational Repressor Pumilio 2 and Its Contribution to Dendritic Stress Granules by Vessey, John P, Vaccani, Angelo, Xie, Yunli, Dahm, Ralf, Karra, Daniela, Kiebler, Michael A, Macchi, Paolo

“…Pumilio (Pum) protein acts as a translational inhibitor in several organisms including yeast, Drosophila, Xenopus, and mammals. Two Pumilio genes, Pum1 and…”
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Physical Activity Dynamically Regulates the Hippocampal Proteome along the Dorso-Ventral Axis by Frey, Surina, Schieweck, Rico, Forné, Ignasi, Imhof, Axel, Straub, Tobias, Popper, Bastian, Kiebler, Michael A

“…The hippocampus is central for higher cognition and emotions. In patients suffering from neuropsychiatric or neurodegenerative diseases, hippocampal signaling…”
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Pumilio2-deficient mice show a predisposition for epilepsy by Follwaczny, Philipp, Schieweck, Rico, Riedemann, Therese, Demleitner, Antonia, Straub, Tobias, Klemm, Anna H, Bilban, Martin, Sutor, Bernd, Popper, Bastian, Kiebler, Michael A

“…Epilepsy is a neurological disease that is caused by abnormal hypersynchronous activities of neuronal ensembles leading to recurrent and spontaneous seizures…”
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Forebrain-specific, conditional silencing of Staufen2 alters synaptic plasticity, learning, and memory in rats by Berger, Stefan M, Fernández-Lamo, Iván, Schönig, Kai, Fernández Moya, Sandra M, Ehses, Janina, Schieweck, Rico, Clementi, Stefano, Enkel, Thomas, Grothe, Sascha, von Bohlen Und Halbach, Oliver, Segura, Inmaculada, Delgado-García, José María, Gruart, Agnès, Kiebler, Michael A, Bartsch, Dusan

“…Dendritic messenger RNA (mRNA) localization and subsequent local translation in dendrites critically contributes to synaptic plasticity and learning and…”
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