Interleukin -1beta (IL-1 beta), interleukin 6 (IL-6) and tumor necrosis factor (TNF) in plasma and pleural fluid of pneumonia, lung cancer and tuberculous pleuritis

Interleukins IL-1beta, IL-6 and TNF are increased in plasma of patients with severe infections and septic shock. Our objective was the evaluation of IL-1beta, IL-6 and TNF in plasma and exudates of pleural fluid and their contribution to the diagnosis. We studied 44 patients, 27 men and 17 women wit...

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Bibliographic Details
Published in:	Journal of biological regulators and homeostatic agents Vol. 20; no. 1-2; p. 41
Main Authors:	Ilonidis, G, Parapanisiou, E, Anogeianaki, A, Giavazis, I, Theofilogiannakos, E K, Tsekoura, P, Kidonopoulou, K, Trakatelli, Chr, Polimenidis, Z, Conti, P, Anogianakis, G
Format:	Journal Article
Language:	English
Published:	Italy 01-01-2006
Subjects:	Adult Aged Aged, 80 and over Female Humans Interleukin-1beta - metabolism Interleukin-6 - metabolism Lung Neoplasms - metabolism Male Middle Aged Pneumococcal Infections - metabolism Tuberculosis, Pleural - metabolism Tumor Necrosis Factor-alpha - metabolism
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Summary:	Interleukins IL-1beta, IL-6 and TNF are increased in plasma of patients with severe infections and septic shock. Our objective was the evaluation of IL-1beta, IL-6 and TNF in plasma and exudates of pleural fluid and their contribution to the diagnosis. We studied 44 patients, 27 men and 17 women with mean age 66.81 +/- 11.75 years; 16 with pneumonia and parapneumonic effusion, 14 with primary lung cancer and pleural effusion and 14 with tuberculous pleuritis. We measured IL-1beta, IL-6 and TNF in serum and pleural fluid with ELISA. In patients with pneumonia and parapneumonic effusion the mean value of IL-1beta IL-6 and TNF in plasma was 9.05, 19.24 and 21.34 pg/ml and in pleural fluid 10.34, 32.19 and 25.30 pg/ml. In patients with lung cancer the mean values of IL-1beta, IL-6 and TNF were 5.33, 11.74 and 11.51 pg/ml and 6.70, 13.13, 20.89 pg/ml, respectively. In those with tuberculous pleuritis the respective mean values were 10.33, 49.94, 21.27 pg/ml and 14, 56.59, 23.58 pg/ml. In conclusion, IL-1beta and IL-6 were found increased in plasma and tuberculous pleural fluid, indicating an inflammatory status.
ISSN:	0393-974X