Search Results - "Kida, Sachiho"

Evaluation of cerebrospinal fluid heparan sulfate as a biomarker of neuropathology in a murine model of mucopolysaccharidosis type II using high-sensitivity LC/MS/MS by Tanaka, Noboru, Kida, Sachiho, Kinoshita, Masafumi, Morimoto, Hideto, Shibasaki, Tadao, Tachibana, Katsuhiko, Yamamoto, Ryuji

“…Mucopolysaccharidosis type II (MPS II or Hunter syndrome) is a lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase (IDS), an enzyme that…”
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Clearance of heparan sulfate in the brain prevents neurodegeneration and neurocognitive impairment in MPS II mice by Morimoto, Hideto, Kida, Sachiho, Yoden, Eiji, Kinoshita, Masafumi, Tanaka, Noboru, Yamamoto, Ryuji, Koshimura, Yuri, Takagi, Haruna, Takahashi, Kenichi, Hirato, Tohru, Minami, Kohtaro, Sonoda, Hiroyuki

“…Mucopolysaccharidosis II (MPS II), a lysosomal storage disease caused by mutations in iduronate-2-sulfatase (IDS), is characterized by a wide variety of…”
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Autophagy in the Central Nervous System and Effects of Chloroquine in Mucopolysaccharidosis Type II Mice by Maeda, Mitsuyo, Seto, Toshiyuki, Kadono, Chiho, Morimoto, Hideto, Kida, Sachiho, Suga, Mitsuo, Nakamura, Motohiro, Kataoka, Yosky, Hamazaki, Takashi, Shintaku, Haruo

“…Mucopolysaccharidosis type II (MPS II) is a rare lysosomal storage disease (LSD) involving a genetic error in iduronic acid-2-sulfatase (IDS) metabolism that…”
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Enzyme replacement with transferrin receptor-targeted α-L-iduronidase rescues brain pathology in mucopolysaccharidosis I mice by Kida, Sachiho, Koshimura, Yuri, Yoden, Eiji, Yoshioka, Aya, Morimoto, Hideto, Imakiire, Atsushi, Tanaka, Noboru, Tanaka, Satowa, Mori, Ayaka, Ito, Jun, Inoue, Asuka, Yamamoto, Ryuji, Minami, Kohtaro, Hirato, Tohru, Takahashi, Kenichi, Sonoda, Hiroyuki

“…Mucopolysaccharidosis I (MPS I), a lysosomal storage disease caused by dysfunction of α-L-iduronidase (IDUA), is characterized by the deposition of dermatan…”
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Ectopic expression of N-acetylglucosaminyltransferase V accelerates hepatic triglyceride synthesis by Kamada, Yoshihiro, Ebisutani, Yusuke, Kida, Sachiho, Mizutani, Kayo, Akita, Maaya, Yamamoto, Akiko, Fujii, Hironobu, Sobajima, Tomoaki, Terao, Naoko, Takamatsu, Shinji, Yoshida, Yuichi, Takehara, Tetsuo, Miyoshi, Eiji

“…Aim Glycosylation changes induce various types of biological phenomena in human diseases. N‐Acetylglucosaminyltransferase V (GnT‐V) is one of the most…”
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Enzyme replacement with a blood-brain barrier-penetrating antibody-fused alfa-L-iduronidase prevents neurobehavioral performance of mucopolysaccharidosis type I mice by Morimoto, Hideto, Kida, Sachiho, Minami, Kohtaro

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A fusion protein of anti-human transferrin receptor antibody and alfa-L-fucosidase 1 is a prospective candidate for the treatment of the symptoms in CNS and visceral tissues of fucosidosis by Yoden, Eiji, Onouchi, Takashi, Fujiyama, Saki, Kida, Sachiho, Hashimoto, Hidehiko, Machida, Wataru, Tanaka, Noboru, Morimoto, Hideto, Shibasaki, Tadao, Minami, Kohtaro, Hirato, Tohru, Sonoda, Hiroyuki, Takahashi, Kenichi

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Nonclinical pharmacodynamics, pharmacokinetics and safety profiles of anti-human transferrin receptor antibody-fused N-sulfoglucosamine sulfohydrolase for mucopolysaccharidosis type IIIA by Inoue, Asuka, Ito, Jun, Kida, Sachiho, Imakiire, Atsushi, Miyauchi, Kazuki, Koshimura, Yuri, Kakimoto, Shinji, Morimoto, Hideto, Yamamoto, Ryuji, Minami, Kohtaro, Hirato, Tohru, Sonoda, Hiroyuki

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Efficacy of an anti-human transferrin receptor antibody-fused N-sulfoglucosamine sulfohydrolase in mucopolysaccharidosis type IIIA mice by Inoue, Asuka, Tanaka, Satowa, Kida, Sachiho, Koshimura, Yuri, Kakimoto, Shinji, Imakiire, Atsushi, Ito, Jun, Miyauchi, Kazuki, Morimoto, Hideto, Minami, Kohtaro, Hirato, Tohru, Sonoda, Hiroyuki

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Fetuin-A negatively correlates with liver and vascular fibrosis in nonalcoholic fatty liver disease subjects by Sato, Motoya, Kamada, Yoshihiro, Takeda, Yuri, Kida, Sachiho, Ohara, Yuka, Fujii, Hironobu, Akita, Maaya, Mizutani, Kayo, Yoshida, Yuichi, Yamada, Makoto, Hougaku, Hidetaka, Takehara, Tetsuo, Miyoshi, Eiji

“…Background & Aims Fetuin‐A (α2HS‐glycoprotein), a liver secretory glycoprotein, is known as a transforming growth factor (TGF)‐β1 signalling inhibitor. Serum…”
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Non-clinical evaluation of a blood-brain barrier-penetrating enzyme for the treatment of mucopolysaccharidosis type I by Kida, Sachiho, Kinoshita, Masafumi, Tanaka, Satowa, Okumura, Miho, Koshimura, Yuri, Morimoto, Hideto

“…Treatment of central nervous system (CNS) disorders in patients with lysosomal storage diseases by intravenous enzyme replacement therapy is still challenging…”
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Non-clinical evaluation of a blood-brain barrier-penetrable N-sulfoglucosamine sulfohydrolase in a mouse model of mucopolysaccharidosis type IIIA by Tanaka, Satowa, Kida, Sachiho, Koshimura, Yuri, Kakimoto, Shinji, Imakiire, Atsushi, Ito, Jun, Miyauchi, Kazuki, Morimoto, Hideto, Minami, Kohtaro, Hirato, Tohru, Sonoda, Hiroyuki

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Reduction of heparan sulfate in the brain by pabinafusp alfa results in prevention of neurodegeneration and neurocognitive impairment in a mouse model of mucopolysaccharidosis type II by Morimoto, Hideto, Kida, Sachiho, Yoden, Eiji, Kinoshita, Masafumi, Tanaka, Noboru, Yamamoto, Ryuji, Koshimura, Yuri, Takagi, Haruna, Takahashi, Kenichi, Hirato, Tohru, Minami, Kohtaro, Sonoda, Hiroyuki

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A novel approach to CNS dysfunction of Pompe disease with a fusion protein consisting of anti-transferrin receptor antibody and GAA enzyme by Tanaka, Satowa, Yoshioka, Aya, Kinoshita, Masafumi, Kida, Sachiho, Imakiire, Atsushi, Takenaka, Shinobu, Morimoto, Hideto, Yamamoto, Ryuji, Minami, Kohtaro, Sonoda, Hiroyuki, Takahashi, Kenichi, Hirato, Tohru

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Serum Mac-2 binding protein levels as a novel diagnostic biomarker for prediction of disease severity and nonalcoholic steatohepatitis by Kamada, Yoshihiro, Fujii, Hideki, Fujii, Hironobu, Sawai, Yoshiyuki, Doi, Yoshinori, Uozumi, Naofumi, Mizutani, Kayo, Akita, Maaya, Sato, Motoya, Kida, Sachiho, Kinoshita, Noriaki, Maruyama, Nobuhiro, Yakushijin, Takayuki, Miyazaki, Masanori, Ezaki, Hisao, Hiramatsu, Naoki, Yoshida, Yuichi, Kiso, Shinichi, Imai, Yasuharu, Kawada, Norifumi, Takehara, Tetsuo, Miyoshi, Eiji

“…Purpose Mac‐2 binding protein (Mac‐2bp) is one of the major fucosylated glycoproteins, which we identified with glycol‐proteomic analyses. We previously…”
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Hepatic aberrant glycosylation by N-acetylglucosaminyltransferase V accelerates HDL assembly by Kamada, Yoshihiro, Kida, Sachiho, Hirano, Ken-Ichi, Yamaguchi, Satoshi, Suzuki, Akira, Hashimoto, Chikako, Kimura, Akihiro, Sato, Motoya, Fujii, Hironobu, Sobajima, Tomoaki, Yamamoto, Akiko, Ebisutani, Yusuke, Takamatsu, Shinji, Shinzaki, Shinichiro, Yoshida, Yuichi, Yamada, Makoto, Nagasaka, Hironori, Takehara, Tetsuo, Miyoshi, Eiji

“…Glycosylation is involved in various pathophysiological conditions. N-Acetylglucosaminyltransferase V (GnT-V), catalyzing β1-6 branching in asparagine-linked…”
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N-Acetylglucosaminyltransferase V exacerbates concanavalin A-induced hepatitis in mice by KAMADA, YOSHIHIRO, SATO, MOTOYA, KIDA, SACHIHO, AKITA, MAAYA, MIZUTANI, KAYO, FUJII, HIRONOBU, SOBAJIMA, TOMOAKI, YOSHIDA, YUICHI, SHINZAKI, SHINICHIRO, TAKAMATSU, SHINJI, TAKEHARA, TETSUO, MIYOSHI, EIJI

“…N-Acetylglucosaminyltransferase V (GnT-V) catalyzes β1-6 branching in asparagine-linked oligosaccharides and is one of the most important glycosyltransferases…”
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