Search Results - "Kicman, Andrew T"

Pharmacokinetics of Mephedrone Enantiomers in Whole Blood after a Controlled Intranasal Administration to Healthy Human Volunteers by Czerwinska, Joanna, Parkin, Mark C, Cilibrizzi, Agostino, George, Claire, Kicman, Andrew T, Dargan, Paul I, Abbate, Vincenzo

“…Mephedrone, which is one of the most popular synthetic cathinones, has one chiral centre and thus exists as two enantiomers: -(+)-mephedrone and…”
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Detection of ketamine and its metabolites in urine by ultra high pressure liquid chromatography–tandem mass spectrometry by Parkin, Mark C., Turfus, Sophie C., Smith, Norman W., Halket, John M., Braithwaite, Robin A., Elliott, Simon P., Osselton, M. David, Cowan, David A., Kicman, Andrew T.

“…Current analytical methods used for screening drugs and their metabolites in biological samples from victims of drug-facilitated sexual assault (DFSA) or other…”
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Use of Human Microsomes and Deuterated Substrates: An Alternative Approach for the Identification of Novel Metabolites of Ketamine by Mass Spectrometry by TURFUS, Sophie C, PARKIN, Mark C, COWAN, David A, HALKET, John M, SMITH, Norman W, BRAITHWAITE, Robin A, ELLIOT, Simon P, STEVENTON, Glyn B, KICMAN, Andrew T

“…In vitro biosynthesis using pooled human liver microsomes was applied to help identify in vivo metabolites of ketamine by liquid chromatography (LC)-tandem…”
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An introduction to mass spectrometry based proteomics—Detection and characterization of gonadotropins and related molecules by Kicman, Andrew T., Parkin, Mark C., Iles, Ray K.

“…This review introduces fundamental aspects of mass spectrometry (MS) based proteomics and illustrates how MS is an effective tool for the analysis of…”
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Detection of mephedrone and its metabolites in fingerprints from a controlled human administration study by liquid chromatography-tandem mass spectrometry and paper spray-mass spectrometry by Czerwinska, Joanna, Jang, Min, Costa, Catia, Parkin, Mark C, George, Claire, Kicman, Andrew T, Bailey, Melanie J, Dargan, Paul I, Abbate, Vincenzo

“…The use of synthetic stimulants, including designer cathinones, remains a significant concern worldwide. Thus, the detection and identification of synthetic…”
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Anabolic steroids in sport: biochemical, clinical and analytical perspectives by Kicman, Andrew T, Gower, D B

“…International Olympic Committee accredited laboratories play a key role in upholding the principle of fair play and innate ability, as desired by the majority…”
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Enhanced Affinity Capture MALDI-TOF MS: Orientation of an Immunoglobulin G Using Recombinant Protein G by Neubert, Hendrik, Jacoby, Eli S, Bansal, Sukhvinder S, Iles, Ray K, Cowan, David A, Kicman, Andrew T

“…Although immobilization of antigen-specific immunoglobulins onto matrix-assisted laser desorption/ionization (MALDI) targets allows the specific detection and…”
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Pharmacokinetics of Mephedrone and Its Metabolites in Whole Blood and Plasma after Controlled Intranasal Administration to Healthy Human Volunteers by Czerwinska, Joanna, Parkin, Mark C, George, Claire, Kicman, Andrew T, Dargan, Paul I, Abbate, Vincenzo

“…Abstract Mephedrone is a popular synthetic cathinone, known for its psychostimulant effects. At present, there is no data available on the pharmacokinetics of…”
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Rapid Analysis of Anabolic Steroid Metabolites in Urine by Combining Field Asymmetric Waveform Ion Mobility Spectrometry with Liquid Chromatography and Mass Spectrometry by Arthur, Kayleigh L, Turner, Matthew A, Brailsford, Alan D, Kicman, Andrew T, Cowan, David A, Reynolds, James C, Creaser, Colin S

“…The combination of field asymmetric waveform ion mobility spectrometry with liquid chromatography–mass spectrometry (LC-FAIMS-MS) has been developed for the…”
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Development of a rapid LC-MS/MS method for direct urinalysis of designer drugs by Bell, Charlotte, George, Claire, Kicman, Andrew T., Traynor, Allan

“…The current immunoassay screening methodologies used to detect sympathomimetic amines within the context of workplace drug testing may fail to detect a number…”
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Excretion of mephedrone and its phase I metabolites in urine after a controlled intranasal administration to healthy human volunteers by Czerwinska, Joanna, Parkin, Mark C., George, Claire, Kicman, Andrew T., Dargan, Paul I., Abbate, Vincenzo

“…Mephedrone is a stimulant drug structurally related to cathinone. At present, there are no data available on the excretion profile of mephedrone and its…”
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Stability of mephedrone and five of its phase I metabolites in human whole blood by Czerwinska, Joanna, Parkin, Mark C., Dargan, Paul I., George, Claire, Kicman, Andrew T., Abbate, Vincenzo

“…Mephedrone is a new psychoactive substance known to be unstable in biological matrices stored at room temperature or refrigerated. While the instability of…”
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Elucidation of the biosynthetic pathways of boldenone in the equine testis by Viljanto, Marjaana J., Kicman, Andrew T., Walker, Christopher J., Parkin, Mark C., Wolff, Kim, Pearce, Clive M., Scarth, James

“…•Boldenone and boldenone are naturally present in the equine testis.•Labelled boldenone was formed from labelled testosterone and androstenedione.•Labelled…”
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The effect of 3,4‐methylenedioxymethamphetamine (MDMA, ?ecstasy?) and its metabolites on neurohypophysial hormone release from the isolated rat hypothalamus by Forsling, Mary L, Fallon, John K, Shah, Darshna, Tilbrook, Gary S, Cowan, David A, Kicman, Andrew T, Hutt, Andrew J

“…Methylenedioxymethamphetamine (MDMA, “ecstasy”), widely used as a recreational drug, can produce hyponatraemia. The possibility that this could result from…”
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Bioformation of boldenone and related precursors/metabolites in equine feces and urine, with relevance to doping control by Viljanto, Marjaana, Kicman, Andrew T., Walker, Christopher J., Wolff, Kim, Muir, Tessa, Hincks, Pamela, Biddle, Simon, Scarth, James

“…Boldenone (1‐dehydrotestosterone) is an exogenous anabolic‐androgenic steroid (AAS) but is also known to be endogenous in the entire male horse and potentially…”
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Pharmacokinetic Properties of γ-Hydroxybutyrate (GHB) in Whole Blood, Serum, and Urine by Brailsford, Alan D., Cowan, David A., Kicman, Andrew T.

“…Over the last 10-15 years, γ-hydroxybutyrate (GHB) and γ-butyrolactone have become increasingly popular "club drugs", but they have also gained attention as…”
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Stereospecific Analysis and Enantiomeric Disposition of 3,4-Methylenedioxymethamphetamine (Ecstasy) in Humans by Fallon, John K, Kicman, Andrew T, Henry, John A, Milligan, Peter J, Cowan, David A, Hutt, Andrew J

“…Little is known concerning the enantioselective disposition of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) in humans. In addition, the potential of…”
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Biochemical and physiological aspects of endogenous androgens by Kicman, Andrew T

“…This review attempts to give a synopsis of the major aspects concerning the biochemistry of endogenous androgens, supplemented with several facets of…”
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Increases in Serum Growth Hormone Concentrations Associated with GHB Administration by Brailsford, Alan D, Bartlett, Christiaan, Kicman, Andrew T, Cowan, David A

“…The administration of gamma-hydroxybutyrate (GHB) has been reported to augment the increase in growth hormone (GH) secretion associated with the onset of…”
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A proposed approach to confirm heroin administration – Regional differences in heroin purity is a major factor by Chen, Wei-Ru, Kong, Po-Hsin, Sauer, Christoph, Chen, Huei-Wen, Chan, Hsiang-Yu, Yang, Da-Peng, Jair, Yung-Cheng, Liu, Hsin-Tung, Lin, Tsang-Yaw, Yen, Muh-Yong, Yen, Yung-Feng, Chang, Sheng-Huang, Li, Lan-Hui, George, Claire, Chang, Ya-Chi, Wu, Yi-Hsin, Hwa, Hsiao-Lin, Chen, Chia-Yang, Chen, Jung-Hsuan, Kicman, Andrew T., Maurer, Hans H., Chen, Pai-Shan

“…In forensic toxicology, a marker of street heroin use is urgent especially in the absence of urinary 6-monoacetylmorphine. ATM4G, the Glucuronide of Acetylated…”
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